DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and Adgrg4

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001349814.1	Gene:	Adgrg4 / 236798	MGIID:	2685213	Length:	3025	Species:	Mus musculus

Alignment Length:	770	Identity:	163/770 - (21%)
Similarity:	312/770 - (40%)	Gaps:	155/770 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LCVDADGQLSHNPYKDCNRGFCKAEDFELEYE----------TDEGKEKRINRVEK--TRVGQKA 99
            |.|.:|    |...:....|.|:|::...:|:          |:..:|:.|....:  ||:...:
Mouse  2272 LLVKSD----HVVVEKLEPGKCEADETPSKYKGTYKWPLTDPTETAQERCIKNENRNATRICSIS 2332

  Fly   100 NLRDLCLNERGIPIRRRCQIRNG--NRVWQSLDHVTC--RSAPELSSSINLLAVKSPPDMISQLS 160
            .....|..|:  |..::|::..|  ::: ..|.::|.  .:|.:::..|..|..:|||
Mouse  2333 IQTGKCQWEK--PRLKQCKLLQGLPDKI-VDLANITISDENADDVAEHILNLVNESPP------- 2387

  Fly   161 NLLTQTQEKLAAADVFSIS--------------EIFDSLVKKPERNAA----VVGDLMKICQKV- 206
              |.:.:.|:..:.|..||              :|.:::.:|...:|:    |..::::|.::|
Mouse  2388 --LDEEETKIIVSKVADISNCDEISINLTQIILQILNTVTEKQSDSASNLPPVSNEILRIIERVG 2450

  Fly   207 --MSTDNETLRVSADANATNALLSNFEDYLDELSPTILKLNTTIFANSTEFTFHPLFDMGVIVLK 269
              |.....|      ||.|.|          :|:..:|:::            |....|...:..
Mouse  2451 HKMEFAGRT------ANLTVA----------KLALAVLRVD------------HKFEGMAFSIQS 2487

  Fly   270 TSELRVFFVDPEVRNVSGIVNFSGGNMSHFEMLHLSDNEEDIRAMKNLESAVFIPEKLWTQLKRK 334
            :.|:    :.|::        |.|                ||...|.|.| :::|:.|..::...
Mouse  2488 SEEV----IAPQI--------FLG----------------DIPLRKALAS-IYLPKSLREKVPLD 2523

  Fly   335 GASYLVFKVYTRDSLFVETEEEIKRRPTSNVISITIPGLNDTKLPGKLPFFLRNAKANETQFEGG 399
            |...::|..:.:.|||  ..:.|.....:.|:|.:|...:...|...:...|::.:.:....:..
Mouse  2524 GLQTILFNFFGQTSLF--KAKTITSELMTYVVSASISNTSIQNLADPVIIILKHIQGDWNYDQVY 2586

  Fly   400 CGYWNYETWLSDGIS--TSGGGSLEASSHPVILCHADHLTQFTFLLGVSKMQAGLDTNEDDHSLD 462
            |.:|:::|  ::|:.  ...|..|:.|:....:|..:|||.|..|:.:|:  :.:|. .::..|.
Mouse  2587 CAFWDFDT--NNGLGGWNPSGCKLKESNINYTICQCNHLTHFGVLMDLSR--STVDA-VNERILV 2646

  Fly   463 VITNVGLTLSLLGLLMIFITAAVFKSFRTLASTKILLNLCAALGLQLLFFLILSQSHLLEQLEQS 527
            :||..|..:|.:.|.:..:|...|...|....:|||:|||.||.:..|.||:.|.....:::
Mouse  2647 IITYTGCGISSIFLGIAMVTYIAFHKLRKDYPSKILINLCTALLMLNLAFLVNSWLTSFQKV--- 2708

  Fly   528 ESERCTLVGAVMQYLLLVVFSWMFIIGFLQYQRYVRVIGVNHPRHYILMSAVAAWTLPLIPTLLV 592
              ..|......:.|.|||..:||.:.....|...|:|.....| :|||...:|.|.:|.|...::
Mouse  2709 --GLCITAAVALHYFLLVSLTWMGLEAVHMYFALVKVFNTYIP-NYILKFCLAGWGIPAITVAII 2770

  Fly   593 VFLEPGSYRPNNSSMDYPILCYPSGYGLSLGVILPIGLITVAN-----AILVGYISWSVYTALFK 652
            :.:....|  ...|...|.......:...:.|:....||.:.|     .:||...|....:...:
Mouse  2771 LSVRKDLY--GTLSPTTPFCWIKDDHIFYISVVAYFCLIFLMNLSMFCTVLVQLTSVKSQSQKTR 2833

  Fly   653 RDLIFKQLGLFVLLFFLLGITWIFGLCTYFDFGRI---FAYLFCLTATLQGFVLFLYFIVFNK-- 712
            :.:|...|...:.|.||||:||.|   .:|.:|.:   |.|||.:..|||||::|:::.|..:
Mouse  2834 KKMILNDLKGTISLTFLLGLTWGF---AFFAWGPVRIFFLYLFAICNTLQGFLIFVFYCVMKESV 2895

  Fly   713 ---------------ENQRAWLGLCCNSSKKRNQQTIQMPTDSILQGLSHSSTNS 752
                           ||...|:.:.....:.:.....::.|.|::...:..|..|
Mouse  2896 REQWHMPLHCRWLRLENFAGWINVRHKQKRLKKNNESKLLTPSLMSTTTFKSIGS 2950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	64/229 (28%)
Adgrg4	NP_001349814.1	LamG	<54..162	CDD:328935
		DnaJ	<276..746	CDD:333066
		GPS	2587..2629	CDD:307782	12/43 (28%)
		7tmB2_GPR112	2642..2903	CDD:320663	72/271 (27%)
		TM helix 1	2644..2669	CDD:320663	7/24 (29%)
		TM helix 2	2679..2701	CDD:320663	11/21 (52%)
		TM helix 3	2712..2739	CDD:320663	7/26 (27%)
		TM helix 4	2754..2770	CDD:320663	4/15 (27%)
		TM helix 5	2793..2816	CDD:320663	4/22 (18%)
		TM helix 6	2838..2863	CDD:320663	10/27 (37%)
		TM helix 7	2867..2892	CDD:320663	11/24 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6570
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	109	1.000	Inparanoid score	I4879
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.060