DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and ADGRD1

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001317426.1	Gene:	ADGRD1 / 283383	HGNCID:	19893	Length:	906	Species:	Homo sapiens

Alignment Length:	760	Identity:	157/760 - (20%)
Similarity:	281/760 - (36%)	Gaps:	177/760 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 RNGNRVWQS--------LDHV--TCRSAPELSSSIN-LLAVKSPPDMISQ-----LSNLLTQTQE 168
            |:.:..|::        ..||  |.:|...|...:| .|:...|...:|:     ..||:..:::
Human   182 RDNSMTWEASFSPPGPYWTHVLFTWKSKEGLKVYVNGTLSTSDPSGKVSRDYGESNVNLVIGSEQ 246

  Fly   169 KLA------AADVFSISE----------IFDSLVKKPERNAAVVGDLM--KICQKVMSTDNETLR 215
            ..|      |.|.|.|.|          .|.:.:.|....::.:..|.  .....||.||
Human   247 DQAKCYENGAFDEFIIWERALTPDEIAMYFTAAIGKHALLSSTLPSLFMTSTASPVMPTD----- 306

  Fly   216 VSADANATNALLSNFED-------------YLDELS----------PTILKLNTTIFANSTEFTF 257
                  |.:.:::|..:             ||..:|          .|.|.|..|......|...
Human   307 ------AYHPIITNLTEERKTFQSPGVILSYLQNVSLSLPSKSLSEQTALNLTKTFLKAVGEILL 365

  Fly   258 HPLFDMGVIVLKTSELRVFFVDPEVRNVSGIV--NFSGGN----------MSHF---EMLHLSDN 307
            .|    |.|.|......|..:...:..|.|.|  |..|..          |:.|   ::|..:.|
Human   366 LP----GWIALSEDSAVVLSLIDTIDTVMGHVSSNLHGSTPQVTVEGSSAMAEFSVAKILPKTVN 426

  Fly   308 EEDIRAMKNLESAVFIPEK-----LWTQ---LKRKGASYLVFKVYTRDSLFVET--EEEIKRRPT 362
            ....|...:.:|.:.||.:     .|:.   |......|.:..::...:...|.  .::.....|
Human   427 SSHYRFPAHGQSFIQIPHEAFHRHAWSTVVGLLYHSMHYYLNNIWPAHTKIAEAMHHQDCLLFAT 491

  Fly   363 SNVISITI--PGLNDTKLPGKLPFFLRNAKANETQFEGG------------CGYWNYETWLSDGI 413
            |::||:.:  |......|.|. |....:.|...|:.:..            |.:.::.:  .:|:
Human   492 SHLISLEVSPPPTLSQNLSGS-PLITVHLKHRLTRKQHSEATNSSNRVFVYCAFLDFSS--GEGV 553

  Fly   414 STSGGGSLEASSHPVILCHADHLTQFTFLLGVSKMQAGLDTNEDDHSLDVITNVGLTLSLLGLLM 478
            .::.|.:|...:....:|...|||.|..|:.|..::.   ......:|..|:.||.:||:|.|:.
Human   554 WSNHGCALTRGNLTYSVCRCTHLTNFAILMQVVPLEL---ARGHQVALSSISYVGCSLSVLCLVA 615

  Fly   479 IFITAAVFKSFRTLASTKILLNLCAALGLQLLFFLILSQSHLL--EQLEQSESERCTLVGAVMQY 541
            ..:|.||..|..|:.:.:..::      ..|.|.::::|..||  .:||...:. |.::..::.|
Human   616 TLVTFAVLSSVSTIRNQRYHIH------ANLSFAVLVAQVLLLISFRLEPGTTP-CQVMAVLLHY 673

  Fly   542 LLLVVFSWMFIIGFLQYQRYVRVIGVNHPRH--YILMSAVAAWTLPLIPTLLVVFLEPGSYRPNN 604
            ..|..|:||.:.|...|...::|.|....:|  |..|    .|..||:..::.:.....||..:|
Human   674 FFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGM----GWGFPLLICIISLSFAMDSYGTSN 734

  Fly   605 SSMDYPILCYPSGYGLSLG------------VILPIGLITVANAILVGYISWSVY-----TALFK 652
            :       |:.|   |:.|            :::.||:: :|...::..||...|     .:.||
Human   735 N-------CWLS---LASGAIWAFVAPALFVIVVNIGIL-IAVTRVISQISADNYKIHGDPSAFK 788

  Fly   653 RDLIFKQLGLFVLLFFLLGITWIFGLCTYFDFGRIFAYLFCLTATLQGFVLFLYFIVFN------ 711
              |..|.:   .:|..:||.:|:||:........:|.|:|....:|||..:||:..:.|
Human   789 --LTAKAV---AVLLPILGTSWVFGVLAVNGCAVVFQYMFATLNSLQGLFIFLFHCLLNSEVRAA 848

  Fly   712 -KENQRAWLGLCCNSSKKRNQQTIQMPTDSILQGLSHSSTNSTSI 755
             |...:.| .|..:|::..|.:    |..|.|...:.....||.:
Human   849 FKHKTKVW-SLTSSSARTSNAK----PFHSDLMNGTRPGMASTKL 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	57/242 (24%)
ADGRD1	NP_001317426.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810