Protein Alignment Ktch and adgrl2a

DIOPT Version :10

• Sequence 1: NP_651845.2
• Gene: Ktch / 43681
• FlyBaseID: FBgn0039821
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: XP_073772399.1
• Gene: adgrl2a / 57987
• ZFINID: ZDB-GENE-000607-49
• Length: 1500
• Species: Danio rerio
• Alignment Length: 764
• Identity: 176/764 - (23%)
• Similarity: 279/764 - (36%)
• Gaps: 204/764 - (26%)

  Fly    94 RVGQKANLRDLC--LNERGIPIRRRCQIRNGNR------------VWQSLDHVTCRSAPELSSS- 143
            |..:...|||:.  ..:||:.:.|.|.  .|.|            .|..       ..|:||:.
Zfish   479 RFCESVELRDILWPQTQRGMLVERPCP--KGTRGTASYLCVLSTGTWNP-------KGPDLSNCT 534

  Fly   144 ---INLLA--VKSPPDMISQLSNLLTQTQEKLAAADVFSISEIFDSLVK---------KPERNAA 194
               :|.:|  ::|..:..:..:.|...|:..:.|.|:.|...:.:.||.         :|....:
Zfish   535 SHWVNQVAQKIRSGENAANLANELAKHTKGAIFAGDISSTMRLMEQLVDILDAQLQELRPSEKDS 599

  Fly   195 VVGDLMKI------CQKVM-----STDN----ETLRVSADANAT------NALLSNFED----YL 234
            ......|:      |:..|     :.||    |.|:...|.|.|      ..||...|:    ..
Zfish   600 TGRSFNKLQKRERTCRAYMKAIVDTVDNLLRPEALKSWRDMNTTEQTHAATMLLDTLEEGAFVLA 664

  Fly   235 DEL-SPTILKLNTTIFANSTEFTFHPLFDMGVIVLKTSELRVFFVDPEVRNVSGIVNFSG-GNMS 297
            |.| .|.|:|:..:...            :.|.||.|......|..|:          || |.:|
Zfish   665 DNLMEPAIVKVPASNII------------LDVYVLSTDGQVQDFRFPQ----------SGRGGIS 707

  Fly   298 HFEMLHLSDNEEDIRAMKNLESAVFIPEKLWTQLKRKGASYLVFKVYTRDSLFVETE-------E 355
                :.||.|...:.:                   |.|.:.|||.:|.....|:.||       :
Zfish   708 ----IQLSSNTVKLNS-------------------RNGVAKLVFALYKNLGQFLSTENATMKLGQ 749

  Fly   356 EIKRR-----PTSNVISITIPGLNDTKLPGKLPFFLRNAKANETQFEGGCGYWNY-ETWLSDGIS 414
            |:..|     ..|:||:.:|...:......:...|.......:..:...|.:||| |..:....|
Zfish   750 EVNGRNLSVAVNSDVIAASINKESSRVFISEPVIFTLEHIDMQHYYNSNCSFWNYSERTMMGYWS 814

  Fly   415 TSGGGSLEAS-SHPVILCHADHLTQFTF------LLGVSKMQAGLDTNEDDHSLDVITNVGLTLS 472
            |.|...:.|: ||..  |...|||.|..      |||..|:|..|        |.||:.||:.:|
Zfish   815 TQGCKLIHANKSHTT--CSCSHLTNFAVLMAHRELLGADKVQELL--------LSVISRVGIVVS 869

  Fly   473 LLGLLMIFITAAVFKSFRTLASTKILLNLCAALGLQLLFFLILSQSHLLEQLEQSESE-RCTLVG 536
            |:.|.|...|...|:..::..:| |..|||..|.:..|.|||        .::.:|.: .|:::.
Zfish   870 LICLAMSIFTFCFFRGLQSDRNT-IHKNLCINLFIAELIFLI--------GIDMTEPKLACSIIA 925

  Fly   537 AVMQYLLLVVFSWMFIIGFLQYQRYVRVIGVNHPRH-YILMSAVAAWTLPLIPTLLVVFLEPGSY 600
            .::.|..|..|:||.:.|...|...|.|....:.|. |..|   |.:.||.:...:...::..||
Zfish   926 GILHYFFLASFAWMCLEGVQLYLMLVEVFESEYSRRKYFYM---AGYLLPAVVVGVSAAVDFRSY 987

  Fly   601 RPNNS---SMDYPILCYPSGYGLSLGVILPIGLITVANAI--LVGYISWSVYTALFKRDL----- 655
            ....:   .||...:         ...|.|:..|.:.|.|  |:.......::...|.|.
Zfish   988 GTKKACWLRMDNHFI---------WSFIGPVTFIIMLNLIFLLITMYKMMKHSTSLKPDSSRLEH 1043

  Fly   656 --------IFKQ--LGLFVLLFFLLGITWIFGLCTYFDFGRIFAYLFCLTATLQGFVLFLYFIVF 710
                    ..|.  :|.|.|| .|||:||.|||....:...:.||||.:..|.||..:|.:..:.
Zfish  1044 INYEDNKPFIKSWVMGGFALL-CLLGLTWSFGLFFISESSVVLAYLFTIFNTFQGMFIFTFHCLL 1107

  Fly   711 NKENQRAWL-----GLCCNSSKKRNQQTIQMPTDSILQGLSHSSTNSTS 754
            .|:.:|.:.     ..||:          ::.|:|     |||||.:::
Zfish  1108 QKKVRREYSKCLRHTYCCS----------RITTES-----SHSSTKTST 1141

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ktch	NP_651845.2	7tmB2_Adhesion	458..718	CDD:320168	73/281 (26%)
		TM helix 1	460..485	CDD:320168	10/24 (42%)
		TM helix 2	495..517	CDD:320168	10/21 (48%)
		TM helix 3	533..559	CDD:320168	6/25 (24%)
		TM helix 4	574..594	CDD:320168	4/19 (21%)
		TM helix 5	617..646	CDD:320168	6/30 (20%)
		TM helix 6	656..682	CDD:320168	13/27 (48%)
		TM helix 7	686..711	CDD:320168	8/24 (33%)
adgrl2a	XP_073772399.1	None