DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and adgrl3.1

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	XP_005170997.1	Gene:	adgrl3.1 / 560631	ZFINID:	ZDB-GENE-030131-7856	Length:	1540	Species:	Danio rerio

Alignment Length:	811	Identity:	185/811 - (22%)
Similarity:	302/811 - (37%)	Gaps:	212/811 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PPLYALDQPNVARCLDYC-------------HLKNLRFLLCVDADGQLSHNPYKDCNRGFCKAED 72
            ||     .|.....:|||             |            .||::..|   |..|......
Zfish   482 PP-----SPQTPVTVDYCAPRLTAEISWPRTH------------QGQVAKQP---CPPGTIGVAT 526

  Fly    73 FE--LEYETDEGKEKR------INRV-EKTRVGQKANL--RDLCLNERGIPIRRRCQIRNGNRVW 126
            |.  |.|...:|.:..      .|.: ::.|.|:.|.:  |:|....:|       ::|.|:
Zfish   527 FNCLLGYWDPKGPDLSNCTSPWTNHITQRMRSGETAAIVARELAEQTKG-------ELRPGD--- 581

  Fly   127 QSLDHVTCRSAPELSSSINLLAVKSPPDMISQLSNLLTQTQEKLAAADVFSISEIFDSLVKKPER 191
                  ...:...::..:.||.|        ||.||....::..|.    |::::     :|.||
Zfish   582 ------VPSTVKAMAQLVELLDV--------QLRNLTPGGKDTAAR----SLNKL-----QKRER 623

  Fly   192 NAAVVGDLMKICQKVMSTDNETLRVSADA-----------NATNALLSNFEDYLDELSPTILKLN 245
            :...      ..|.::.|.|..|:|.:.|           .....||...|.....|:..:||.:
Zfish   624 SCRF------FIQAMVETVNNLLQVRSQAAWRELSVAEQLRCATMLLDTVETGAFMLADNLLKTD 682

  Fly   246 TTIFANSTEFTFHPLFDMGVIVLKTSELRVFFVDPEVRNVSGIVNF-------SG--GNMSHFEM 301
            |                   |...|..:::     ||..:|..||.       ||  ||     .
Zfish   683 T-------------------IQESTDNIQL-----EVARLSTDVNLADLSFPQSGLTGN-----S 718

  Fly   302 LHLSDNEEDIRAMK------NLESAVFIPEKLWTQLKRKGASYLVFK--VYTRDSLFVETEEEIK 358
            :|||.|     .:|      .:..|:.:.:.|...|..:.||..:..  ||...||.|
Zfish   719 IHLSAN-----TLKQQGRNGEIRMALVLYKNLGQYLSTENASVRLGSEAVYPNYSLIV------- 771

  Fly   359 RRPTSNVISITI-PGLNDTKLPGKLPFFLRNAKANETQFEGGCGYWNYETWLSDGISTSGGGSLE 422
               .|.||:..| ...|...|...:.|.:::.:.:|..|...|.:|:|......|..::....|.
Zfish   772 ---NSPVITAAINKDSNKVYLSEPVVFTVKHIQQSEENFNPNCSFWSYSKRTMTGFWSTQDCRLL 833

  Fly   423 ASSHPVILCHADHLTQFTFLLGVSKMQAGLDTNEDD--HS--LDVITNVGLTLSLLGLLMIFITA 483
            .::.....|...|||.|..|:      |.::..:.|  |.  |||||.||:.|||:.||:...|.
Zfish   834 GTNRTHTSCSCTHLTNFAVLM------AHVEVKKADQVHELLLDVITWVGILLSLVCLLICIFTF 892

  Fly   484 AVFKSFRTLASTKILLNLCAALGLQLLFFLILSQSHLLEQLEQSESE-RCTLVGAVMQYLLLVVF 547
            ..|:..::..:| |..|||.:        |.::::..|..:.:::.. .|.:..|::.:..|..|
Zfish   893 CFFRGLQSDRNT-IHKNLCIS--------LFIAETLFLTGINRADQPIVCAVFAALLHFFFLAAF 948

  Fly   548 SWMFIIGFLQYQRYVRVIGVNHPR-HYILMSAVAAWTLPLIPTLLVVFLEPGSYRPNNSSMDYPI 611
            :|||:.|...|...|.|....:.| .|..::...      :|.::|.......||...:..
Zfish   949 TWMFLEGVQLYIMLVEVFESEYSRTKYFYLTGYG------VPAVIVAVSAAVDYRSYGTER---- 1003

  Fly   612 LCYPSGYGLSL------GVILPIGLITVANAILVGYISWSVY--TALFKRD------LIFKQLGL 662
            :|:     |.|      ..|.|..||.:.|.|.:|...:.::  ||:.|.|      :....:|.
Zfish  1004 VCW-----LRLDTYFIWSFIGPATLIIMLNVIFLGIALYKMFHHTAILKPDSGCLDNIKSWVIGA 1063

  Fly   663 FVLLFFLLGITWIFGLCTYFDFGRIFAYLFCLTATLQGFVLFLYFIVFNKENQRAWLGLCCNS-- 725
            ..|| .|||:||.|||....:...|.||||.:..:|||..:|::..:..|:.::.: |.|..:
Zfish  1064 IALL-CLLGLTWAFGLMYINESTVIMAYLFTIFNSLQGMFIFIFHCILQKKVRKEY-GRCLRTHC 1126

  Fly   726 -SKKRNQQTIQMPT-DSILQGLSHSSTNSTS 754
             |.|..:.||...| .|..:.....||||.|
Zfish  1127 CSGKSVESTISTSTKTSTARTPGRYSTNSQS 1157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	59/237 (25%)
adgrl3.1	XP_005170997.1	Gal_Lectin	66..146	CDD:280328
		OLF	160..415	CDD:128580
		HormR	493..553	CDD:214468	13/74 (18%)
		GAIN	562..780	CDD:293098	60/300 (20%)
		GPS	807..859	CDD:197639	13/57 (23%)
		7tm_2	868..1103	CDD:278432	71/259 (27%)
		Latrophilin	1124..1540	CDD:280509	11/34 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910