DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and Adgre1

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001007558.1	Gene:	Adgre1 / 316137	RGDID:	1359214	Length:	932	Species:	Rattus norvegicus

Alignment Length:	784	Identity:	165/784 - (21%)
Similarity:	302/784 - (38%)	Gaps:	185/784 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 NVARCLDYCHLKNLRFLLCVDADGQLSHNPYKDCNRGFCKAEDFELEYETDEGKEKRINRV--EK 92
            ::..|.|.|...:    .|.:..|..    :..|:.||..:.. :|.:...|...:.|:..  :.
  Rat   272 DIDECDDICPSNS----SCTNTLGSY----FCTCHPGFASSNG-QLNFTDQEVTCEDIDECTQDP 327

  Fly    93 TRVGQKANLRDLCLNERGIPIRRRCQIRNGNRV----WQSLDHVTCRSAPELSSSINLLAVKSPP 153
            .|.|:.::    |.|   :|....|......|:    .|:..:.||:..|          .|...
  Rat   328 FRCGRNSS----CTN---VPGSYNCSCLPDFRMDPGGSQAHGNFTCKRIP----------FKCKE 375

  Fly   154 DMISQLSNLLTQTQEKLAAADVFSISEIFDSLVKKPERNAAVVGDLMKICQKVMST--------D 210
            |:|.:                    ||..:.......||.    |....|..|.:|        :
  Rat   376 DLIPK--------------------SEQIEQCQAGQGRNL----DYTSFCTFVNATFTILDNTCE 416

  Fly   211 NETLRVSADANATNALLSNFEDYLDELSPTILKLNTTIFANSTEFTFHPLFDMGVIVLKT--SEL 273
            |::..||..:.||:..|             :|:..:|.|    ||:......:|.|:|:|  |.:
  Rat   417 NKSAPVSLQSAATSVSL-------------MLEQASTWF----EFSREETSTLGTILLETVESTM 464

  Fly   274 RVFFVDPEVRNVSGIVNFSGGNMS---HFEMLHLSD-------NEEDI------RAMKNLESAVF 322
            ....:.|            .||.|   ..|.|.:..       |||::      |..| ::...|
  Rat   465 LAALLTP------------SGNASQTIRTEYLEIESKVINEECNEENVSINLKARGDK-MDVGCF 516

  Fly   323 IPEKLWTQLKRKGASYLVFKVYTR-DSL-----FVETEEEIKRRPTSNVISITIPGLNDTKLPGK 381
            |.:    :.:..|...:.|..:.. ||:     |.:.:...|.|..|:|:..|:.|.........
  Rat   517 IIK----ESESTGTPGVAFVSFAHMDSVLDERFFEDGQASWKLRMNSHVVGGTVTGERKEDFSKP 577

  Fly   382 LPFFLRNAKANETQFEGGCGYWNYETWLSDGIST-SGGGSLEAS-SHPVILCHADHLTQFTFLLG 444
            :.:.|::.:..:......|..||  |.:.||..| ||..::||| :|.|  |..:.:|....::.
  Rat   578 IVYTLQHIQPKQKSERSICVSWN--TDVEDGRWTPSGCETVEASETHTV--CSCNRMTNLAIIMA 638

  Fly   445 VSKMQAGLDTNEDDHSLDVITNVGLTLSLLGLLMIFITAAVFKSFRTLASTKILLNLCAALGLQL 509
            ..::..       :.||.:|:.||..:||:.|.:...|..:|::.:. .:|.:.|:||..|.|..
  Rat   639 SGELTM-------EFSLYIISYVGTVISLVCLALAIATFLLFRAVQN-HNTYLHLHLCVCLFLAK 695

  Fly   510 LFFLILSQSHLLEQLEQSESE-RCTLVGAVMQYLLLVVFSWMFIIGFLQY--QRYVRVIGVNHPR 571
            :.|        |..::::::: .|.::...:.||.|..|.||.:...:.:  .|.::|:.....|
  Rat   696 ILF--------LTGIDKTDNQTACAIIAGFLHYLFLACFFWMLVEAVMLFLMVRNLKVVNYFSSR 752

  Fly   572 HYILMSAVA-AWTLPLIPTLLVVFLEPGSYRPNNSSMDYPILCY---PSGYGLS-LGVILPIGLI 631
            :..::...| .:.||::..::...:.|..|..:|.       |:   .:|:..| ||   |:.:|
  Rat   753 NIKMLHLCAFGYGLPVVVVIISATVHPWGYGMHNR-------CWLNTETGFIWSFLG---PVCMI 807

  Fly   632 TVANAILVGYISW-------SVYTALFK----RDLIFKQLGLFVLLFFLLGITWIFGLCTYFDFG 685
            ...|:.|:.:..|       ||.:.:.|    |.|.||.    :...|:||.:|:.|:.......
  Rat   808 ITINSALLAWTLWVLRQKLCSVNSEVSKLKDTRLLTFKA----IAQIFILGCSWVLGIFQIGPLA 868

  Fly   686 RIFAYLFCLTATLQGFVLFLYFIVFNKENQRAWLGLCCNSSKKRNQQTIQMPTDSILQGLSHSST 750
            .|.||||....:|||..:||...:.|::.:        :..:|...:...:.:.|...|:..||.
  Rat   869 SIMAYLFTTINSLQGAFIFLIHCLLNRQVR--------DEYRKLLTRKTDLSSHSQTSGILLSSM 925

  Fly   751 NSTS 754
            .|||
  Rat   926 PSTS 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	56/240 (23%)
Adgre1	NP_001007558.1	EGF_CA	33..63	CDD:238011
		EGF_CA	81..>109	CDD:214542
		EGF_CA	133..172	CDD:214542
		EGF_CA	173..>203	CDD:214542
		EGF_CA	222..255	CDD:214542
		cEGF	245..275	CDD:289433	0/2 (0%)
		EGF_CA	272..>301	CDD:214542	6/36 (17%)
		EGF_CA	319..359	CDD:284955	8/46 (17%)
		Cell attachment site. /evidence=ECO:0000255	507..509		1/1 (100%)
		GPS	592..641	CDD:197639	16/52 (31%)
		7tm_2	646..886	CDD:278432	64/262 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810