DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15556 and Celsr3

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_112610.1	Gene:	Celsr3 / 83466	RGDID:	621787	Length:	3313	Species:	Rattus norvegicus

Alignment Length:	501	Identity:	125/501 - (24%)
Similarity:	193/501 - (38%)	Gaps:	106/501 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 EMLHLSDNEEDIRAMKNLESAVFIPEKLWTQLKRKGASYLVFKVYTRDSLFVETEEEIKRR---- 360
            |:|..|.|.|:..|     |.|..|..........|.|.::..||......:..:.:.:||
  Rat  2372 EVLPTSSNAENATA-----SGVVSPPAPLEPESEPGISIVILLVYRALGGLLPAQFQAERRGARL 2431

  Fly   361 ---PTSN--VISITI-PGLNDTKLPGKLPFFLRNAKANETQFE-----------GGCGYWN---- 404
               |..|  |:|:.: .|.|          |||.|..:....|           ..|..|:
  Rat  2432 PQNPVMNSPVVSVAVFRGRN----------FLRGALVSPINLEFRLLQTANRSKAICVQWDPPGP 2486

  Fly   405 ---YETWLS---DGISTSGGGSLEASSHPVILCHADHLTQFTFLLGVS---KMQAGLDTNEDDHS 460
               :..|.:   :.:..:|       ||  ..|.......|..|:..|   :::..|:.
  Rat  2487 ADQHGMWTARDCELVHRNG-------SH--ARCRCSRTGTFGVLMDASPRERLEGDLEL------ 2536

  Fly   461 LDVITNVGLTLSLLGLLMIFITAAVFKSFRTLAST--KILLNLCAALGL-QLLFFLILSQSHLLE 522
            |.|.|:|.:..|:..|:   :||||..|.|:|.|.  .|..|:.||||: :|||.|.:.::|  .
  Rat  2537 LAVFTHVVVAASVTALV---LTAAVLLSLRSLKSNVRGIHANVAAALGVAELLFLLGIHRTH--N 2596

  Fly   523 QLEQSESERCTLVGAVMQYLLLVVFSWMFIIGFLQYQRYVRVIGVNH--PRHYILMSAVAAWTLP 585
            ||      .||:|..::.|..|..|:|:.:.|...|:..|....|:.  .|.|..:    .|.:|
  Rat  2597 QL------LCTVVAILLHYFFLSTFAWLLVQGLHLYRMQVEPRNVDRGAMRFYHAL----GWGVP 2651

  Fly   586 LIPTLLVVFLEPGSY-RPNNS--SMDYPILCYPSGYGLSLGVILPIGLITVANAI---LVGYISW 644
            .:...|.|.|:|..| .|:..  |:..|::...:|         ||.|:.|.|.|   |....|.
  Rat  2652 AVLLGLAVGLDPEGYGNPDFCWISIHEPLIWSFAG---------PIVLVIVMNGIMFLLAARTSC 2707

  Fly   645 SVYTALFKRDLIFKQLGLFVLLFFLLGITWIFGLCTYFDFGRIFAYLFCLTATLQGFVLFLYFIV 709
            |......|:..:.:.|....||..|:..:|:|||.........|.||......|||..:.|.|.|
  Rat  2708 STGQREAKKTSVLRTLRSSFLLLLLVSASWLFGLLAVNHSVLAFHYLHAGLCGLQGLAVLLLFCV 2772

  Fly   710 FNKENQRAWLGLCCNSSKKRNQQTIQMPTDSILQGLSHSSTNSTSI 755
            .|.:.:.||...|. ..|...::|...|      |....:.|:|::
  Rat  2773 LNADARAAWTPACL-GKKAAPEETRPAP------GPGSGAYNNTAL 2811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	69/232 (30%)
Celsr3	NP_112610.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	148..187
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..269
		Cadherin_repeat	321..420	CDD:206637
		Cadherin_repeat	428..532	CDD:206637
		Cadherin_repeat	541..638	CDD:206637
		Cadherin_repeat	646..743	CDD:206637
		Cadherin_repeat	751..845	CDD:206637
		Cadherin_repeat	853..948	CDD:206637
		Cadherin_repeat	956..1054	CDD:206637
		Cadherin_repeat	1062..1156	CDD:206637
		Cadherin_repeat	1176..1257	CDD:206637
		EGF_CA	1428..1462	CDD:238011
		EGF_CA	1472..1505	CDD:238011
		LamG	1508..1691	CDD:238058
		EGF_CA	1717..1748	CDD:238011
		LamG	1755..1911	CDD:238058
		EGF_CA	1939..1973	CDD:238011
		EGF_CA	1973..2011	CDD:238011
		Laminin_EGF	<1994..2033	CDD:278482
		EGF_Lam	2030..>2054	CDD:238012
		EGF_Lam	2067..>2105	CDD:238012
		HormR	2117..2181	CDD:214468
		GAIN	2201..2446	CDD:293098	19/78 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2356..2395		9/27 (33%)
		GPS	2474..2527	CDD:197639	10/61 (16%)
		7tm_2	2534..2766	CDD:278432	76/261 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2887..2927
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2977..3004
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3091..3242
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3255..3313
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910