DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15556 and adgrd2

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	XP_021334184.1	Gene:	adgrd2 / 571770	ZFINID:	ZDB-GENE-081104-190	Length:	1145	Species:	Danio rerio

Alignment Length:	700	Identity:	156/700 - (22%)
Similarity:	278/700 - (39%)	Gaps:	168/700 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 RRRCQIRNGNRVWQSLDHVTCRSAPELSSSI--------------NLLAVKSPPDMISQLSNLLT 164
            :..|::..|   |.:       :.|:.||::              :.|.:|...:.:....:...
Zfish   421 QEECEVLKG---WSA-------ARPQYSSAVCTHTFPFICRISTEHYLKMKELRESLRSNPSPFM 475

  Fly   165 QT--QEKLAAADVFSISEIFDSLVKKPERNAAVVGDLMKICQKVMSTDNETLR----VS------ 217
            |:  |..:.|.||  :|:..|      :::.|.|..|:.:.::||.|:.:.|.    ||
Zfish   476 QSLMQYGMTAEDV--LSDAVD------DQSWASVSRLLNVSEQVMLTEQKPLEDRDMVSLVHVLS 532

  Fly   218 -------------ADANA--------TNALLSNFEDY----------------LDELSPTILKLN 245
                         |||..        .::|||. :|:                :..:....:.||
Zfish   533 RAADLPITANHSRADAETLGQSFITIADSLLSQ-DDHEKWQSIKEVVKGPMAVIQTVERMGINLN 596

  Fly   246 TTIFANSTEFTFHPLFDMGVIVLKTSELRVFFVDPEVRNVSGIVNFSGGNMSHF-----EMLHLS 305
            :.:..::.....|    ...|.|:..: ::...||   :||......|||....     .|..|.
Zfish   597 SLLTDDTDSVQIH----SHNIKLQVQQ-KLLSEDP---HVSAFCGSDGGNRDCISVPAKNMKELR 653

  Fly   306 DNEEDIRAMKNLESAVFIPEKLWTQ----LKRKGASYLVFKVYTRDS-LFVETEEEIKRRPTSNV 365
            :|  |.|.:..|.:        |..    |..|..:..:|.:.|..| .||.|.      ..|:|
Zfish   654 NN--DFRKVTVLNT--------WFSSVKCLSEKEENISLFPIVTDGSQRFVGTV------LGSSV 702

  Fly   366 ISITIPGLNDTKLPGKLPFFLRNAKAN-ETQFEGGCGYWNYETWLSDGISTSGGGSLE-----AS 424
            ||.|:.. ::..:...:.|.|::...| ..:|...|.:|:::. :|||    ||.|.:     ::
Zfish   703 ISSTVLA-DEQPVSVAIHFTLQHRLQNTSVKFIPVCAFWDFDL-MSDG----GGWSTKGCVVIST 761

  Fly   425 SHPVILCHADHLTQFTFLLGVSKMQAGLDTNEDDHSLDVITNVGLTLSLLGLL---MIFITAAVF 486
            .:....|:.:|.|.|..||.:.::|...   ..|..|.:::.:|..:||..|:   ::|:...|.
Zfish   762 QNNSTSCYCNHTTNFALLLQIYEVQRDA---VHDAGLQILSLIGSAVSLCALIFTFILFVAVGVP 823

  Fly   487 KSFRTLASTKILLNLCAALGLQLLFFLILSQSHLLEQLEQSESERCTLVGAVMQYLLLVVFSWMF 551
            ||.|    |.:..||.||| :...|.||||      .......|.|.||.|::....|..|.||.
Zfish   824 KSDR----TTVHKNLMAAL-IVAQFLLILS------DWAAGSQEACWLVTALLHLFFLSSFCWML 877

  Fly   552 IIGFLQYQRYVRVIGVNHPRHYILMSAVAAWTLPLIPTLLVVFLEPGSYRPN-------NSSMDY 609
            :.|.|.:.:.|.| .::..|. :.|..|..|.||::...:.:......|:..       .||:.:
Zfish   878 VEGLLLWSKVVSV-NISEDRR-MKMYYVLGWGLPVVIVAVTLVATLDQYKAQQHCWLNLQSSVIW 940

  Fly   610 ----PILCYPSGYGLSLG--VILPIGLITVANA-ILVGYISWSVYTALFKRDLIFKQLGLFVLLF 667
                |:|     :.|::.  |:..:.|:||::| .....::.|..:.|...||.:......::|.
Zfish   941 AFAGPVL-----FVLAVNAVVLFRVVLVTVSSARRRAKMLTPSSDSKLHTLDLTWAATRPVLILL 1000

  Fly   668 FLLGITWIFGLCTYFDFGRIFAYLFCLTATLQGFVLFLYFIVFNKENQRA 717
            .:||:||:.|:..:  ...:.||||......||..:||.:.|:|.|.:.|
Zfish  1001 PVLGLTWLCGVLVH--LSDVMAYLFITLNAFQGLYIFLVYAVYNSEVRNA 1048

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	61/235 (26%)
adgrd2	XP_021334184.1	LamG	204..402	CDD:328935
		GPS	735..779	CDD:307782	12/48 (25%)
		7tmB2_GPR144	792..1054	CDD:320383	73/276 (26%)
		TM helix 1	794..819	CDD:320383	6/24 (25%)
		TM helix 2	828..850	CDD:320383	11/28 (39%)
		TM helix 3	859..886	CDD:320383	9/26 (35%)
		TM helix 4	898..918	CDD:320383	5/19 (26%)
		TM helix 5	935..964	CDD:320383	7/33 (21%)
		TM helix 6	988..1015	CDD:320383	7/28 (25%)
		TM helix 7	1017..1042	CDD:320383	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910