DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and Adgrf4

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001276428.1	Gene:	Adgrf4 / 78249	MGIID:	1925499	Length:	698	Species:	Mus musculus

Alignment Length:	702	Identity:	145/702 - (20%)
Similarity:	240/702 - (34%)	Gaps:	238/702 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 NGNRVWQSLDHVTCRSAPELSSSINLLAVKSPPDMISQLSNLLTQTQEKLAAADVFSISEIFDSL 185
            |.|: ||.... ||.|.     |::.|..:..|  .:.||         ||::.||.:|.|
Mouse    77 NQNK-WQKTIE-TCTSL-----SVDTLFQRIHP--AASLS---------LASSSVFPMSLI---- 119

  Fly   186 VKKPERNAAVV--GDLMKICQKVMSTDN----ETLRVSADANATNA----LLSNFEDYLDE---- 236
                 .|||.|  |::.:..||....|.    :.::.||..:...|    ||.|....|..
Mouse   120 -----GNAAPVHIGNVFQGIQKYCPEDYVCIVDAVKSSAVTSGNIAFIVELLKNISSNLQTSGIH 179

  Fly   237 ------------------LSPTILKLNTTIFANSTEFTFHPLFDMGVIVLKTSELRVFFVDPEVR 283
                              |.||.:. |....||....:     |:      ...:..|....:::
Mouse   180 DNVNWKKMKNYGKVANHILGPTAIS-NWAFIANKNASS-----DL------LESVNSFAKKLQIQ 232

  Fly   284 NVSG------IVNFSGGNMSHFEMLH-LSDNEEDIRAMKNLESAVFIPEKLWTQLKRKGASYLVF 341
            ..|.      .:...|..:||....| ||.:.....|.:::...:.||.:...:|....:..:|.
Mouse   233 GKSESIVDELFIQTKGSRISHSSSEHSLSLSVPRYNATEDVLVVIEIPRQALQELSFNASQAIVV 297

  Fly   342 KVYTRDSLFVETEEEIKRRPTSN--------VISITIP-GLNDTKLPGKLPFFLRNAKANETQ-- 395
            ...|..::..|.     .||.:|        ::|:.:| |||:        ..|...|.|::|
Mouse   298 AFPTLGAILKEV-----HRPNTNLQKPIDDLILSLVLPEGLNE--------IILTFDKINKSQST 349

  Fly   396 ------FEGGCGYWNYE--TWLSDGISTSGGGSLEASSHPVILCHADH---LTQFTFLLGVSKMQ 449
                  ::...|.|:..  |.:||..||             :.|...|   :|.|:.|:....::
Mouse   350 SSQCVSWDPATGQWDESPCTVMSDINST-------------VKCRCRHTKAVTSFSILMSSKPVK 401

  Fly   450 AGLDTNEDDHSLDVITNVGLTLSLLGLLMIFITAAVFKSFRTLASTKI-------LLNLCAALGL 507
            ..:        |:.||.:||::|:..|::..:..|:..|  .:..|:|       ::|:..:|..
Mouse   402 NTI--------LNHITFIGLSISIFSLVLCLVIEAIVWS--RVVVTEISYMRHVCIVNIAVSLLT 456

  Fly   508 QLLFFLILSQSHLLEQLEQSESERCTLVGAVMQYLLLVVFSWMFIIGFLQYQRYVRVIGVNHPRH 572
            ..::|:|.|.   .....|.:.:.|..|..:..:..|.:|.||.....|
Mouse   457 ANVWFIIGSN---FSANVQEDHKWCVAVTFLCHFFFLSLFFWMLFKALL---------------- 502

  Fly   573 YILMSAVAAWTLPLIPTLLVVFLEPGSYRPNNSSMDYPILCYPSGYGLSLGVILPIGLITVANAI 637
                         ::..:||||     .|...|.|      ...|:.:..|..|.|.:|||.
Mouse   503 -------------IVYGILVVF-----RRMMKSRM------MAIGFAIGYGCPLVIAVITVT--- 540

  Fly   638 LV-----GY-------ISWSVYTALF------------------------KRDLI---------- 656
             |     ||       ::|:...|||                        :|.||
Mouse   541 -VTEPGEGYTRKDACWLNWNQTKALFAFAIPALAIVAVNLLVVLAVAINTQRPLIGSSKSQDMAI 604

  Fly   657 -FKQLGLFVLLFFLLGITWIFGLCTYFD-FGRIFAYLFCLTATLQGFVLFLY 706
             |:......:|..|||:||.|||.|..: ...:|..:|.|....|||.:.|:
Mouse   605 VFRISKNVAILTPLLGLTWGFGLTTLLEGVHLVFHIIFALLNAFQGFFILLF 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	58/276 (21%)
Adgrf4	NP_001276428.1	GPS	351..394	CDD:366827	11/55 (20%)
		7tm_GPCRs	402..669	CDD:391938	66/312 (21%)
		TM helix 1	405..429	CDD:341315	7/23 (30%)
		TM helix 2	444..465	CDD:341315	4/20 (20%)
		TM helix 3	479..501	CDD:341315	5/21 (24%)
		TM helix 4	522..538	CDD:341315	4/15 (27%)
		TM helix 5	560..583	CDD:341315	3/22 (14%)
		TM helix 6	606..631	CDD:341315	11/24 (46%)
		TM helix 7	636..661	CDD:341315	7/21 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900