DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and adgrg6

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001356058.1	Gene:	adgrg6 / 561970	ZFINID:	ZDB-GENE-041014-357	Length:	1208	Species:	Danio rerio

Alignment Length:	754	Identity:	179/754 - (23%)
Similarity:	290/754 - (38%)	Gaps:	168/754 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 CKAEDFELEYETDEGKEKRINRVEKTRVGQKANLRDLCLNERGIPIRRRCQIRNGN--RVWQSLD 130
            |:|::|.:.|...|.:......|.             |...:.....|.|.|...|  ..|...|
Zfish   476 CQADEFPVHYRWPESRPTVTQYVP-------------CFPYKDRNASRTCMINRDNYTSFWALPD 527

  Fly   131 HVTCRSAPELSSSINLLAVKSPPDMISQLSNL---------LTQTQEKLAAADVFSISEIFDSLV 186
            ...|.:...::     ::.::..|:..||:::         |||...|:  .::.:|::|
Zfish   528 RGNCTNITSIT-----VSQENAMDVAVQLADISNNGLSKEELTQVVTKV--MELVNIAKI----- 580

  Fly   187 KKPERNAAVVGDLMKICQKVMSTDNETLRVSADA--NATNALLSNFEDYLDELSPTILKLNTTIF 249
                 ||.:...::.|...||.:..:..:.:::.  .|.:.|:...|  .|..|.||...|..:
Zfish   581 -----NATLASTVVTIISNVMVSSEDAQKDASETALKAVDELVQKIE--FDGPSLTISSKNLVV- 637

  Fly   250 ANSTEFTFHPLFDMGVIVLKTSELRVFFVDPEVRNVSGIVNFSGGNMSHFEMLHLSDNEEDIRA- 313
                          ||..|.|:                  ||:|..:|.|...:.:|.:.|..:
Zfish   638 --------------GVSALDTT------------------NFNGSTLSAFIATNTTDPQIDFDSE 670

  Fly   314 MKNLESAVFIPEKLWTQL---KRKGASYLVFKVYTRDSLFVETEEE----IKRRPTSNVISITIP 371
            ..|..:.|.:|..|...|   :.:..|.:.|..:.|..||.:.:..    ......|:|.:.||.
Zfish   671 AHNALAVVTLPPTLLQNLSLSQIEKVSRINFMFFGRTGLFQDHQNNGLTLNSYVVASSVGNFTIK 735

  Fly   372 GLNDTKLPGKLPF-FLRNAKANETQFEGGCGYWNYET------WLSDGISTSGGGSLEASSHPVI 429
            .|.|   |.::.. .|...|....|    |.:|::..      |.|||...   ||...|:..|.
Zfish   736 NLQD---PVRIEIAHLEYQKDPNPQ----CVFWDFNLQNYSGGWNSDGCKV---GSDSNSNRTVC 790

  Fly   430 LCHADHLTQFTFLLGVSKMQAGLDTNEDDHSLDVITNVGLTLSLLGLLMIFITAAVFKSFRTLAS 494
            ||  :|||.|..|:.||: .|.|...:::..|..||.:|..:|.:......:|...|:..|....
Zfish   791 LC--NHLTHFGILMDVSR-AAELIDEKNNRVLTFITYIGCGISAIFSAATLLTYIAFEKLRRDYP 852

  Fly   495 TKILLNLCAALGLQLLFFLILSQSHLLE-QLEQSE-SERCTLVGAVMQYLLLVVFSWMFIIGFLQ 557
            :|||:||..:|       |.|:...||: .|...| .|.|..|...:.:.||..|:||.:.....
Zfish   853 SKILMNLSTSL-------LFLNMVFLLDGWLASYEIKELCVTVAVFLHFFLLTSFTWMGLESIHM 910

  Fly   558 YQRYVRVIGVNHPRHYILMSAVAAWTLPLIPTLLVVFLEPGSYRPN--NSSMDYPILCYPSGYGL 620
            |...|:|.. .:.|.|||...:..|.:|.....:|:.:...||..|  ....|        |.|.
Zfish   911 YIALVKVFN-TYIRRYILKFCIVGWGVPAAIVGIVLAVSKDSYGKNYYGKGKD--------GQGT 966

  Fly   621 S--LGVILPIGLITVANAILVGYIS--WSVYTALF------------------KRDLIFKQLGLF 663
            |  ..::.|:    |.....|.|.|  :.:..|:|                  .|:.|.:.|...
Zfish   967 SEFCWILNPV----VFYVTCVAYFSIIFLMNVAMFIVVMIQICGRNGKRSNRTLREDILRNLRSV 1027

  Fly   664 VLLFFLLGITWIFGLCTYFDFGRI---FAYLFCLTATLQGFVLFLYFIVFNKENQRAWLG-LCC- 723
            |.|.||||:||.|   .:|.:|.:   |.|||.:..:|||..:|::.....:..|:.|.. |||
Zfish  1028 VSLTFLLGMTWGF---AFFAWGPVSLAFMYLFTIFNSLQGLFIFVFHCALKENVQKQWRRYLCCG 1089

  Fly   724 ------NS--SKKRNQQTIQMPTDSILQGLSHSSTNSTS 754
                  ||  ||.....|.::.:|::.:.||.||..||:
Zfish  1090 KLRLADNSDWSKTATNNTKKVSSDNLGKSLSSSSFGSTT 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	68/250 (27%)
adgrg6	NP_001356058.1	CUB	41..146	CDD:278839
		LamG	153..336	CDD:354964
		GPS	756..801	CDD:334696	17/53 (32%)
		7tmB2_GPR126	816..1086	CDD:320662	76/292 (26%)
		TM helix 1	818..843	CDD:320662	6/24 (25%)
		TM helix 2	853..875	CDD:320662	10/28 (36%)
		TM helix 3	886..913	CDD:320662	7/26 (27%)
		TM helix 4	928..944	CDD:320662	2/15 (13%)
		TM helix 5	975..998	CDD:320662	6/26 (23%)
		TM helix 6	1021..1046	CDD:320662	11/27 (41%)
		TM helix 7	1050..1075	CDD:320662	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	115	1.000	Domainoid score	I5962
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	108	1.000	Inparanoid score	I4885
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.960