DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and ADGRG7

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_116176.2	Gene:	ADGRG7 / 84873	HGNCID:	19241	Length:	797	Species:	Homo sapiens

Alignment Length:	663	Identity:	165/663 - (24%)
Similarity:	279/663 - (42%)	Gaps:	136/663 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 VKSPPDMISQLSNLLTQTQEKLAAADVFS----ISEIFDSLVKKPERNAAVVGD---LMKICQKV 206
            |.:|.:.||....:||....||.|.::.|    :.:||::     .|||:....   ::.:.|.:
Human   153 VTAPLNNISSEVQILTSDANKLTAENITSATRVVGQIFNT-----SRNASPEAKKVAIVTVSQLL 212

  Fly   207 MSTDNETLRVSADAN--ATNALLSNFEDYLDEL-SPTILKLNTTI-FAN-STEFTFHPLFDMGVI 266
            .::::...||:|.||  |...|:...|.|...| :.::::.|..| .|| |:|....|
Human   213 DASEDAFQRVAATANDDALTTLIEQMETYSLSLGNQSVVEPNIAIQSANFSSENAVGP------- 270

  Fly   267 VLKTSELRVFFVDPEVRNVSGIVNFSGGNMSHFEMLHLS-DNEEDIRAMKNLESAVFIPEKLWTQ 330
                |.:| |.|.....  |.:|  |.....|..:..|: |.:.:::.:.|:       .|.:|
Human   271 ----SNVR-FSVQKGAS--SSLV--SSSTFIHTNVDGLNPDAQTELQVLLNM-------TKNYT- 318

  Fly   331 LKRKGASYLVFKVYTRDSLFVETEEEIKRRPTSNVISI-TIPGLNDTKLPGKLPFFLRNAKANET 394
             |..|     |.||..|.||.......|...:..:||. |.....|......:.|   :.|.|:.
Human   319 -KTCG-----FVVYQNDKLFQSKTFTAKSDFSQKIISSKTDENEQDQSASVDMVF---SPKYNQK 374

  Fly   395 QFE---GGCGYWNY--ETWLSDGISTSGGGSLEASSHPVILCHADHLTQFTFLLGVSKMQAGLDT 454
            :|:   ..|.|||.  :.|.:.|.....|      :...:.|..:|.|.|..|:          |
Human   375 EFQLYSYACVYWNLSAKDWDTYGCQKDKG------TDGFLRCRCNHTTNFAVLM----------T 423

  Fly   455 NEDDH----SLDVITNVGLTLSLLGLLMIFITAAVFKSFRTLASTKILLNLC-AALGLQLLFFLI 514
            .:.|:    |||:::|||..||:.||.:..|...|.:..|..:.|.:|:||| :.|...|||...
Human   424 FKKDYQYPKSLDILSNVGCALSVTGLALTVIFQIVTRKVRKTSVTWVLVNLCISMLIFNLLFVFG 488

  Fly   515 LSQSHLLEQLEQSESE----------------------RCTLVGAVMQYLLLVVFSWMFIIGFLQ 557
            :..|:  :.|:.|:.:                      .||.:.|::.|.|||.|:|..:.....
Human   489 IENSN--KNLQTSDGDINNIDFDNNDIPRTDTINIPNPMCTAIAALLHYFLLVTFTWNALSAAQL 551

  Fly   558 YQRYVRVIGVNHPRHYILMSAVAAWTLPLIP---TLLVVFLEPGSYRPNNS--SMDY--PILCY- 614
            |...:|.: ...|||:||..::..|.:|.|.   |:.|::.:.|    ||.  .:||  ..:|:
Human   552 YYLLIRTM-KPLPRHFILFISLIGWGVPAIVVAITVGVIYSQNG----NNPQWELDYRQEKICWL 611

  Fly   615 ----PSGY---GLSLGVILPIGLITVANAILVGYIS----WSVYTAL--FKRDLIFKQLGLFVLL 666
                |:|.   .|....|:|:.:|.::|.::...||    |.....|  .|:....|::...:.:
Human   612 AIPEPNGVIKSPLLWSFIVPVTIILISNVVMFITISIKVLWKNNQNLTSTKKVSSMKKIVSTLSV 676

  Fly   667 FFLLGITWIFG--LCTYFDFGRI-FAYLFCLTATLQGFVLFLYFI----VFNKENQRAWLGLCCN 724
            ..:.|||||..  :....|..|| |:|:|||..|.||..:|:.:.    ||..|..:. |.|..:
Human   677 AVVFGITWILAYLMLVNDDSIRIVFSYIFCLFNTTQGLQIFILYTVRTKVFQSEASKV-LMLLSS 740

  Fly   725 SSKKRNQQTIQMP 737
            ..::::..::..|
Human   741 IGRRKSLPSVTRP 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	71/268 (26%)
ADGRG7	NP_116176.2	GPS	383..422	CDD:197639	11/44 (25%)
		7tmB2_GPR128	431..737	CDD:320385	86/313 (27%)
		TM helix 1	433..458	CDD:320385	11/24 (46%)
		TM helix 2	468..490	CDD:320385	9/21 (43%)
		TM helix 3	527..554	CDD:320385	9/26 (35%)
		TM helix 4	567..587	CDD:320385	6/19 (32%)
		TM helix 5	621..651	CDD:320385	7/29 (24%)
		TM helix 6	665..692	CDD:320385	6/26 (23%)
		TM helix 7	699..724	CDD:320385	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4561
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41622
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.920