DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and adgrl2a

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	XP_021335387.1	Gene:	adgrl2a / 57987	ZFINID:	ZDB-GENE-000607-49	Length:	1520	Species:	Danio rerio

Alignment Length:	799	Identity:	180/799 - (22%)
Similarity:	283/799 - (35%)	Gaps:	259/799 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 RVGQKANLRDLC--LNERGIPIRRRCQIRNGNR------------VWQSLDHVTCRSAPELSSS- 143
            |..:...|||:.  ..:||:.:.|.|.  .|.|            .|..       ..|:||:.
Zfish   484 RFCESVELRDILWPQTQRGMLVERPCP--KGTRGTASYLCVLSTGTWNP-------KGPDLSNCT 539

  Fly   144 ---INLLA--VKSPPDMISQLSNLLTQTQEKLAAADVFSISEIFDSLVK---------KPERNAA 194
               :|.:|  ::|..:..:..:.|...|:..:.|.|:.|...:.:.||.         :|....:
Zfish   540 SHWVNQVAQKIRSGENAANLANELAKHTKGAIFAGDISSTMRLMEQLVDILDAQLQELRPSEKDS 604

  Fly   195 VVGDLMKI------CQKVM-----STDN----ETLRVSADANAT------NALLSNFED----YL 234
            ......|:      |:..|     :.||    |.|:...|.|.|      ..||...|:    ..
Zfish   605 TGRSFNKLQKRERTCRAYMKAIVDTVDNLLRPEALKSWRDMNTTEQTHAATMLLDTLEEGAFVLA 669

  Fly   235 DEL-SPTILKLNTTIFANSTEFTFHPLFDMGVIVLKTSELRVFFVDPEVRNVSGIVNFSG-GNMS 297
            |.| .|.|:|:..:...            :.|.||.|......|..|:          || |.:|
Zfish   670 DNLMEPAIVKVPASNII------------LDVYVLSTDGQVQDFRFPQ----------SGRGGIS 712

  Fly   298 HFEMLHLSDNEEDIRAMKNLESAVFIPEKLWTQLKRKGASYLVFKVYTRDSLFVETE-------E 355
                :.||.|...:.:                   |.|.:.|||.:|.....|:.||       :
Zfish   713 ----IQLSSNTVKLNS-------------------RNGVAKLVFALYKNLGQFLSTENATMKLGQ 754

  Fly   356 EIKRR-----PTSNVISITIPGLNDTKLPGKLPFFLRNAKANETQFEGGCGYWNY-ETWLSDGIS 414
            |:..|     ..|:||:.:|...:......:...|.......:..:...|.:||| |..:....|
Zfish   755 EVNGRNLSVAVNSDVIAASINKESSRVFISEPVIFTLEHIDMQHYYNSNCSFWNYSERTMMGYWS 819

  Fly   415 TSGGGSLEAS-SHPVILCHADHLTQFTF------LLGVSKMQAGLDTNEDDHSLDVITNVGLTLS 472
            |.|...:.|: ||..  |...|||.|..      |||..|:|..|        |.||:.||:.:|
Zfish   820 TQGCKLIHANKSHTT--CSCSHLTNFAVLMAHRELLGADKVQELL--------LSVISRVGIVVS 874

  Fly   473 LLGLLMIFITAAVFKSFRTLASTKILLNLCAALGLQLLFFLILSQSHLLEQLEQSESE-RCTLVG 536
            |:.|.|...|...|:..::..:| |..|||..|.:..|.|||        .::.:|.: .|:::.
Zfish   875 LICLAMSIFTFCFFRGLQSDRNT-IHKNLCINLFIAELIFLI--------GIDMTEPKLACSIIA 930

  Fly   537 AVMQYLLLVVFSWMFIIGFLQYQRYVRVIGVNHPRH-------YILMSAV--------------- 579
            .::.|..|..|:||.:.|...|...|.|....:.|.       |:|.:.|
Zfish   931 GILHYFFLASFAWMCLEGVQLYLMLVEVFESEYSRRKYFYMAGYLLPAVVVGVSAAVDFRSYGTK 995

  Fly   580 -AAW-------------TLPLIPTLLVVFL---------EPGSYRPNNSSMD----YPILCYPSG 617
             |.|             .:..|..|.::||         ...|.:|::|.::    |.: |  .|
Zfish   996 KACWLRMDNHFIWSFIGPVTFIIMLNLIFLLITMYKMMKHSTSLKPDSSRLEHINNYRV-C--DG 1057

  Fly   618 YGLSLGVILPIGLITVANAILVGY-------ISWSVYTALFKRDLIFKQLGLFVLLFFLLGITWI 675
            |               .|:.|.||       .||              .:|.|.|| .|||:||.
Zfish  1058 Y---------------YNSDLPGYEDNKPFIKSW--------------VMGGFALL-CLLGLTWS 1092

  Fly   676 FGLCTYFDFGRIFAYLFCLTATLQGFVLFLYFIVFNKENQRAWL-----GLCCNSSKKRNQQTIQ 735
            |||....:...:.||||.:..|.||..:|.:..:..|:.:|.:.     ..||:          :
Zfish  1093 FGLFFISESSVVLAYLFTIFNTFQGMFIFTFHCLLQKKVRREYSKCLRHTYCCS----------R 1147

  Fly   736 MPTDSILQGLSHSSTNSTS 754
            :.|:|     |||||.:::
Zfish  1148 ITTES-----SHSSTKTST 1161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	65/278 (23%)
adgrl2a	XP_021335387.1	Gal_Lectin	61..141	CDD:307994
		OLF	155..411	CDD:321983
		HormR	482..545	CDD:214468	14/69 (20%)
		GAIN	555..776	CDD:318649	54/265 (20%)
		GPS	800..851	CDD:197639	16/52 (31%)
		7tm_GPCRs	860..1141	CDD:333717	78/330 (24%)
		TM helix 1	863..887	CDD:320095	10/23 (43%)
		TM helix 2	896..917	CDD:320095	10/29 (34%)
		TM helix 3	927..949	CDD:320095	5/21 (24%)
		TM helix 4	968..984	CDD:320095	3/15 (20%)
		TM helix 5	1003..1026	CDD:320095	3/22 (14%)
		TM helix 6	1074..1099	CDD:320095	14/39 (36%)
		TM helix 7	1103..1128	CDD:320095	8/24 (33%)
		Latrophilin	1140..1520	CDD:308136	9/37 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810