DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15556 and celsr1a

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	XP_009298735.1	Gene:	celsr1a / 368436	ZFINID:	ZDB-GENE-030616-78	Length:	3045	Species:	Danio rerio

Alignment Length:	918	Identity:	193/918 - (21%)
Similarity:	319/918 - (34%)	Gaps:	277/918 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 NPPLYALDQPNVARCLDYCHLKNLRFL-LCV---------------DADGQLSHNPYK------- 61
            :|..:..|      |:|.|||.....| .||               |..||...|..:
Zfish  1916 DPGFFGRD------CVDACHLNPCEHLSTCVRKPSSSHGYTCECSQDYYGQYCENKVEKPCPRGW 1974

  Fly    62 -------------------DCNR--GFCKAEDFELEYETDE----------GKEKRINRVEKTR- 94
                               |||:  |.|:.:|...:.:..:          |...|....|..:
Zfish  1975 WGNPMCGPCNCDVSKGFNPDCNKTTGECRCKDNYYQPKDSDTCFPCDCFHLGANSRTCDPETGQC 2039

  Fly    95 ------VGQKANLRDLCLNE---------------------------RGIPIRRRC-------QI 119
                  :|::.|..|...:|                           .|.|:...|       .:
Zfish  2040 PCKAGVIGRQCNRCDNPFSEVTSTGCEVGYEGCPKAFDSGIWWPRTNFGFPVAMNCPKGSIGTAV 2104

  Fly   120 R--NGNRVWQSLDHVTC---------RSAPELSSSINLLAVKSPPDMISQLSNLLTQTQEKLAAA 173
            |  |..:.|...:...|         :...:|..:.:.:..:...|:...|.|...|| ......
Zfish  2105 RHCNDEKGWLPPELFNCTTITFSHLKKMNDDLHRNESSMDGQKSRDIARMLHNATDQT-SSFYGN 2168

  Fly   174 DVFSISEIFDSLVKKPER----NAAVVGD------LMKICQKVMSTDNETL--RVSADANATNAL 226
            |:.:...:..|:::...:    |.|.:.|      |:|....::...|:..  ::......|..|
Zfish  2169 DIKTTYHLLSSILRYESQQQGFNLAAMRDAKFNENLVKAGSAILDASNKEHWDQIQRTEGGTANL 2233

  Fly   227 LSNFEDYLDELSPTILKLNTTIFANSTEFTFHPLFDMGVIVLKTSELRVFFVD-----PEVRNVS 286
            |.:||:|.:.|:..:.|.....|               :||   :|..||.||     |:...|.
Zfish  2234 LKHFEEYANTLAQNMRKTYLKPF---------------IIV---TENMVFAVDYLVTYPDATKVP 2280

  Fly   287 GIVNFSGGNMSHFEMLHLSDNEEDIRAMKNLESAVFIP--------------------------E 325
               ||           ..:|.|    ..|:|:|:|..|                          |
Zfish  2281 ---NF-----------QTTDQE----CPKDLKSSVLFPEFSFKSSEHKVSPTDDPEFQINSDEEE 2327

  Fly   326 KLWTQLKRKG----------ASYLVFKVY----------TRDSLFVETEEEIKRRPTSN--VISI 368
            |..|. |||.          ||.:::|..          .|.||      .:..||..|  ::|.
Zfish  2328 KQATN-KRKRHVETIPPFPVASVIIYKTLGQFLPEHYDPDRRSL------RVPNRPVINTPIVSA 2385

  Fly   369 TIPGLND-TKLPGKLPFFL-RNAKANETQFEGGCGYWNYETWLSD-GISTSGGGSLEASSHPVIL 430
            |:..... ..:|.:.|..| .|....|.:.:..|.:||:...:.. |..:|.|..:.:.:|..|.
Zfish  2386 TVYSEGQPLHIPLERPITLDYNLLETEERTKPVCVFWNHSITVGGAGAWSSKGCDIISRNHTHIS 2450

  Fly   431 CHADHLTQFTFLLGVSKMQAGLDTNEDDHSLDVITNVGLTLSLLGLLMIFITAAVFKSFRTLAST 495
            |..:|:|.|..|:.:||.:.|     |...|.::|...::.|||.|.:.||..|:....|:...:
Zfish  2451 CQCNHMTSFAVLMDISKREHG-----DVLPLKIVTYTTVSASLLALFITFILLAILHKLRSNLHS 2510

  Fly   496 KILLNLCAALGLQLLFFLILSQSHLLEQLEQSESE-RCTLVGAVMQYLLLVVFSWMFIIGFLQYQ 559
             |..||.|||....|.|||        .:.|:::. .||::..::.|..:..|:|.|:.|...|:
Zfish  2511 -IHKNLVAALFFSELVFLI--------GINQTDNPFVCTVIAILLHYFYMCTFAWTFVEGLHIYR 2566

  Fly   560 RYVRVIGVNHPRHYILMSAVAAWTLPLIPTLLVVFLEPGSYRPNNSSMDYPILCYPSGYGLSL-- 622
            ....|..:|| .|.....|: .|.:|.|.|.|.|.|:|..|       ..|..|:.|.:...:
Zfish  2567 MLTEVRNINH-GHMRFYYAI-GWGIPAIITGLAVGLDPQGY-------GNPDFCWLSVHDTLIWS 2622

  Fly   623 --GVILPIGLITVANAILVGYISWSVYTALFKRDLIFKQLGLFVLLFFLLGITWIFGLCTYFDFG 685
              |.|..:.|:.:...::....|.......:::..:...|.:..||..|:..||:.||.......
Zfish  2623 FAGPIAVVVLVNIVIFVMAAKASCGRRQRSYEKSGVTPALRMAFLLLLLISATWLLGLMAVNSDV 2687

  Fly   686 RIFAYLFCLTATLQGFVLFLYFIVFNKENQRAWLGLCCNSSKKRNQQTI-----QMPTDSILQGL 745
            ..|.|||.:.:.|||..:|.:.||||||             .::|.:.:     |:|.:|
Zfish  2688 MTFHYLFAIFSCLQGVFIFFFHIVFNKE-------------VRKNLKNVFTGKKQLPDES----- 2734

  Fly   746 SHSSTNST 753
              |:|.:|
Zfish  2735 --STTRTT 2740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	58/226 (26%)
celsr1a	XP_009298735.1	Cadherin_repeat	257..356	CDD:206637
		Cadherin_repeat	364..464	CDD:206637
		Cadherin_repeat	473..553	CDD:206637
		Cadherin_repeat	578..675	CDD:206637
		Cadherin_repeat	684..777	CDD:206637
		Cadherin_repeat	786..880	CDD:206637
		Cadherin_repeat	889..986	CDD:206637
		Cadherin_repeat	994..1088	CDD:206637
		Cadherin_repeat	1108..1189	CDD:206637
		EGF_CA	1355..1390	CDD:238011
		EGF_CA	1400..1432	CDD:238011
		LamG	1435..1645	CDD:238058
		EGF	1671..1701	CDD:278437
		Laminin_G_2	1737..1869	CDD:280389
		TNFRSF	1901..2055	CDD:304602	25/144 (17%)
		CRD2	1942..2002	CDD:276900	8/59 (14%)
		EGF_Lam	2020..2065	CDD:214543	7/44 (16%)
		HormR	2069..2130	CDD:214468	7/60 (12%)
		GAIN	2148..2387	CDD:293098	56/282 (20%)
		GPS	2417..2462	CDD:280071	12/44 (27%)
		7tm_2	2474..2702	CDD:278432	63/245 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910