DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and CG11318

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster

Alignment Length:	820	Identity:	313/820 - (38%)
Similarity:	466/820 - (56%)	Gaps:	98/820 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WIAGYII---LVSGGTNPPLYALDQPNVARCLDYCHLKNLRFLLCVDADGQ---------LSHNP 59
            |.||..:   |||     |:|:........|     |:|..|..|   ||:         .:|..
  Fly     5 WCAGLFVVLALVS-----PIYSACPKENQMC-----LRNGTFQYC---DGEERNSSDELMQTHLV 56

  Fly    60 YKDCNRGFCKAEDFELEYET-DEGKEKRINRVEKTRVGQKANLRDLCLNERGIPIRRRCQIRNGN 123
            |  |...||:.|:|:.:|.| :..:....|:.::.|:|::|.|.|:||...|:|:.|.|::::..
  Fly    57 Y--CTSMFCEPEEFQHDYITRNHDQTPHQNKWKRARIGERATLHDVCLLRNGMPVTRECRVKDNR 119

  Fly   124 RVWQSLDH---VTC-RSAPE--LSSSINLL------------AVKSPPDMISQLSNLLTQTQEKL 170
            ..|:|.:|   |.| |...|  :|..:|.|            ..:...:|...:.|:..|....|
  Fly   120 ANWESTEHWDPVVCLRRFREHTISGDLNSLHDDVLEGRRRTNDTQGRREMTGIMRNMFRQRGGNL 184

  Fly   171 AAADVFSISEIFDSLVKKPERNAAVVGDLMKICQKVMSTDNETLRVSADANATNALLSNFEDYLD 235
            ..|||....::|.:|::: :::|.|..||:.:|:::||.|::.||:||..||||:|||.||.|:|
  Fly   185 LPADVHMTGQMFGALMQQ-DKDATVSVDLVSVCKEIMSCDSKVLRLSAQLNATNSLLSQFESYMD 248

  Fly   236 EL---------------SPTILKLNTTIFANSTEFTFHPLFDMGVIVLKTSELRVFFVDPEVRNV 285
            .|               .||..:..|.    :|....:...|:||..|.|..:.|||.:||...:
  Fly   249 ALPEQLVPKDRCGKVVAKPTSDEAETA----TTGVETYNFSDIGVQALITGNISVFFANPECDRI 309

  Fly   286 SGIVNFSG-GNMSH-------FEMLHLSDNEEDIRAMKNLESAVFIPEKLWTQLKRKGASYLVFK 342
            :|:..||. |:...       :..:..|::...::...|||:|.|:||.||.|:|.:||:||:||
  Fly   310 TGLAIFSAPGDQRKTSASGFWYRFIRFSEDLAKVKEESNLETAAFLPENLWRQVKSRGATYLIFK 374

  Fly   343 VYTRDSLFVETEEEIKRRPTSNVISITIPGLNDTKLPGKLPFFLRNAKANETQFE-----GGCGY 402
            ||..|:|||||..:..|:|.|.||||:||||....|...|||.|||........:     .||||
  Fly   375 VYAHDALFVETSLQRTRKPRSKVISISIPGLRSNYLSLPLPFLLRNENLRNPDSKAFSIGSGCGY 439

  Fly   403 WNYETWLSDGISTSGGGSLEASSHPVILCHADHLTQFTFLLGVSKMQAGLD-----TNEDDHSLD 462
            ||||||.::|:||.....|...:  :|.||.:|||||.||:|.|.....|.     |..::..||
  Fly   440 WNYETWSTEGVSTESSSDLLKDA--IIECHTNHLTQFAFLVGGSYRANDLGEEILITPINEKVLD 502

  Fly   463 VITNVGLTLSLLGLLMIFITAAVFKSFRTLASTKILLNLCAALGLQLLFFLILSQSHLLEQL-EQ 526
            :|:.||.:|||||:|.||:|||:|||:|:.||||:||:||.|:.||::.|:.|:...:.|.| ..
  Fly   503 IISIVGCSLSLLGILGIFLTAALFKSWRSQASTKVLLHLCLAMCLQMMLFVFLNTDDVSEALVVN 567

  Fly   527 SESERCTLVGAVMQYLLLVVFSWMFIIGFLQYQRYVRVIGVNHPRHYILMSAVAAWTLPLIPTLL 591
            ..:.||..:||.|||.:||:||||.||.|||:||||.|||:..|..|||.:|:.||.|||:||||
  Fly   568 GNTVRCVALGAAMQYSILVLFSWMLIIAFLQFQRYVTVIGIERPPRYILKAAIVAWLLPLVPTLL 632

  Fly   592 VVFLEPGSYRPNNSSMDYPI-LCYPSGYGLSLGVILPIGLITVANAILVGYISWSVYTALF---- 651
            |..::|.||.|:.:.:.... :||||||||..||:||:.||||.|.::..|:.:|:..:|.
  Fly   633 VALIDPDSYVPSAAQLSTDTGICYPSGYGLIFGVVLPVTLITVCNLVIFVYVFYSISHSLSQSIH 697

  Fly   652 --KRDLIFKQLGLFVLLFFLLGITWIFGLCTYFDFGRIFAYLFCLTATLQGFVLFLYFIVFNKEN 714
              ::.::.||:.|.::||||||:|||||:..:...|..|:||||:|||:||||:|:||::.:..|
  Fly   698 KNEKKMVVKQIRLSIMLFFLLGLTWIFGIFAFMQAGVAFSYLFCITATMQGFVMFIYFVLLDSTN 762

  Fly   715 QRAWLGLCCNSSKKRNQQTIQMPTDSILQGLSHSSTNSTS 754
            :|.|:||.|.:   :.:..:|..|.. ||.::.||||..|
  Fly   763 RRLWVGLICPT---KMELDVQKRTTE-LQSMTTSSTNYNS 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	112/229 (49%)
CG11318	NP_651842.3	GPS	437..475	CDD:280071	20/39 (51%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	124/249 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462136
Domainoid	1	1.000	115	1.000	Domainoid score	I5962
eggNOG	1	0.900	-	-		E1_KOG4193
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	289	1.000	Inparanoid score	I5199
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0010006
OrthoInspector	1	1.000	-	-		otm26373
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X7093
	9	8.890