Protein Alignment CG15556 and ADGRE2

DIOPT Version :9

• Sequence 1: NP_001247379.1
• Gene: CG15556 / 43681
• FlyBaseID: FBgn0039821
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: XP_011526250.1
• Gene: ADGRE2 / 30817
• HGNCID: 3337
• Length: 837
• Species: Homo sapiens
• Alignment Length: 879
• Identity: 193/879 - (21%)
• Similarity: 309/879 - (35%)
• Gaps: 277/879 - (31%)

  Fly     6 WWIAG-YIILVSGGTNP----PLYALDQPNVARCLDYCHLKNLR----FLLCVDADGQLSHNPYK 61
            |...| |..:.|.|..|    ..:..:..|..:.:|.|. :|.|    :..||:..|..:    .
Human    86 WNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQ-QNPRLCKSYGTCVNTLGSYT----C 145

  Fly    62 DCNRGF-CKAEDFELEYETDEGKEKRINRVEKTRVGQK-ANLRDLCLNERGIPIRRRCQIRNGNR 124
            .|..|| .|.||           .|....|.:...||. .:....|||..|   ..:|:.|.|
Human   146 QCLPGFKLKPED-----------PKLCTDVNECTSGQNPCHSSTHCLNNVG---SYQCRCRPG-- 194

  Fly   125 VWQSL-------DHVTCRSAPELSSS----------INLLAVKS--------------------- 151
             ||.:       ::..|....|.||.          .|.:...|
Human   195 -WQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKDTV 258

  Fly   152 -----------PPDMISQ-LSNLLTQTQE-------KLAAADVFSISEIFDSLVKKPERNAAVVG 197
                       ||.:.|| ||....:.|:       .||...:.||.:..|.|::.|       |
Human   259 CEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDYKPGLANNTIQSILQALDELLEAP-------G 316

  Fly   198 DLMKICQKVMSTDNETL-RVSADANATNALLSNFEDYLDELSPTILKLNTTIFANSTEFTFHPLF 261
            ||            ||| |:.....|:: ||...||.|..||
Human   317 DL------------ETLPRLQQHCVASH-LLDGLEDVLRGLS----------------------- 345

  Fly   262 DMGVIVLKTSELRVFFVDPEVRNVS-GIVNFSGGNMSHFEMLHLSDNEEDIRAMKNLESAVFIPE 325
                                 :|:| |::|||          :.:..|..:...|.::.:|.:.:
Human   346 ---------------------KNLSNGLLNFS----------YPAGTELSLEVQKQVDRSVTLRQ 379

  Fly   326 KL------WTQLKRK---GASYL-------VFKVYTRDSLFVETEEEIKRRPT------------ 362
            ..      |.|.::.   |.|.:       :.|:.....|.:|.|:::....|
Human   380 NQAVMQLDWNQAQKSGDPGPSVVGLVSIPGMGKLLAEAPLVLEPEKQMLLHETHQGLLQDGSPIL 444

  Fly   363 -SNVISITIPGLNDTK-LPGKLPFFLRNAKANETQ---------FEGGCGYWNYETWLSDGISTS 416
             |:|||..:.. |||: |...:.|...:......|         .:.|||:     |.:.|.||.
Human   445 LSDVISAFLSN-NDTQNLSSPVTFTFSHRSVIPRQKVLCVFWEHGQNGCGH-----WATTGCSTI 503

  Fly   417 GGGSLEASSHPVILCHADHLTQFTFLLGVSKMQAGLDTNEDDHSLDVITNVGLTLSLLGLLMIFI 481
              |:.:.|:    :|...||:.|..|:      |..|..|:|..|.|||.:||::|||.||:..:
Human   504 --GTRDTST----ICRCTHLSSFAVLM------AHYDVQEEDPVLTVITYMGLSVSLLCLLLAAL 556

  Fly   482 TAAVFKSFR-TLASTKILLNLCAALGLQLLFFLILSQSHLLEQLEQSESERCTLVGAVMQYLLLV 545
            |..:.|:.: |..|..:.|:||..|. .|||.:.:.|:        .....|:::...:.||.|.
Human   557 TFLLCKAIQNTSTSLHLQLSLCLFLA-HLLFLVAIDQT--------GHKVLCSIIAGTLHYLYLA 612

  Fly   546 VFSWMFIIGFLQY--QRYVRVIGVNHPRHYI--LMSAVAAWTLPLIPTLLVVFLEPGSYRPNNSS 606
            ..:||.:.....:  .|.:.|:..:....::  ||..| .:.:|.:...:.....|..|
Human   613 TLTWMLLEALYLFLTARNLTVVNYSSINRFMKKLMFPV-GYGVPAVTVAISAASRPHLY------ 670

  Fly   607 MDYPILCY--PSGYGLSLGVILPIGLITVANAILVGYISW-----------SVYTALFKRDLIFK 658
             ..|..|:  |. .|...|.:.|:..|...|.:|.....|           .|.|....|.|.||
Human   671 -GTPSRCWLQPE-KGFIWGFLGPVCAIFSVNLVLFLVTLWILKNRLSSLNSEVSTLRNTRMLAFK 733

  Fly   659 ---QLGLFVLLFFLLGITWIFGLCTYFDFGRIFAYLFCLTATLQGFVLFLYFIVFNKENQRAWLG 720
               ||       |:||.||..|:.......|:.||||.:..:|||..:||.:.:.:::.:..:
Human   734 ATAQL-------FILGCTWCLGILQVGPAARVMAYLFTIINSLQGVFIFLVYCLLSQQVREQY-- 789

  Fly   721 LCCNSSKKRNQQTIQMPTDSILQGLSHSSTNSTS 754
                  .|.::...::.|:|.:..||.|:...||
Human   790 ------GKWSKGIRKLKTESEMHTLSSSAKADTS 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	58/242 (24%)
ADGRE2	XP_011526250.1	EGF_CA	67..117	CDD:284955	7/30 (23%)
		EGF_CA	119..154	CDD:238011	10/39 (26%)
		EGF_CA	163..210	CDD:284955	12/52 (23%)
		EGF_CA	212..246	CDD:284955	5/33 (15%)
		GPS	479..529	CDD:197639	15/66 (23%)
		7tm_4	533..774	CDD:304433	70/265 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810