DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and ADGRL3

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	XP_016863418.1	Gene:	ADGRL3 / 23284	HGNCID:	20974	Length:	1586	Species:	Homo sapiens

Alignment Length:	734	Identity:	172/734 - (23%)
Similarity:	274/734 - (37%)	Gaps:	167/734 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 ETDEGKEKRINRVEKTRVGQKAN----------LRDLCLNERGIPIRRRCQIRNGNRVWQSLDHV 132
            |:.|..|.|.....|||.||.|.          ...|||...||...:...:.|.:..|  ::|:
Human   564 ESCEAVEAREIMWFKTRQGQIAKQPCPAGTIGVSTYLCLAPDGIWDPQGPDLSNCSSPW--VNHI 626

  Fly   133 TCRSAPELSSSINLLAVKSPPDMISQLSNLLTQTQEKLAAADVFSISEIFDSLV----------- 186
            |.:             :||.....:....|..||:..|.|.|:.......|.||
Human   627 TQK-------------LKSGETAANIARELAEQTRNHLNAGDITYSVRAMDQLVGLLDVQLRNLT 678

  Fly   187 --------------KKPERNAAVVGDLMKICQKVMSTDNETLRVSADANATNALLSNFEDYLDEL 237
                          :|.||:...      ..|.::.|.|..|:..| .||...|.::     |:|
Human   679 PGGKDSAARSLNKLQKRERSCRA------YVQAMVETVNNLLQPQA-LNAWRDLTTS-----DQL 731

  Fly   238 SPTILKLNTTIFANSTEFTFHPLFDMGVIVLKTSELRVFFVDPEVRNVSGIVNFSGGNMSHFEML 302
            ....:.|:|.              :....||..:.|:...|.....|:.            .|:.
Human   732 RAATMLLHTV--------------EESAFVLADNLLKTDIVRENTDNIK------------LEVA 770

  Fly   303 HLS--DNEEDIRAMKNL--ESAVFIPEKLWTQLKRKGASYLVFKVYTRDSLFVETEEE-----IK 358
            .||  .|.||::..:|:  .|.:.:......|..|.|...:.|.:|.....::.||..     .:
Human   771 RLSTEGNLEDLKFPENMGHGSTIQLSANTLKQNGRNGEIRVAFVLYNNLGPYLSTENASMKLGTE 835

  Fly   359 RRPTSNVISITIPGL---------NDTKLPGKLPFFLRNAKANETQFEGGCGYWNYETWLSDGIS 414
            ...|::.:.:..|.:         |...|...:.|.:::.|.:|..|...|.:|:|......|..
Human   836 ALSTNHSVIVNSPVITAAINKEFSNKVYLADPVVFTVKHIKQSEENFNPNCSFWSYSKRTMTGYW 900

  Fly   415 TSGGGSLEASSHPVILCHADHLTQFTFLLGVSKMQAGLDTNEDD--HS--LDVITNVGLTLSLLG 475
            ::.|..|..::.....|..:|||.|..|:      |.::....|  |.  |||||.||:.|||:.
Human   901 STQGCRLLTTNKTHTTCSCNHLTNFAVLM------AHVEVKHSDAVHDLLLDVITWVGILLSLVC 959

  Fly   476 LLMIFITAAVFKSFRTLASTKILLNLCAALGLQLLFFLILSQSHLLEQLEQSESERCTLVGAVMQ 540
            ||:...|...|:..::..:| |..|||.:|.:..|.|||     .:.:.:|..:  |.:..|::.
Human   960 LLICIFTFCFFRGLQSDRNT-IHKNLCISLFVAELLFLI-----GINRTDQPIA--CAVFAALLH 1016

  Fly   541 YLLLVVFSWMFIIGFLQYQRYVRVIGVNHPRH-YILMSAVAAWTLPLIPTLLVVFLEPGSYRPNN 604
            :..|..|:|||:.|...|...|.|....|.|. |..:....      :|.|:|.......||...
Human  1017 FFFLAAFTWMFLEGVQLYIMLVEVFESEHSRRKYFYLVGYG------MPALIVAVSAAVDYRSYG 1075

  Fly   605 SSMDYPILCYPSGYGLSL------GVILPIGLITVANAILVGYISWSVY--TALFK--------- 652
            :..    :|:     |.|      ..|.|..||.:.|.|.:|...:.::  ||:.|
Human  1076 TDK----VCW-----LRLDTYFIWSFIGPATLIIMLNVIFLGIALYKMFHHTAILKPESGCLDNI 1131

  Fly   653 -----RDLIFKQLGLFVLLFFLLGITWIFGLCTYFDFGRIFAYLFCLTATLQGFVLFLYFIVFNK 712
                 |..|...:...:.|..|||:||.|||....:...|.||||.:..:|||..:|::..|..|
Human  1132 NYEDNRPFIKSWVIGAIALLCLLGLTWAFGLMYINESTVIMAYLFTIFNSLQGMFIFIFHCVLQK 1196

  Fly   713 ENQRAWLGLC----CNSSK 727
            :.::.: |.|    |.|.|
Human  1197 KVRKEY-GKCLRTHCCSGK 1214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	64/244 (26%)
ADGRL3	XP_016863418.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810