DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and Adgre5

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_036055.2	Gene:	Adgre5 / 26364	MGIID:	1347095	Length:	818	Species:	Mus musculus

Alignment Length:	854	Identity:	174/854 - (20%)
Similarity:	285/854 - (33%)	Gaps:	278/854 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 FLLCVDADGQLSHNPYKDCNRGF---CKAEDFELEYE----------------------TDEGK- 83
            |.:|.:::|..:    ..||.|:   ..||.|..|.|                      |..|.
Mouse    83 FAMCKNSEGSYT----CVCNLGYKLLSGAESFVNESENTCQASVNTGMTPVPSRIHTVTTAPGNL 143

  Fly    84 EKRINRVEKTRVG--QKANLRDL---------------CLNERGIPIRRRCQIRNGNRVWQSLD- 130
            .::...|.:|::|  ::...:|:               |:|:.|   ...|..|.|   |:.:.
Mouse   144 PEQTTTVHQTQMGDSEERTPKDVNECISGQNHCHQSTHCINKLG---GYSCICRQG---WKPVPG 202

  Fly   131 ------HVTCRSAPELSSS----INLLAVKSP---------------------PDMISQ------ 158
                  ...|....|.||.    .|....|:.                     ||.|.|
Mouse   203 SPNGPVSTVCEDVDECSSGQHQCHNSTVCKNTVGSYKCHCRPGWKPTSGSLRGPDTICQEPPFPT 267

  Fly   159 ------------------LSNLLTQTQEKLAAADVFSISEIFDSLVKKPERNAAVVGDLMKICQK 205
                              :.|||...........:..:.|..|.|::.|
Mouse   268 WTLLPTAHSQTLLRFSVEVQNLLRDFNPATVNYTIQKLIEAVDKLLEDP---------------- 316

  Fly   206 VMSTDNETLRVSADANATNALLSNFEDYLDELSPTILKLNTTIFANSTEFTF-HPLFDMGVIVLK 269
               .:.||.:|:|.      ||||.|..|..|:.         |.....||: .|         .
Mouse   317 ---METETQQVAAQ------LLSNLEQSLRTLAQ---------FLPKGPFTYTSP---------S 354

  Fly   270 TSELRVFFVDPEVRNVSGIVNFSGGNMSHFEM-------LHLSDNEEDIRAMKNLESAVFIPEKL 327
            .:||.:...:.:.::|:.:.:    ..:..|:       ..:|:|...:..:.:..:.    |||
Mouse   355 NTELSLMVKEQDNKDVTTVHH----GQTWMELDWAVTAGAKISENGSSVAGILSSPNM----EKL 411

  Fly   328 W----TQLKRKGASYLVFKVYTRDSLFVETEEEIKRRPTSNVISITIPGLNDTKLPGKL--PFFL 386
            .    ..|:::.||.        :..:......:..:..||:.|:.:...|..||...:  .|..
Mouse   412 LGNTPLNLEQRRASL--------EDFYGSPIPSVSLKLLSNINSVFLTNTNTEKLASNVTFKFDF 468

  Fly   387 RNAKANETQFEGGCGYWNYET----WLSDGISTSGGGSLEASSHPVILCHADHLTQFTFLLGVSK 447
            .:.::.|.:.|..|.:|....    |.:||.|.:|.|          .||.:|||.|..|:....
Mouse   469 TSVESIEPRHELICAFWKAHNGNGYWDTDGCSMNGTG----------FCHCNHLTSFAILMAQYH 523

  Fly   448 MQAGLDTNEDDHSLDVITNVGLTLSLLGLLMIFITAAVFKSFRTLASTKILLNLCAALGLQLLFF 512
            :|        |..|::||.|||.|||:.||:..:|..:.|..:: :.|.:.|:||..|.|..:.|
Mouse   524 VQ--------DPRLELITKVGLLLSLICLLLCILTFLLVKPIQS-SRTMVHLHLCICLFLGSIIF 579

  Fly   513 LILSQSHLLEQLEQSESE---RCTLVGAVMQYLLLVVFSWMFIIGFLQYQRYVRVI-GVNHPRHY 573
            |:        .:|....|   ||.||..::.:..|..|.||.:.|...|...|||. |
Mouse   580 LV--------GVENEGGEVGLRCRLVAVMLHFCFLAAFCWMALEGVELYFLVVRVFQG------- 629

  Fly   574 ILMSAVAAWTLPLI---PTLLVVFLEPGSYRPNNSSMDYPILCYPSGYGLSLGVIL--------- 626
               ..::.|...||   ..||:|.:.....:     ||        |||.:....|
Mouse   630 ---QGLSTWQRCLIGYGVPLLIVAISMAVVK-----MD--------GYGHATYCWLDFRKQGFLW 678

  Fly   627 ----PIGLITVANAILVGYISWSVYTALFKRDLIFKQLGLFVLL-------FFLLGITWIFGLCT 680
                |:..|...||.:.....|.:.....:.:...|:|....:|       ..:||.||.|||..
Mouse   679 SFSGPVAFIIFCNAAIFVITVWKLTKKFSEINPNMKKLRKARVLTITSIAQLLVLGCTWGFGLFL 743

  Fly   681 YFDFGRIFAYLFCLTATLQGFVLFLYFIVFNKE-NQRAWLGLCCNSSKKRNQQTIQMPTDSILQG 744
            :.......:|:|.|...|||..|::...:.||: .:..|...|..:..|..:
Mouse   744 FNPHSTWLSYIFTLLNCLQGLFLYVMLCLLNKKVREEYWKWACMVTGSKYTE------------- 795

  Fly   745 LSHSSTNST 753
             .:|||..|
Mouse   796 -FNSSTTGT 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	59/248 (24%)
Adgre5	NP_036055.2	EGF_CA	69..118	CDD:284955	11/38 (29%)
		EGF_CA	165..212	CDD:284955	8/52 (15%)
		EGF_CA	214..248	CDD:284955	5/33 (15%)
		GPS	480..518	CDD:280071	14/47 (30%)
		7tm_2	526..766	CDD:278432	71/271 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	799..818		3/5 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810