DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15556 and adgrg4a

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	XP_021336868.1	Gene:	adgrg4a / 793963	ZFINID:	ZDB-GENE-121129-2	Length:	1201	Species:	Danio rerio

Alignment Length:	657	Identity:	154/657 - (23%)
Similarity:	254/657 - (38%)	Gaps:	121/657 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 RRCQIRNG---NRVWQSLDHVTC-RSAPELSSSINLLAVKSPP----DMISQLSNLLTQTQEKLA 171
            |.|:: ||   ..:|::.|...| ::..:.....|:.......    |||..|.|  .||....|
Zfish   557 RFCKL-NGATDKAIWEAPDMSKCLKTVSDFGDLENITVTPGNSEYIVDMIEDLLN--EQTGLSNA 618

  Fly   172 AADVF--SISEIFDSLVKKPERNAAVVGDLMKICQKVMSTDNETLRVSADANATNALLSNFEDYL 234
            ..|:.  .:||:.:.....|:.::::...:.:||.   .|.|.|       ..||.:
Zfish   619 QLDIMLEKLSEVTEVGTLTPDLSSSITNIVSEICH---ITTNLT-------QVTNKI-------- 665

  Fly   235 DELSPTILKLNTTIFANSTEFTFHPLFDMGVIVLKTSELRVFFVDPEVRNVSGIVNFSGGNMSHF 299
              ||.|.|..:.|:||........|            .|.:..::|:.....|:.         |
Zfish   666 --LSITDLMGDRTVFAGDAHNMTAP------------SLALQLINPDTSQFHGLT---------F 707

  Fly   300 EMLHLSDN-------EEDIRAMKNLESAVFI--PEKLWTQLKRKGASYLV-FKVYTRDSLFVETE 354
            |:..:.::       :|:.....:..:..||  |..:.......||...| |..|.::.||.:|.
Zfish   708 EVSSVQNDGTPEIFYDENFTENPDTGTVAFISLPPTIENFFPNSGARPRVQFHFYGKEKLFEDTS 772

  Fly   355 EEIKRRPTSNVISITIPGLNDTKLPGKLPFFLRNAKANETQFEGGCGYWNYET------WLSDGI 413
            ..:..  .|.|:|.::.....::|...:...||:.:..|......|.||::..      |...|.
Zfish   773 SNLTL--NSYVVSASVTNATVSELEIPVMVTLRHLQNKEDWDIVKCVYWDFNKNDKKGGWNDRGC 835

  Fly   414 STSGGGSLEASSHPVILCHADHLTQFTFLLGVSKMQAGLDTNEDDHSLDVITNVGLTLSLLGLLM 478
            ......:.:.|      |..||||.|..||.:||...   ..:|:..|.:|:.||..:|.:.|.:
Zfish   836 EIVNSNATQTS------CSCDHLTHFGVLLDISKTPI---NPKDEWVLTIISYVGCGISSIFLGV 891

  Fly   479 IFITAAVFKSFRTLASTKILLNLC-AALGLQLLF-----FLILSQSHLLEQLEQSESERCTLVGA 537
            ..:|...|:..|....:|||:||| |.|||.:||     |...:.:.|           |..|.|
Zfish   892 TLLTYLAFEKLRRDYPSKILINLCMALLGLNMLFLVNSWFASFNSNAL-----------CITVAA 945

  Fly   538 VMQYLLLVVFSWMFIIGFLQYQRYVRVIGVNHPRHYILMSAVAAWTLPLIPTLLVVFLEPGSYRP 602
            ...|..|..|:||.:.....|...|:|.....| .|||......|.:||...:||:.::..||
Zfish   946 FQHYFFLATFTWMGLGAINMYLALVKVFNSYVP-SYILKFCAVGWGIPLSVVILVLAIDFNSY-- 1007

  Fly   603 NNSSMDYPILCYPSGY------------GLSLGVILPIGLITVANAILVGYISWSVYTALFKRDL 655
             .:|:...:|...:.:            .:|..:::.:..|.|...:||......|......|..
Zfish  1008 -GTSLSTDLLQESTAFCWFKNDVTFYVTVVSFAILIMVCNIIVFVVVLVQIHKMRVNKPSSSRKG 1071

  Fly   656 IFKQLGLFVLLFFLLGITWIFGLCTYFDFGRI---FAYLFCLTATLQGFVLFLYFIVFNKENQRA 717
            ....|.:...|.||||:|||.   .:|.:|..   ..|||.:..:||||.:||::.:.....::.
Zfish  1072 FLHDLRVVASLTFLLGLTWIL---VFFGWGPAKTPLMYLFSILNSLQGFFIFLFYCLMKDNVRKQ 1133

  Fly   718 W-LGLCC 723
            | :.|||
Zfish  1134 WRMHLCC 1140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	66/242 (27%)
adgrg4a	XP_021336868.1	LamG	50..210	CDD:328935
		HsdR	<637..>729	CDD:333053	22/132 (17%)
		GPS	815..858	CDD:307782	12/48 (25%)
		7tmB2_GPR112	871..1138	CDD:320663	75/284 (26%)
		TM helix 1	873..898	CDD:320663	7/24 (29%)
		TM helix 2	908..930	CDD:320663	12/21 (57%)
		TM helix 3	941..968	CDD:320663	8/26 (31%)
		TM helix 4	983..999	CDD:320663	3/15 (20%)
		TM helix 5	1028..1051	CDD:320663	3/22 (14%)
		TM helix 6	1073..1098	CDD:320663	10/27 (37%)
		TM helix 7	1102..1127	CDD:320663	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	115	1.000	Domainoid score	I5962
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	108	1.000	Inparanoid score	I4885
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26373
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.060