DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ktch and ADGRB2

DIOPT Version :10

Sequence 1:NP_651845.2 Gene:Ktch / 43681 FlyBaseID:FBgn0039821 Length:755 Species:Drosophila melanogaster
Sequence 2:NP_001351786.1 Gene:ADGRB2 / 576 HGNCID:944 Length:1585 Species:Homo sapiens


Alignment Length:745 Identity:156/745 - (20%)
Similarity:252/745 - (33%) Gaps:236/745 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   110 GIPIRRRCQIRNGNRVWQSL-DHVTCRSAPELSSSINLLAVKSPPDMISQLSNLLTQ----TQEK 169
            |:|...||.......::.|| :|        |:....:||.:....::..|..||.:    :.:.
Human   580 GLPSFARCISHEYRYLYLSLREH--------LAKGQRMLAGEGMSQVVRSLQELLARRTYYSGDL 636

  Fly   170 LAAADVF-SISEIFDSLVKKPERNAAVVGDLMKICQKV-MSTDNETLRVSADANATNA----LLS 228
            |.:.|:. ::::.|......|..:     |:.:..|.| ...|.|......||...:.    ||.
Human   637 LFSVDILRNVTDTFKRATYVPSAD-----DVQRFFQVVSFMVDAENKEKWDDAQQVSPGSVHLLR 696

  Fly   229 NFEDYL----DEL----SPTILKLNTTI-------FANSTEFTFHPLFDMGV-IVLKTSELRVFF 277
            ..||::    |.|    |..|:..|..|       .|.|::.||......|: ..::.||.|: |
Human   697 VVEDFIHLVGDALKAFQSSLIVTDNLVISIQREPVSAVSSDITFPMRGRRGMKDWVRHSEDRL-F 760

  Fly   278 VDPEVRNVS--------------------GIVNFSGGNMSHFEMLHLSDNEEDIRAMKNLESAVF 322
            :..||.::|                    |.|. .|...||..:|....:|              
Human   761 LPKEVLSLSSPGKPATSGAAGSPGRGRGPGTVP-PGPGHSHQRLLPADPDE-------------- 810

  Fly   323 IPEKLWTQLKRKGASYLVF--KVYTRDSLFVETEEEIKRRP----TSNVISITI-PGLNDTKLPG 380
                         :||.|.  .:|....|.:...     ||    ||.|:::|: |   .|:.|.
Human   811 -------------SSYFVIGAVLYRTLGLILPPP-----RPPLAVTSRVMTVTVRP---PTQPPA 854

  Fly   381 ------KLPFFLRNAKANETQFEGGCGYWNYE-------TWLSDGISTSGGGSLEA-SSHPVILC 431
                  :|.:.:....      :..|..|:|.       .|.::...|     ||. ::|  ..|
Human   855 EPLITVELSYIINGTT------DPHCASWDYSRADASSGDWDTENCQT-----LETQAAH--TRC 906

  Fly   432 HADHLTQFTFLLGVSKMQAGLDTNEDDHSLDVITN------VGLTLSLLGLLMIFITAAVFKSFR 490
            ...||:.|..|....|          |.:|::..:      :|..:|.:.||.:....|.|..|.
Human   907 QCQHLSTFAVLAQPPK----------DLTLELAGSPSVPLVIGCAVSCMALLTLLAIYAAFWRFI 961

  Fly   491 TLASTKILLNLCAALGLQLLFFLILSQSHLLEQLEQSESERCTLVGAVMQYLLLVVFSWMFIIGF 555
            ....:.||||.|.:: |.....:::.||.:|.:      ..||:..|.:.:..|..|.|:.... 
Human   962 KSERSIILLNFCLSI-LASNILILVGQSRVLSK------GVCTMTAAFLHFFFLSSFCWVLTEA- 1018

  Fly   556 LQYQRYVRVIGVNHPRHYILMSAVAAWTLPLIPTLLVVFLEPGSYRPNNSSMDYPILCYPSGYG- 619
              :|.|:.|||....|..........|.||    .|||.:..|..|             ..||| 
Human  1019 --WQSYLAVIGRMRTRLVRKRFLCLGWGLP----ALVVAVSVGFTR-------------TKGYGT 1064

  Fly   620 -----LSL-GVIL-----PIGLITVANAILVGYISWSVYTALFKRDLI----------------- 656
                 ||| |.:|     |..:|.:.| :|:|.|   |:..|..||.|                 
Human  1065 SSYCWLSLEGGLLYAFVGPAAVIVLVN-MLIGII---VFNKLMARDGISDKSKKQRAGSERCPWA 1125

  Fly   657 -------------------------FKQLGLFVLLFFLLGITWIFGLCTYFDFGRI-FAYLFCLT 695
                                     ...|....::..||.:||:..:....|...: |..||.:.
Human  1126 SLLLPCSACGAVPSPLLSSASARNAMASLWSSCVVLPLLALTWMSAVLAMTDRRSVLFQALFAVF 1190

  Fly   696 ATLQGFVLFLYFIVFNKENQ---RAWLGLC 722
            .:.||||:........:|.|   :..:|:|
Human  1191 NSAQGFVITAVHCFLRREVQDVVKCQMGVC 1220

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KtchNP_651845.2 7tmB2_Adhesion 458..718 CDD:320168 72/323 (22%)
TM helix 1 460..485 CDD:320168 5/30 (17%)
TM helix 2 495..517 CDD:320168 6/21 (29%)
TM helix 3 533..559 CDD:320168 5/25 (20%)
TM helix 4 574..594 CDD:320168 5/19 (26%)
TM helix 5 617..646 CDD:320168 14/40 (35%)
TM helix 6 656..682 CDD:320168 6/67 (9%)
TM helix 7 686..711 CDD:320168 7/25 (28%)
ADGRB2NP_001351786.1 AGRB_N 38..230 CDD:465991
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 229..271
TSP1 314..362 CDD:214559
TSP1 367..417 CDD:214559
TSP1 422..472 CDD:214559
TSP1 478..528 CDD:214559
HormR 531..595 CDD:214468 4/14 (29%)
GAIN 614..>769 CDD:465137 35/160 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 767..806 7/39 (18%)
GPS 870..923 CDD:197639 14/75 (19%)
GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098 874..924 14/66 (21%)
7tmB2_BAI2 929..1219 CDD:320654 70/320 (22%)
TM helix 1 931..956 CDD:320654 4/24 (17%)
TM helix 2 966..988 CDD:320654 6/22 (27%)
TM helix 3 997..1025 CDD:320654 7/30 (23%)
TM helix 4 1035..1055 CDD:320654 6/23 (26%)
TM helix 5 1073..1102 CDD:320654 9/32 (28%)
TM helix 6 1149..1176 CDD:320654 5/26 (19%)
TM helix 7 1181..1206 CDD:320654 7/24 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1359..1385
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1423..1454
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1498..1585
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.