DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and Adgrg7

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001100568.1	Gene:	Adgrg7 / 304014	RGDID:	1307217	Length:	785	Species:	Rattus norvegicus

Alignment Length:	800	Identity:	175/800 - (21%)
Similarity:	290/800 - (36%)	Gaps:	234/800 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 RINR-----VEKTRV------GQKANLRDLCLNE-RGIPIRRRCQIRNGNRVWQSLDHVTCRSAP 138
            ||||     |..|.|      |...|.|.:|..| ||:    ||.|.|           .|
  Rat    35 RINRGSSVSVSSTPVQFCRNGGTWQNGRCICTEEWRGL----RCTIAN-----------FC---- 80

  Fly   139 ELSSSINLLAVKSP------------PDMISQLSNLLTQTQEKLAAADVFSISEIFDSLVKKPER 191
            |.|:.:|....|.|            |:.:    |.......:|.....:.:.|..:..:...::
  Rat    81 ENSTFMNFTFGKIPVGRYGPSFQICGPNTV----NAGQPQATRLCGVSEYGVIEALNVTIGNCDK 141

  Fly   192 NAAV----VGDLMKICQ------KVMSTDNETLRV------------------SADANATNALLS 228
            |..:    :.|:....|      :|::||...|..                  :|::.|....::
  Rat   142 NLEILEKQINDISNNSQNISSDAQVLTTDASKLTAENITSATTVVGQIFNKTRNANSEAKKVAVT 206

  Fly   229 NFEDYLDELSPTILKL----NTTIFANSTEFTFHPLFDMGVIVLKTSELRVFFVDPEVRNVSGIV 289
            .....||.......|.    |:..|:|..|...:..|.:|...:         |:|.|...|...
  Rat   207 TVSQILDASEDVFQKAAENDNSNSFSNLIEQMENYSFSLGDEAV---------VEPNVAIQSVSR 262

  Fly   290 NFSGGNMSHFEMLHLSDNEEDIRAMKNLESAVFIPEKLWTQLKRKGASYLV-------------F 341
            |...|....|.:...|.:     ::.:.|:::   .|...:||..|.:.|.             |
  Rat   263 NSDSGPSVLFSVQKGSSD-----SLVSSETSI---NKTADELKPDGQTELQILLNTGGNKNSCGF 319

  Fly   342 KVYTRDSLF----VETEEEIKRRPTSNVISITIPGLNDTKLPGKLPFFLRNAKANETQFE---GG 399
            .||....||    .....:..::..|:.::.:....|:..:  |:.|   |...::.:|:   ..
  Rat   320 VVYQNHKLFQSKTFTATSDFSQKIISSKVNASEQEQNNVSV--KMVF---NPTYDKREFQLYSYA 379

  Fly   400 CGYWNY--ETWLSDGISTSGGGSLEASSHPVILCHADHLTQFTFLLGVSKMQAGLDTNEDDH--- 459
            |.|||.  :.|.:.|...    |:.||.  .:.|..:|.|.|..|:...|          |:
  Rat   380 CVYWNILKKDWDTAGCQK----SVNASG--FLGCQCNHTTNFAVLMSFKK----------DYKYP 428

  Fly   460 -SLDVITNVGLTLSLLGLLMIFITAAVFKSFRTLASTKILLNLC-AALGLQLLFFLILSQSHLLE 522
             ||||::|:|..||:.||.:..:...:.:..|..:.|.:|::|| :.|...|||...:..|:  :
  Rat   429 KSLDVLSNIGCALSIAGLAITILFQILTRKIRKTSVTWVLVSLCISMLIFNLLFVFGIENSN--K 491

  Fly   523 QLEQSESE---------------------RCTLVGAVMQYLLLVVFSWMFIIGFLQYQRYVRVIG 566
            .|:.|:|.                     .||.:.|::.|.||..|:|.   |....|.|..:|.
  Rat   492 NLKTSDSNINANPNENKIPETDTIETPNPSCTAIAALLHYFLLGTFTWN---GLSATQLYFLLIR 553

  Fly   567 VNH--PRHYILMSAVAAWTLPLI---PTLLVVFLEPGS-------YR----------PNNSSMDY 609
            ...  |||:|::.::..|.:|.|   .|:.:::...|:       ||          .||.....
  Rat   554 TMKPLPRHFIVIISLVGWGVPAIIVGVTIGIIYALSGNKSYWELDYRQEEICWLAVPKNNDFARS 618

  Fly   610 PILCYPSGYGLSLGVILPIGLITVANAILVGYISWSV-------YTALFKRDLIFKQLG-LFVLL 666
            |:|         ...|:|:.:|.:.|..:...|:..|       .|:..|...:.|.|. |.:.:
  Rat   619 PLL---------WSFIMPVTIILITNIAIFVIITVKVLWKNNQNLTSTKKVSSLKKVLSTLSIAV 674

  Fly   667 FFLLGITWIFG---LCTYFDFGRIFAYLFCLTATLQGFVLFLYFIVFNKENQRAWLGLCCNSSKK 728
            .|  |:||||.   |....|...:|:|:|||..|.||..:|:.:.|..|..|        |.:.|
  Rat   675 VF--GVTWIFAYAMLINNDDIRIVFSYIFCLFNTTQGLQIFILYTVRTKVFQ--------NEASK 729

  Fly   729 RNQQTIQMPTDSILQGLSHS 748
                        ||:.||.|
  Rat   730 ------------ILKSLSSS 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	67/276 (24%)
Adgrg7	NP_001100568.1	GPS	378..418	CDD:396408	13/45 (29%)
		7tmB2_GPR128	428..727	CDD:320385	82/322 (25%)
		TM helix 1	431..455	CDD:320385	9/23 (39%)
		TM helix 2	465..486	CDD:320385	8/20 (40%)
		TM helix 3	523..545	CDD:320385	8/24 (33%)
		TM helix 4	565..581	CDD:320385	3/15 (20%)
		TM helix 5	617..640	CDD:320385	6/31 (19%)
		TM helix 6	666..688	CDD:320385	8/23 (35%)
		TM helix 7	695..720	CDD:320385	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I6879
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910