DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and adgre5b.3

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	XP_005160275.1	Gene:	adgre5b.3 / 792970	ZFINID:	ZDB-GENE-121214-275	Length:	756	Species:	Danio rerio

Alignment Length:	811	Identity:	174/811 - (21%)
Similarity:	292/811 - (36%)	Gaps:	213/811 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 CVDADGQLSHNPYKDCNRGFCKAEDFELEYETDEGKEKRINRVEKTRVGQKANLRDL--CLNERG 110
            ||:.||..    |..|..||                          ::.|....:|:  ||.:..
Zfish    47 CVNTDGSY----YCTCAAGF--------------------------KMSQTGPCKDINECLEDEL 81

  Fly   111 I-PIRRRCQIRNGNRV--------WQS----LDHVTCRSAPELSSSINLLAVKSPPDMISQLSNL 162
            | |.:.||:...|:.|        |::    .|...|.|:|   ..::.....:|...:.:.|..
Zfish    82 ICPAQMRCENTFGSYVCVCPTGHQWKNEAECEDEDECLSSP---CGLHRSCFNTPGSFVCKCSPG 143

  Fly   163 LTQTQEKLAAADVFSISEIFD-------------------------------SLVK------KPE 190
            ..:.:..: .||:...||..|                               ..::      |||
Zfish   144 FRELEGGM-CADINECSESPDVCGTNGDCINNPGGFSCRCHQGFTNYGNNQSKCIEMSCDQFKPE 207

  Fly   191 RNAA--------VVGDLMKICQKVMSTDNETLRVSAD------ANATNALLS--NFED------Y 233
            .:|.        ::..||..|:.:.....|  ..:|:      .|:|:.|||  |..|      :
Zfish   208 PDAGNTPEKLKHLMSLLMNSCKSLNDPHGE--HFTAEKLLENLCNSTDDLLSEGNVADGETLSVF 270

  Fly   234 LDELSPTIL----KLNTTIFANSTEFTFHPLFDMGVIVLKTSELRVFFVDPEVRN---VSGIVNF 291
            ||.:..::.    :|...:....|:.|:             :|:.|      .||   .||.|..
Zfish   271 LDAVENSMRLIGPQLKDPVTKMETQNTY-------------AEVAV------TRNQTPPSGSVTL 316

  Fly   292 SGGNMSHFEMLHLSDNEEDIRAMKNLESAVFIPEKLWTQLKRKGASYLVFKVYTRDSLFVETEEE 356
            |.|:      .|.:.:.|.: ..|:.....|:   .....|...:|..:|....|:...|: |::
Zfish   317 STGS------AHFNTSWETV-VGKSYPGFAFV---ALVSYKDMNSSSDLFNSMAREKSDVK-EKQ 370

  Fly   357 IKRRPTSNVISITI--PGLNDTKLPGKLPFFLRNAKANETQFEGGCGYWNYET--WLSDGISTSG 417
            |..:..|.|::..:  |.......|..|.|.....:|........|.||:...  |...|...:.
Zfish   371 ITYKLNSKVVTAVVSNPDTKHLSKPVTLIFTHEEKRAESEGVAYSCVYWSESERGWSGRGCELAW 435

  Fly   418 GGSLEASSHPVILCHADHLTQFTFLLGVSKMQAGLDTNEDDHSLDVITNVGLTLSLLGLLMIFIT 482
            ..|...:      |...||:.|..|:.:..:       ||...|.|||.|||.|||:.|::..:|
Zfish   436 SNSTHTA------CSCSHLSSFAVLMALYPV-------EDTFELVVITRVGLVLSLICLILCILT 487

  Fly   483 AAVFKSFRTLASTK--ILLNLCAALGLQLLFFLI-LSQSHLLEQLEQSESERCTLVGAVMQYLLL 544
               |:..|::..|:  |.|:|...|.:..|.||. :|.:|        ....|.:|..::.:..|
Zfish   488 ---FRFCRSIQGTRNSIHLHLSVCLFIADLVFLCGISSTH--------NQVACAIVAGLLHFFFL 541

  Fly   545 VVFSWMFIIGFLQYQRYVRVIGVNHPR-HYILMSAVAAWTLPLIPTLLVVFLEPGSYRPNNSSMD 608
            ..|.||.:.|   .|.|..|:.|.|.. .::.|.|| .:.:||:...:.....|..|..:..
Zfish   542 SAFCWMLLEG---VQLYRMVVLVFHTTLKHLYMYAV-GYGVPLVIVSISAIAVPKGYGTDRH--- 599

  Fly   609 YPILCYPS--GYGLSLGVILPIGLITVANAILVGYISW-------SVYTALFKRDLIFKQLGLFV 664
                |:.|  || |.|...:|:.:|.:.|..:.....|       |:...|.|...|...|...|
Zfish   600 ----CWLSLEGY-LILSFFIPVCIIVILNITVFIITVWKLALKFSSLNPDLSKLHKIRSFLATAV 659

  Fly   665 LLFFLLGITWIFGLCTYFDFG-RIFAYLFCLTATLQGFVLFLYFIVFNK----ENQRAWLGLCCN 724
            ....:||.:|:||...:...| .:..|||.:..:|||.::|:...:.:|    |.:..::.:|
Zfish   660 AQLCVLGGSWVFGFFLFQKNGTEVMLYLFIILNSLQGALIFIMHCLLSKQVRVEYRSLFMRMC-- 722

  Fly   725 SSKKRNQQTIQMPTDSILQGLSHSSTNSTSI 755
            |:||:...::.....      ||||.....|
Zfish   723 SNKKKGDYSVSSTEP------SHSSQKPLQI 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	60/235 (26%)
adgre5b.3	XP_005160275.1	EGF_CA	32..>62	CDD:214542	6/18 (33%)
		EGF_CA	72..105	CDD:214542	9/32 (28%)
		EGF_CA	<121..152	CDD:214542	3/34 (9%)
		EGF_CA	154..188	CDD:214542	4/33 (12%)
		GPS	416..460	CDD:197639	11/49 (22%)
		7tm_2	466..699	CDD:278432	71/255 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910