DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and CG15744

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_572870.2	Gene:	CG15744 / 2768909	FlyBaseID:	FBgn0030466	Length:	1797	Species:	Drosophila melanogaster

Alignment Length:	783	Identity:	145/783 - (18%)
Similarity:	247/783 - (31%)	Gaps:	271/783 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 YKDCNRGFCKAEDFELEYETDEGKEKRINRV-----------EKTRVGQKANL------------ 101
            |:|..:.|... :.|..:.||.|..:.|.|:           :.|...|:|||
  Fly   285 YQDPTKVFGDV-NLETRHSTDSGILQSILRIASLTQNHTGMWDCTLRSQQANLSQAIVLHVVAKG 348

  Fly   102 ------RDLCLNE---------RGIPIRRRC--------QIRNGNR------VWQSLDHVTCRSA 137
                  |.:..|:         ||..:.:.|        |.|..:.      .|.:||..:|...
  Fly   349 TLYCEARVVHTNKGTYHWPRTMRGETVLQECVEEPSDATQARRASHECGPSGEWLNLDTESCVYV 413

  Fly   138 PELS------SSINLLAVK--SPPDMISQLSNLLTQTQEKL-AAADVFSISEIFDSLVK------ 187
            .|.:      :.:||...|  :..::..:|.| .||.|.:| ...|...:..|..:|||
  Fly   414 SETTRILEQFAKVNLTLTKGQNALEIARRLHN-FTQAQTQLNRIRDPMDLEYIARTLVKYLDQLE 477

  Fly   188 KPERNAAVVGDLMKICQKVMSTDNETLRVSADANAT----------------------------- 223
            :|::...:...||.|..::::......|.:.....|
  Fly   478 QPQQQQEISHLLMDIVSQLLNLPAHLFRAAQSEQGTGQRLLHVVESSAMRLALASTQAEPLPAEM 542

  Fly   224 -----------NALLSNFEDYLD----------ELSPTILKLNTTIFANSTEFTFHPLFDMGVIV 267
                       |..:..|...||          |.||...:.|:   ||.|    .|:::.|.|
  Fly   543 IPWRGSLAQQRNLFVEFFNISLDAFVSLSCVWLEQSPRGFQCNS---ANDT----IPMYEHGDI- 599

  Fly   268 LKTSELRVFFVDPEVRNVSGIVNFSGGNMSHFEMLHLSDNEEDIRAMKNL-ESAVFIPEKLWTQL 331
                       |..::....::    ||.|  ..|..:.....:|.|.:| .:...:|....:..
  Fly   600 -----------DAAIQLPYSVI----GNSS--TTLPATTTIRSLRLMISLHRNGKLLPNLRGSHN 647

  Fly   332 KRKGASYLVFKVYTRDSLF--------VETEEEI---------KRRPTSNVISITIPGLNDTKLP 379
            :...::.:....|:.|...        ::.||::         :..|..|.:|...|...|
  Fly   648 ESLSSAIIGILAYSSDGEALQFRADNELDPEEDVYQQRVTVMLRAHPYHNPLSAPQPAWWD---- 708

  Fly   380 GKLPFFLRNAKANETQFEGG-C-GYWNYETWLSDGISTSGGGSLEASSHPVILCHADHLTQF--- 439
                       |:|.::|.. | .::.:.|.:....|.:|        :..:|..:.:|..|
  Fly   709 -----------ADEQRWETSVCQQHYQHRTLVMFSCSRTG--------YYGLLQRSQYLNDFRSE 754

  Fly   440 ----TFLLGVSKMQAGLDTNEDDHSLDVITNVGLTLSLLGLLMI-----FITAAVFKSFRTLAST 495
                .|....:.:.||                      .|||..     .:|.|||.  |.:...
  Fly   755 ESGARFRHPPAAVYAG----------------------CGLLFACCAFNAVTFAVFG--RAVRIN 795

  Fly   496 KI----LLNLCAALG-LQLLFFLILSQSHLLEQLEQSESERCTLVGAVMQYLLLVVFSWMFIIGF 555
            ::    |:|...||| |.|.|.|.:.|:        :...:|.|:|.:|.||.|.|..|:.:...
  Fly   796 RVQRHALVNTWLALGALALAFSLGIYQT--------ASQPQCRLLGLLMHYLGLCVLLWVCVSLS 852

  Fly   556 LQYQRYVRVIGVNHPRHYILMSAVAAWTLPLIPTLLVVFLEPG-SYRPNNSSMDYPIL-CYPSGY 618
            ..|:|..:.......:.                        || ...|.......||| .|..|:
  Fly   853 SMYKRLTKTTTSGQGQC------------------------PGQDMEPQRERERKPILGIYLVGW 893

  Fly   619 GLSLGVILPIGLITVANAILVGYISWSVYTALFKRDLIFKQLGLFVLLFFLLGITWIFGLCTYFD 683
            |::|   |..|:.:..|  |..|.::. |..|.....:...|...|:|....|   |..||.|:.
  Fly   894 GIAL---LICGISSAVN--LAEYATYD-YCFLHSSTTLNALLVPAVILVIFCG---ILALCIYYQ 949

  Fly   684 FGR 686
            ..:
  Fly   950 LSQ 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	51/213 (24%)
CG15744	NP_572870.2	LRR_8	107..168	CDD:290566
		LRR_4	107..147	CDD:289563
		leucine-rich repeat	109..133	CDD:275378
		leucine-rich repeat	134..157	CDD:275378
		LRRCT	166..216	CDD:214507
		IG_like	229..344	CDD:214653	14/59 (24%)
		HRM	<366..412	CDD:295297	9/45 (20%)
		7tm_4	768..>975	CDD:304433	56/250 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462135
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930