DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15556 and adgrg1

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001018317.1	Gene:	adgrg1 / 324948	ZFINID:	ZDB-GENE-030131-3671	Length:	648	Species:	Danio rerio

Alignment Length:	770	Identity:	167/770 - (21%)
Similarity:	264/770 - (34%)	Gaps:	221/770 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LRFLLCVDADGQLSHN--PYKDCNRGFCKAEDFELEYETDEGKEKRINRVEKTRVGQKANLRDLC 105
            |.|:|     ||.:.|  .:|.|.:.........|||:...|.|         |:...||...|.
Zfish    17 LLFVL-----GQATDNDRDFKMCGKWLHGIAPQNLEYDLKTGCE---------RIEISANESTLS 67

  Fly   106 LNERGIPIRRRC----QIRNGNRVWQSLDHVTCRSAPELSSSINLLAVK---------SPPDMIS 157
            :..|   |..:|    .|:..:...|:..|......|.|    :||.|:         .|..:..
Zfish    68 IQGR---ITAKCTQSSSIQLDSNPHQNQSHFCVFWEPLL----DLLIVEVNGKNHTLCKPNGLQG 125

  Fly   158 QLSNLLTQ-TQEKLAAADVFSISEIFDSLVKKPERNAAVVGDLMKICQKVMSTDNETLRVSADAN 221
            .....|:| .|:.   |.::.|.            |.:|.||::
Zfish   126 TCCTDLSQGVQDN---AHMYGIV------------NGSVKGDII--------------------- 154

  Fly   222 ATNALLSNF----------EDYLDE--LSP--------TILKLNT-----------TIFANSTEF 255
             |..|..|:          |.:.||  |.|        .:::.|.           |:.....||
Zfish   155 -TGDLKGNYIFDGAHINCKEKFCDEARLKPRGANMIEEVVMRFNAKGRVDLPCAQGTVIEMDEEF 218

  Fly   256 TFHPLFDMGVIVLKTSELRVFFVDPEVRNVSGIVNFSGGNMSHFEMLHLSDNEEDIRAMKNLESA 320
            |.|.                 |..|..|.|..                            |...:
Zfish   219 TGHN-----------------FTVPAPRFVDA----------------------------NTIPS 238

  Fly   321 VFIPEKLWTQLKRKGASYLVFKVYTRDSLFVETEEEIKRRPTSNVISITIPGL---NDTKL---- 378
            |:||..|.:..:||  |.:|...|...:||       :|.|:.:.:...|.||   |:|..
Zfish   239 VYIPSSLRSVSRRK--SKVVCTYYKNKTLF-------ERGPSKSALLDDIVGLSVENETIRNLIE 294

  Fly   379 PGKLPFFLRNAKANETQFEGGCGYW-----NYETWLSDGISTSGGGSLEASSHPVILCHADHLTQ 438
            |.|:.|..|....:.:   |.|..|     |...|..||..|......:..      ||.:|||.
Zfish   295 PVKIRFHHRPFAPDSS---GRCVSWDTKQDNEVNWKDDGCDTVKINEEQTE------CHCNHLTY 350

  Fly   439 FTFLLGVSKMQAGLDTNEDDHSLDVITNVGLTLSLLGLLMIFITAAVFKSFRTLASTKILLNLCA 503
            |..|:.|.:.    .|.....:|..||.||..:||:..|::|......:..:....:.:...|..
Zfish   351 FAILVQVEQK----STVRHLKALTFITAVGCAVSLVSCLVLFYWLCKRRRGKKNQISLVHRGLVV 411

  Fly   504 ALGLQLLFFLILSQSHLLEQLEQSESERCTLVGAVMQYLLLVVFSWMFIIGFLQYQRYVRVIGVN 568
            |:.|..|||::   :.:|..:  :....|.|.|:::.|.||....||.:..|..:....:|..
Zfish   412 AIFLLCLFFIL---TGILANV--ANETVCQLTGSLLHYGLLSTLCWMAMEVFHTFLLVRKVFN-- 469

  Fly   569 HPRHYILMSAVAAWTLPLI----PTLLV-VFLEPG------SYRPNNSSMDYPILCY-PSGYGLS 621
                    |.:..|...|:    |.||| :.|..|      ..:|::...:...:|: ..|....
Zfish   470 --------SPLPIWIFYLMGFGFPFLLVSILLSVGDIYGERKIKPSDDVNNPYRMCWMTEGDKSQ 526

  Fly   622 LG-VILPIGLITVANAILVGYISWSVYTALFKRDLIFKQLGLFVL----LFFLLGITWIFGLCTY 681
            |. .|:.|||:.|  .:..|.:...:.....:....:|::.:..|    |..|.|.||..|...:
Zfish   527 LAHYIINIGLLAV--VVSSGLVMLFLVVREIRNRPDWKKIHVAFLSIWGLTCLYGTTWALGFLDF 589

  Fly   682 FDFGRIFAYLFCLTATLQGFVLFL-YFIV--FNKENQRAWLGLCCNSSKKRNQQT 733
            ..|..:..:|||:..:||||.|.| |:.:  ..|::..:..|....|||:...||
Zfish   590 GPFSEVTLFLFCIINSLQGFFLMLRYYALERMKKKDVSSSDGSSSGSSKQHMLQT 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	52/238 (22%)
adgrg1	NP_001018317.1	GPS	312..354	CDD:280071	13/47 (28%)
adgrg1	NP_001018317.1	7tm_4	369..611	CDD:304433	61/258 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X7093
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910