DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and Adgrl1

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	XP_030099484.1	Gene:	Adgrl1 / 330814	MGIID:	1929461	Length:	1543	Species:	Mus musculus

Alignment Length:	749	Identity:	157/749 - (20%)
Similarity:	259/749 - (34%)	Gaps:	209/749 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 ERGIPIRRRCQIRNGNRVWQSLDHVTCRSA--------PELSSS----INLLA--VKSPPDMISQ 158
            ::|:.:.|.|.  .|.|   .:....|..|        |:||:.    :|.:|  :||..:..:.
Mouse   566 QQGMLVERPCP--KGTR---GIASFQCLPALGLWNPRGPDLSNCTSPWVNQVAQKIKSGENAANI 625

  Fly   159 LSNLLTQTQEKLAAADVFSISEIFDSLVK---------KP-ERNAA------------VVGDLMK 201
            .|.|...|:..:.|.||.|..::.:.|:.         :| ||.:|            ...|.:|
Mouse   626 ASELARHTRGSIYAGDVSSSVKLMEQLLDILDAQLQALRPIERESAGKNYNKMHKRERTCKDYIK 690

  Fly   202 ICQKVMSTDN----ETLRVSADANATNAL--LSNFEDYLDELSPTILKLNTTIFANSTEFTFHPL 260
            ..  |.:.||    |.|....|.|||..:  .:...|.|:|        ...:.|::.......|
Mouse   691 AV--VETVDNLLRPEALESWKDMNATEQVHTATMLLDVLEE--------GAFLLADNVREPARFL 745

  Fly   261 FDMGVIVLKTSELRVFFVDPEVRNVSGIVNFSGGNMSHFEMLHLSDNEEDIRAMKNLESAVFIPE 325
            .....:||:.:          |.|..|.|.         |::...:...        |:::.:..
Mouse   746 AAKQNVVLEVT----------VLNTEGQVQ---------ELVFPQEYPS--------ENSIQLSA 783

  Fly   326 KLWTQLKRKGASYLVFKVYTRDSLFVETEEEIKRRPTSNVISITIPGLNDTKLPGKLPFFLRN-- 388
            ....|..|.|...:||.:|....||:.||.          .::.:.|...|..||.....:.:
Mouse   784 NTIKQNSRNGVVKVVFILYNNLGLFLSTEN----------ATVKLAGEAGTGGPGGASLVVNSQV 838

  Fly   389 --AKAN---------------------ETQFEGGCGYWNYETWLSDGISTSGGGSLEASSHPVIL 430
              |..|                     :..|...|.:|||......|..::.|..|..|:.....
Mouse   839 IAASINKESSRVFLMDPVIFTVAHLEAKNHFNANCSFWNYSERSMLGYWSTQGCRLVESNKTHTT 903

  Fly   431 CHADHLTQFTFLLGVSKMQAGLDTNEDDHSLDVITNVGLTLSLLGLLMIFITAAVFKSFRTLAST 495
            |...|||.|..|:...::..|   ..::..|.|||.||:.:||:.|.:...|....:..:|..:|
Mouse   904 CACSHLTNFAVLMAHREIYQG---RINELLLSVITWVGIVISLVCLAICISTFCFLRGLQTDRNT 965

  Fly   496 KILLNLCAALGLQLLFFLILSQSHLLEQLEQSESE-RCTLVGAVMQYLLLVVFSWMFIIGFLQYQ 559
             |..|||..|.|..|.||:        .:::::.| .|.:...::.|..|..|||:.:.|...|.
Mouse   966 -IHKNLCINLFLAELLFLV--------GIDKTQYEVACPIFAGLLHYFFLAAFSWLCLEGVHLYL 1021

  Fly   560 RYVRVIGVNHPR--HYILMSAVAAWTLPLIPTLLVVFLEPGSYRPNNSSM----DYPILCYPSGY 618
            ..|.|....:.|  :|.|    ..:..|.:...:...::..||....:..    :|.|..:
Mouse  1022 LLVEVFESEYSRTKYYYL----GGYCFPALVVGIAAAIDYRSYGTEKACWLRVDNYFIWSF---- 1078

  Fly   619 GLSLGVILPIGLITVANAI----------------------LVGYISWSVYTALFKRDLIFKQLG 661
                  |.|:..:.|.|.:                      |....||:              ||
Mouse  1079 ------IGPVSFVIVVNLVFLMVTLHKMIRSSSVLKPDSSRLDNIKSWA--------------LG 1123

  Fly   662 LFVLLFFLLGITWIFGLCTYFDFGRIFAYLFCLTATLQGFVLFLYFIVFNKENQRAWL-----GL 721
            ...|| ||||:||.|||........:.||||......||..:|::.....|:..:.:.     ..
Mouse  1124 AIALL-FLLGLTWAFGLLFINKESVVMAYLFTTFNAFQGVFIFVFHCALQKKVHKEYSKCLRHSY 1187

  Fly   722 CCNSSKKRNQQTIQMPTDSILQGLSHSSTNSTSI 755
            ||          |:.|     .|.:|.|..::::
Mouse  1188 CC----------IRSP-----PGGTHGSLKTSAM 1206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	57/250 (23%)
Adgrl1	XP_030099484.1	OLF	214..470	CDD:383019
		PLN02550	491..>573	CDD:178165	1/6 (17%)
		HormR	548..611	CDD:214468	10/49 (20%)
		GAIN	621..845	CDD:374574	51/270 (19%)
		GPS	869..921	CDD:197639	15/51 (29%)
		7tmB2_Latrophilin-1	928..1185	CDD:320673	68/294 (23%)
		TM helix 1	931..955	CDD:320673	10/23 (43%)
		TM helix 2	964..985	CDD:320673	10/29 (34%)
		TM helix 3	995..1017	CDD:320673	5/21 (24%)
		TM helix 4	1036..1052	CDD:320673	3/19 (16%)
		TM helix 5	1071..1094	CDD:320673	6/32 (19%)
		TM helix 6	1118..1143	CDD:320673	15/39 (38%)
		TM helix 7	1147..1172	CDD:320673	7/24 (29%)
		Latrophilin	1185..1543	CDD:367050	7/37 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810