DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and Adgra3

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_598672.1	Gene:	Adgra3 / 70693	MGIID:	1917943	Length:	1310	Species:	Mus musculus

Alignment Length:	785	Identity:	157/785 - (20%)
Similarity:	285/785 - (36%)	Gaps:	233/785 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 RRCQIRNGNRVWQSLDHVTCRSAPELSSSINLLAVKSPPDMISQLSNLLTQTQEKLA----AA-- 173
            |||. |.|  .|...|:..|:.|.:::..:.:.     ..|...|:|.:...::.||    ||
Mouse   387 RRCD-RGG--FWADDDYSRCQYANDVTRVLYMF-----NQMPLNLTNAVATARQLLAYTVEAANF 443

  Fly   174 ----DVFSISEIFDSLVK-KPERNAAVVGDLM-KICQKVMSTDNETLRVS-ADANATNALLSNFE 231
                ||..::|:.:...: ..|..:..:||:| .:...:|..|...|.:: .:|.|.:.::
Mouse   444 SDKMDVIFVAEMIEKFGRFTREEKSKELGDVMVDVASNIMLADERVLWLAQREAKACSRIV---- 504

  Fly   232 DYLDELSPTILKLNTTIFANSTEFTFHPLFDMGVIVLKTSELRVFFVDPEVRNVSGIVNFSGGNM 296
            ..|..::...|.....:::     |:.|...:...|:|.:                  .|:|...
Mouse   505 QCLQRIATHRLASGAHVYS-----TYSPNIALEAYVIKAA------------------GFTGMTC 546

  Fly   297 SHFEMLHLSDN---------------EEDIR------------AMKN--LESAVFIPEKLWT--- 329
            |.|:.:..||.               ::.:.            |:||  :|:::.:|..|.:
Mouse   547 SVFQKVAASDRAGLSDYGRRDPDGNLDKQLSFKCNVSSTFSSLALKNTIMEASIQLPSSLLSPKH 611

  Fly   330 QLKRKGASYLVFKV----YTRDSLFVET------EEEIKRRPTSNVISIT-IPGLN-DT-KLPGK 381
            :.:.:.|...::|:    :....||..|      .::.|||.....:.:| |.|.. || .:|..
Mouse   612 KREARAADDALYKLQLIAFRNGKLFPATGNSTKLADDGKRRTVVTPVILTKIDGATVDTHHIPVN 676

  Fly   382 LPF--FLRNAKANETQFEGGCGYWNYET------WLSDG---------ISTSGGGSLEASSHPVI 429
            :..  ....|.|...|       |:::.      |.|||         |:|...|||  .::.|:
Mouse   677 VTLRRIAHGADAVAAQ-------WDFDLLNGQGGWKSDGCCILYSDENITTIQCGSL--GNYAVL 732

  Fly   430 LCHADHLTQFTFLLGVSKMQAGLDTNEDDHSL--DVITNVGLTLSLLGLLMIFITAAVFKSF--R 490
            :    .||             |.:......||  .|:....:|| ||.||.:.|:.....|.  .
Mouse   733 M----DLT-------------GTELYTPAASLLHPVVYTTAITL-LLCLLAVIISYMYHHSLIRI 779

  Fly   491 TLASTKILLNLCAALGLQLLFFLILSQSHLLEQLEQSESER-CTLVGAVMQYLLLVVFSWMFIIG 554
            :|.|..:|:|||        |.::|:....:..:.|:.:.. |..||.::.|..|....|:.:..
Mouse   780 SLKSWHMLVNLC--------FHILLTCVVFVGGITQTRNASVCQAVGIILHYSTLATVLWVGVTA 836

  Fly   555 FLQYQRYV----RVIGVNHP--------RHYILMSAVAAWTLPLIPTLLVVFLEPGSY--RPNNS 605
            ...|::..    |....:.|        |.|::...:     |:|...:.......:|  ||
Mouse   837 RNIYKQVTKKAKRCQDPDEPPAPPRPMLRFYLIGGGI-----PIIVCGITAAANIKNYGSRP--- 893

  Fly   606 SMDYPILCYPSGYGLSLGVILPIGLITVANAILV------------------------------- 639
            |..|..:.:....|...|   |...||..|.:..
Mouse   894 SAPYCWMAWEPSLGAFYG---PASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANE 955

  Fly   640 -GYISWS-------VYTALFKRDLIFKQ--LG--LFVLLFFLLGITWIFG---LCTYFDFGRIFA 689
             |.|:..       :.|:..:.:..|:.  ||  |.:||:.:|   |:||   :..|:....:|:
Mouse   956 NGEINHQDSMSLSLISTSTLENEHSFQSQLLGASLTLLLYVIL---WMFGAMAVSLYYPLDLVFS 1017

  Fly   690 YLF---CLTATLQGFVLFLYFIVFNKENQR-AWLGLCC-NSSKKRNQQTIQMPTDSILQGLSHSS 749
            :.|   ||  :...|::..:.|  |:|:.| ||:.:|| ..|....|..:|.|..|...|.:...
Mouse  1018 FFFGATCL--SFSAFMMVHHCI--NREDVRLAWIMMCCPGRSSYSVQVNVQPPNSSATNGEAPKC 1078

  Fly   750 TNSTS 754
            |||::
Mouse  1079 TNSSA 1083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	54/287 (19%)
Adgra3	NP_598672.1	LRR 1	71..92
		leucine-rich repeat	72..95	CDD:275378
		LRR_RI	<73..155	CDD:238064
		LRR_8	74..130	CDD:290566
		LRR 2	95..116
		leucine-rich repeat	96..119	CDD:275378
		LRR_8	118..171	CDD:290566
		LRR_4	119..158	CDD:289563
		LRR 3	119..140
		leucine-rich repeat	120..143	CDD:275378
		LRR 4	143..164
		leucine-rich repeat	144..167	CDD:275378
		LRRCT	178..>212	CDD:214507
		IG_like	238..330	CDD:214653
		Ig	242..326	CDD:299845
		HRM	<352..405	CDD:280888	8/20 (40%)
		GPS	688..732	CDD:280071	12/52 (23%)
		7tm_4	751..>934	CDD:304433	42/202 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1065..1084		6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1187..1208
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1221..1264
		PDZ-binding. /evidence=ECO:0000255	1308..1310
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910