DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15556 and AgaP_AGAP000130

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	XP_001237342.3	Gene:	AgaP_AGAP000130 / 4576098	VectorBaseID:	AGAP000130	Length:	831	Species:	Anopheles gambiae

Alignment Length:	772	Identity:	221/772 - (28%)
Similarity:	351/772 - (45%)	Gaps:	156/772 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 RVGQKANLRDLCLNER-GIPIRRRCQIRNGNRV------WQSLDHVTCRSAPELSSSINLLAVKS 151
            |:|:....|:|||.|: |:|:.|||.   |:.:      |.....:........:|::...:|.|
Mosquito    83 RLGESVAPRNLCLIEQSGLPVTRRCL---GDYLYGCAWDWNPGSELCTGQHRPTTSALYQYSVTS 144

  Fly   152 PPDMISQLSNLLTQTQEKLAA------ADVFSISEIFDSLV---------KKPERNAAVVGDLMK 201
            ...  |.|..:||:..|.||.      ||:|.:|:..:::.         ...|...|...::..
Mosquito   145 LNH--SVLGEVLTRAGEILAVPEQVIPADLFYLSKTLENVPPVLEQSETGSPDEERRAYFCNVST 207

  Fly   202 ICQKVMSTDNETLRVSADA-NATNALLSNFEDYLDELSPTILKLNTTIFANSTEFTF-------- 257
            |..:||..:..|:.:|..| |.||.||...|..::.|:          .||.|....
Mosquito   208 ILSRVMYLNETTVVLSQRALNTTNILLDATETIVNRLA----------VANDTRAMMLAGDQYDC 262

  Fly   258 ---------HPLFDMGVIVLKTSELRVFFVDPEVRNVSGIVNFSGGNMSHFEM------------ 301
                     |.....|.::.:|:.|.|...||.|.||:|:..|...|:|..::
Mosquito   263 RDRGGAIQRHVQRHDGTVLFRTARLIVLIADPTVANVTGLALFRARNLSLEDLSDAAENSESEDD 327

  Fly   302 --------LHLSDNEEDIRAMKNLESAVFIPEKLWTQLKRKGASY-------------------- 338
                    |:::.:.||:.|..:||...|||:.:...|.....::
Mosquito   328 FSGYTLRYLYMNQSLEDLLAESDLEIGSFIPQHVIEGLDELNTAFRTPDDEEQDPDAPDESTTTL 392

  Fly   339 -------------------LVFKVYTRDSLFVETEEEIKRRPTSNVISITIPGLNDTKLPGKLPF 384
                               ::..:|..|..|.||:.....||.|.:||:::||.. :::|.::|.
Mosquito   393 PSPVEHPDPPVSPAPPPLRVIITIYYNDHAFRETKNGTIARPNSKIISVSLPGYG-SRMPDEIPI 456

  Fly   385 FLRNAKANETQFEGGCGYWNYETWLSDGISTSGGGS------LEASSHPVILCHADHLTQFTFL- 442
            :.|..   ..:....||||::|   :|..:..|..|      |.||...|.||...|||.|:.|
Mosquito   457 YTREM---ARELPSRCGYWSFE---ADNATEFGHWSYDECRLLNASDRGVSLCGCFHLTSFSRLT 515

  Fly   443 --------LGVSKMQAGLDTNEDDHSLDVITNVGLTLSLLGLLMIFITAAVFKSFRTLASTKILL 499
                    :|||:.   |..::...:||:||.:|.::||||::.||.|||:|.|:|..||:||||
Mosquito   516 QDIQMVETVGVSQK---LIADQGTLALDIITAIGCSMSLLGVMGIFATAALFPSWRVKASSKILL 577

  Fly   500 NLCAALGLQLLFFLILSQSHLLEQLEQSESERCTLVGAVMQYLLLVVFSWMFIIGFLQYQRYVRV 564
            .|..|:.::::  :|..:...::|...|:.| |.|:|.:..|::||.|.||.|..:||:.|||:|
Mosquito   578 QLSCAIAIEMI--IIFLEGPDIDQNRISQIE-CALLGGIFHYIILVTFMWMLITAYLQFMRYVKV 639

  Fly   565 IGVNHPRHYILMSAVAAWTLPLIPTLLVVFLEPGSYRPNNSSMDYPILCYPSGYGLSLGVILPIG 629
            :|...|.|:||.:.|..|..||:...|.:.|:...|...::..|   :|||.|..|..|::||||
Mosquito   640 LGQLRPAHFILKATVCCWGGPLLIVALFLSLDYTLYLKRDNLSD---ICYPHGRALWYGLLLPIG 701

  Fly   630 LITVANA---ILVGYISWSVYTALFK---RDLIFKQLGLFVLLFFLLGITWIFGLCTYFDFGRIF 688
            .|...|.   ::|.|...::.:.|.|   ..:...||.|.|.||||||:.||||:.|.....::|
Mosquito   702 AIIFVNLVSFVIVLYHICTIPSNLTKSADHAMTLAQLRLSVFLFFLLGLPWIFGMLTTGTEEKLF 766

  Fly   689 AYLFCLTATLQGFVLFLYFIVFNKENQRAWLGL-----CCNSSKKRNQQTIQMPTDS 740
            ||||||||.:||||||:||:|.:...:|.|...     ||.:...::....|..|.:
Mosquito   767 AYLFCLTAPVQGFVLFVYFVVMDPSARRFWCRKLQRLPCCRARPTKDADADQTTTSA 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	90/227 (40%)
AgaP_AGAP000130	XP_001237342.3	GPS	467..514	CDD:280071	18/49 (37%)
AgaP_AGAP000130	XP_001237342.3	7tm_4	537..781	CDD:304433	101/249 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	205	1.000	Domainoid score	I6217
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	289	1.000	Inparanoid score	I5199
OMA	1	1.010	-	-		QHG27373
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0010006
OrthoInspector	1	1.000	-	-		mtm9721
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X7093
TreeFam	1	0.960	-	-
	11	10.930