DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and Adgrd1

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001074811.1	Gene:	Adgrd1 / 243277	MGIID:	3041203	Length:	903	Species:	Mus musculus

Alignment Length:	763	Identity:	159/763 - (20%)
Similarity:	276/763 - (36%)	Gaps:	212/763 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 RNGNRVWQSL--------DHV--TCRSAPELSSSIN-LLAVKSPPDMISQL-----SNLLTQTQE 168
            |:.:..|::.        .||  |.:|...|...:| .|:...|...:|..     .||:..:::
Mouse   182 RDNSMTWKATFNPPGPYWTHVLFTWKSKEGLKVYVNGTLSTSDPSGKVSHTYGDPHVNLVIGSEQ 246

  Fly   169 KLAAADVFSISEIFDSLVKKPERNAAVVGDLMKICQKVMSTDNETLRVSADANATNALLSNFEDY 233
                           ...|:.|..|.   |...|.::.::.|...:..:| |...:||||:
Mouse   247 ---------------DQTKRYENGAF---DEFIIWERALTPDEIKMYFTA-AIGKHALLSS---- 288

  Fly   234 LDELSPTILKLNTTIFANSTEFTFHPLFDMGVIVLKTSELRVFFVDP-----EVRNVSGIVNFSG 293
                :|..:....|:....   .:||      |:...:|.|..|..|     .::|||  :....
Mouse   289 ----TPPAMPTAHTVIPTD---AYHP------IITNLTEERKRFQRPGTVLRYLQNVS--LRLPN 338

  Fly   294 GNMSHFEMLHLSD----------------NEEDIRAM----------------KNLES------- 319
            .::|....|:|::                :|.:..||                .||:|
Mouse   339 KSLSEETALNLTETFLRTVGEVLLLPSWTHESEDNAMTLGLVDTIDTVMGHISSNLQSREPHVTL 403

  Fly   320 -----------AVFIPEKL--------------------------WTQLKRKGASYLVFKVYTRD 347
                       |..:|..|                          ||.:  .|..|.....|.::
Mouse   404 TGSSSTAEFTVAKVLPPALSAPHYRFPAHGHSYIEIPREALHSQAWTTI--VGLLYHTMHYYLKN 466

  Fly   348 SLFVETE--EEIKRRP-----TSNVISITI--PGLNDTKLPGK--LPFFLRNAKANETQFEGG-- 399
            .....||  |.:..|.     .|::||:.:  |......|.|.  :...||: |..:.|:...
Mouse   467 IHPTSTEIPEAVNCRDCLLSVASHLISLEVSPPPTLSQNLSGSPLITVHLRH-KLTQKQYSDATN 530

  Fly   400 --------CGYWNYETWLSDGISTSGGGSLEASSHPVILCHADHLTQFTFLLGVSKMQAGLDTNE 456
                    |.:.|:.:  .:|:.:|.|.:|...:....:||..|||.|..|:.|..::.   |:.
Mouse   531 ESNRLFLYCAFLNFSS--GEGVWSSQGCALTEGNLTYSVCHCTHLTNFAILMQVVPLKL---THG 590

  Fly   457 DDHSLDVITNVGLTLSLLGLLMIFITAAVFKSFRTLASTK--ILLNLC-AALGLQLLFFLILSQS 518
            ...:|..|:.||.:||:|.|....:|.||..|..|:.:.:  |..||. |.|..|:|..:..|.
Mouse   591 HQVALSSISYVGCSLSVLCLAATLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVLLLISFSM- 654

  Fly   519 HLLEQLEQSESERCTLVGAVMQYLLLVVFSWMFIIGFLQYQRYVRVIGVNHPRHYILMSAVAAWT 583
                   :..:..|.::..::.|..|..|:||.:.|...|...::|.|....:|  |......|.
Mouse   655 -------EPGTVPCQVLAVLLHYFFLTAFAWMLVEGLHLYSMVIKVFGSEDSKH--LYYYGIGWG 710

  Fly   584 LPLIPTLLVVFLEPGSYRPNNSSMDYPILCYPS-GYGLSLGVILPIGLITVANAIL-------VG 640
            .||:..::.:.....||..::|       |:.: |.|.....:.|..|:.|.|.::       :.
Mouse   711 CPLLICIISISSSMDSYGTSDS-------CWLALGSGAIWAFVGPALLVIVVNIVILVAVTRVIS 768

  Fly   641 YISWSVY-----TALFKRDLIFKQLGLFVLLFFLLGITWIFGLCTYFDFGRIFAYLFCLTATLQG 700
            :||...|     .:.||  |..|.:   .:|..:||.:|:||:....|...:|.|:|.:..:|||
Mouse   769 HISTDSYKIHGDPSAFK--LTAKAV---AVLLPILGTSWVFGVLAVSDRALVFQYMFAILNSLQG 828

  Fly   701 FVLFLYFIVFN-------KENQRAWLGLCCNSSKKRNQQTIQMPTDSI 741
            ..:||:..:.|       |...:.|   ...||..|...|....:|::
Mouse   829 LFIFLFHCLLNSEVRAAFKHKTKVW---SLTSSSARTANTKPFSSDTV 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	58/237 (24%)
Adgrd1	NP_001074811.1	Laminin_G_3	<173..273	CDD:290121	19/108 (18%)
		GPS	539..579	CDD:280071	12/41 (29%)
		Stachel. /evidence=ECO:0000250\|UniProtKB:Q6QNK2	575..583		2/7 (29%)
		7tm_4	595..831	CDD:304433	66/257 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	862..903		2/12 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810