DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycbeta100B and gucy1a2

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001120379.1	Gene:	gucy1a2 / 100145454	XenbaseID:	XB-GENE-1011801	Length:	712	Species:	Xenopus tropicalis

Alignment Length:	686	Identity:	213/686 - (31%)
Similarity:	328/686 - (47%)	Gaps:	148/686 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 DDEITYNLIGAAVEILNIPADDILELFGKTFFEFCQDSGYDKILQVLGATPRDFLQNLDALHDHL 108
            |.|....::.....:|.|..:::.|.||:.||..|.:.. :::|:.:|.|..||....|||.:|:
Frog   125 DAEDISGILQCTANMLGIKFEELQERFGEEFFSICFEEN-ERVLRAVGGTLHDFFNGFDALLEHI 188

  Fly   109 GT---LYPGMRAPSFRCTE-KDGELLLHYYSERPGLEHIV----IGIVKAVASKLHGVEVEIDIV 165
            .|   ....:.:|||.|.| .||.|||..:.    |.|||    .|::||...|::.::||::
Frog   189 RTSIGRQVTLESPSFLCKELADGTLLLSCFH----LHHIVGFAMKGLIKAAGKKIYQLKVEVE-- 247

  Fly   166 KRKGEPIDEAEKERAIARENQQLLEDAVATTTTGSATVVLAPSSDAERNNNHNGSNGSNNNGMAN 230

Frog   248 ----------------------------------------------------------------- 247

  Fly   231 NGNTVNVNNNNDGQQIASETDPSIALSTCP--IAQDSFDCDGDKEQKCLRLLKNKSDDIERYDHV 293
                 .|||.|:              ..||  |...:|:|                        :
Frog   248 -----QVNNVNE--------------KPCPDIIRPGNFNC------------------------L 269

  Fly   294 QFLIREINVAAKSQVD-AKKDEVPDDMEFLCEAPLISPATFCKVFPFHLMFDRQMKIVQAGKAVS 357
            .|.|:|.:.|...:.. .:...:|.|:.       ||.:|||:.||||||||..|.|:|.|:.:.
Frog   270 TFKIKECDNANLMKAPLLQSSHIPSDLR-------ISISTFCRAFPFHLMFDPNMLILQLGEGLR 327

  Fly   358 RVIPRVAEENCSLIEVVEAIRPHLQLNFENILSHINTIYVLQTRQGAMSSRHEQRFLRLKGQMMY 422
            ::|.....:.....:..|.:.|.:...||.:|..::|.:|::.:..|.:..::.:.:.:||||:|
Frog   328 KLIKCEVHKTMQFHDSFEIVSPKISCTFEQVLLRLSTPFVIRNKPDAPTFENKDKVMEVKGQMIY 392

  Fly   423 IPETDRILFQCYPSVMNLDDLTKKGLYISDVPLHDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQ 487
            :||:..|||...|.|..||:|..:||::||:|:|||.||::|:.|:.:|:..|.|.::.|...|:
Frog   393 VPESSSILFLGSPRVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLE 457

  Fly   488 QTFRDLESEKQKTDRLLYSVLPKSVANELRHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDG 552
            :|.:.||.||:||..||||:.|..||.:|...:.|..:::|.||::||.||||...||..|
Frog   458 KTHQALEEEKKKTVDLLYSIFPGDVAQQLWEGKSVQARKFDDVTMLFSDIVGFTAVCAQCT---- 518

  Fly   553 AMKIVKMLNELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGLPDHCEDHAKCMARVALDMMDMA 617
            .|:::.|||||||.||.....   |::|||||:||.|...:||......|||.:|.:||.||:::
Frog   519 PMQVISMLNELYTRFDYQCGF---LDIYKVETIGDAYCVAAGLLRQSNSHAKPIALMALKMMELS 580

  Fly   618 KNV-KMGSNPVQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRL 681
            :.| .....|:::.||||||.|:.||:|.|:||||||||.|.|.|:.|:...|.|||||..||:|
Frog   581 EEVLTPDGRPIKMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQL 645

  Fly   682 LCMAINQDDSFHLEYRGPVIMKG---KPTPMDCWFL 714
            |    ..:.:||...|....:..   |..|..|:||
Frog   646 L----KDEANFHFVPRSREELPDNFPKEIPGICYFL 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	40/127 (31%)
		HNOBA	326..516	CDD:285003	72/189 (38%)
		CYCc	496..688	CDD:214485	89/192 (46%)
		Guanylate_cyc	522..714	CDD:278633	83/195 (43%)
gucy1a2	NP_001120379.1	Pap_E4	30..>86	CDD:367150
		HNOB	<132..248	CDD:377902	38/192 (20%)
		HNOBA	296..486	CDD:369471	72/196 (37%)
		Guanylate_cyc	492..679	CDD:306677	85/197 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920