DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15556 and Adgrg3

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	XP_038954076.1	Gene:	Adgrg3 / 291854	RGDID:	1305674	Length:	574	Species:	Rattus norvegicus

Alignment Length:	745	Identity:	158/745 - (21%)
Similarity:	268/745 - (35%)	Gaps:	242/745 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLFL-------WWIAGYIILVSGGTN--PPLYALDQPNVARCLDYCHLKNLRFLLCVDADGQLS 56
            :||||       |..|||    :|..|  ||...:| |.||.                :.:|:..
  Rat     9 LLLFLLLTSGVSWGRAGY----AGQANKPPPNGEVD-PVVAD----------------ENNGEEP 52

  Fly    57 HNPYKDCNRGFCKAEDFELEYETDEGKEKRINRVEKTRVGQKANLRDL--CLNERGIPIRRRCQI 119
            .||.:.  |..|:.:: :.||.|                   .:|.|:  |..:.|......|::
  Rat    53 RNPEEP--RNVCRLKE-DYEYNT-------------------FDLSDIAQCFTKCGQSDTNSCEV 95

  Fly   120 RNGNRVWQSLDHVTCRSAPELSSSINLLAVKSPPDMISQLSNLLTQTQEKLAAADVFSISEIFDS 184
            .|..|.|.:.:.....::.|   ::::..||      :.:.|:.|...|           ::..|
  Rat    96 GNLQRYWLNYESHLLENSME---TVDMPFVK------ALIQNISTDVSE-----------DLLYS 140

  Fly   185 LVKKPERNAAVVGDLMKICQKVMSTDNETLRVSADANATNALLSNFEDYLDELSPTILKLNTTIF 249
            ||..            :|.::||..:::    .||.                     ::|..::|
  Rat   141 LVPS------------QIPRQVMRGEDQ----PADR---------------------VRLPKSLF 168

  Fly   250 ANSTEFTFHPLFDMGVIVLKTSELRVFFVDPEVRNVSGIVNFSGGNMSHFEMLHLSDNEEDIRAM 314
                          |.:....|.:|:...         |:|...||
  Rat   169 --------------GALPGNRSAVRLAIT---------ILNIGPGN------------------- 191

  Fly   315 KNLESAVFIPEKLWTQLKRKGASYLVFKVYTRDSLFVETEEEIKRRPTSNVISITIPGLNDTKL- 378
                  ||...:|   |:.||:|.|                      .:.::.:::..::.|.|
  Rat   192 ------VFKGPRL---LEDKGSSVL----------------------NNRMVGLSVGQMHATGLS 225

  Fly   379 -PGKLPFFLRNAKANETQFEGGCGYWNYE--TWLSDGISTSGGGSLEASSHPVILCHADHLTQFT 440
             |.::.|..::...|...   .|.:|:..  .|.|.|.||..|...       .:|..||||.|.
  Rat   226 EPVEITFSHQHQSPNVIL---TCVFWDMAKGDWDSHGCSTEPGDGR-------TVCRCDHLTFFA 280

  Fly   441 FLLGVSKMQAGLDTNEDDHSLDVITNVGLTLSLLGLLMIFITAAVFK----SFRTLASTKILLNL 501
            .||..:..||...|      |..|:..|..:|::.|....:....|:    .|::..:.||.:.|
  Rat   281 LLLRPTLDQATART------LTRISQAGSAVSMIFLAFTMVLYVAFRFSLQRFKSEDAPKIHMAL 339

  Fly   502 CAALGLQLLFFLILSQSHLLEQLEQSESERCTLVGAVMQYLLLVVFSWMFIIGFLQYQRYVRVIG 566
            ..:|.|..|.|||...|.     .|.....|.:..|:..|.||.||:||.:..|..|...::|..
  Rat   340 STSLFLLNLTFLINVGSG-----SQGPPASCWVRAAIFHYFLLCVFTWMGLEAFHLYLLVIKVFN 399

  Fly   567 VNHPRHYILMSAVAAWTLPLIPTLLVVFL-EPGSY-------RPNNSSMDYPILCY----PSGYG 619
             .:..||.|..::..|.||:   |:|:.: ...||       :.|.:|::   ||:    |:.|.
  Rat   400 -TYFGHYFLKLSLLGWGLPV---LIVIGVGSSNSYGVYTIRDQENRTSLE---LCWFQKEPALYA 457

  Fly   620 LSLGVILPIGLITVANAILVGYISWSVY-----TALFKRDLIFKQLGLFVLLFFLLGITWIFGLC 679
            ...|..|...|.   .|:::..::|.::     ||...:...:|.:...:.|..|:|:||  ||.
  Rat   458 TVHGYFLVTFLF---GAVVLAMVAWKIFTLPSVTAGKGQGQTWKSVLTVLGLSSLVGMTW--GLA 517

  Fly   680 TYFDFGRIFAYLFCLTATLQGFVLFLYFIV 709
            .....|....|:|.|..:|||..:|.:||:
  Rat   518 VLTPLGLSTVYIFTLLNSLQGLFIFCWFII 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	63/242 (26%)
Adgrg3	XP_038954076.1	GPS	244..282	CDD:396408	14/44 (32%)
		7tm_GPCRs	292..551	CDD:421689	72/279 (26%)
		TM helix 1	294..319	CDD:410628	6/30 (20%)
		TM helix 2	333..355	CDD:410628	9/21 (43%)
		TM helix 3	366..393	CDD:410628	10/26 (38%)
		TM helix 4	406..426	CDD:410628	6/22 (27%)
		TM helix 5	454..481	CDD:410628	6/29 (21%)
		TM helix 6	495..522	CDD:410628	8/28 (29%)
		TM helix 7	524..549	CDD:410628	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I6879
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910