DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and ADGRL2

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001352934.1	Gene:	ADGRL2 / 23266	HGNCID:	18582	Length:	1469	Species:	Homo sapiens

Alignment Length:	744	Identity:	167/744 - (22%)
Similarity:	269/744 - (36%)	Gaps:	202/744 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 ERGIPIRRRCQIRNGNR------------VWQSLDHVTCRSAPELSSS----INLLA--VKSPPD 154
            :||:.:.|.|.  .|.|            .|..       ..|:||:.    :|.||  ::|..:
Human   487 QRGMMVERPCP--KGTRGTASYLCMISTGTWNP-------KGPDLSNCTSHWVNQLAQKIRSGEN 542

  Fly   155 MISQLSNLLTQTQEKLAAADVFSISEIFDSLV----------KKPERNAAVVGDLMKICQKVMST 209
            ..|..:.|...|:..:.|.||.|...:.:.||          |..|:::|  |......||...|
Human   543 AASLANELAKHTKGPVFAGDVSSSVRLMEQLVDILDAQLQELKPSEKDSA--GRSYNKLQKREKT 605

  Fly   210 DNETLRVSADANATNALLSNFEDYLDE-LSPTILK----LNTTIFANSTEFTFHPLFDMGVIVLK 269
                         ..|.|....|.:|. |.|..|:    :|::..|::.......| :.|..||.
Human   606 -------------CRAYLKAIVDTVDNLLRPEALESWKHMNSSEQAHTATMLLDTL-EEGAFVLA 656

  Fly   270 TSELRVFFVDPEVRNVSGIVNFSGGNMSHFEMLHLSDNEEDIR---AMKNLESAVFIPEKLWTQL 331
            .:.|....|.....|:          :....:|......:|.:   .:|...|::.:......|.
Human   657 DNLLEPTRVSMPTENI----------VLEVAVLSTEGQIQDFKFPLGIKGAGSSIQLSANTVKQN 711

  Fly   332 KRKGASYLVFKVYTRDSLFVETE--------EEIKRRPT----SNVISITIPG------LNDTKL 378
            .|.|.:.|||.:|.....|:.||        :.|.|..|    |:|||::|..      |.|..|
Human   712 SRNGLAKLVFIIYRSLGQFLSTENATIKLGADFIGRNSTIAVNSHVISVSINKESSRVYLTDPVL 776

  Fly   379 PGKLPFFLRNAKANETQFEGGCGYWNYETWLSDGISTSGGGSLEASSHPVILCHADHLTQFTFLL 443
                 |.|.:... :..|...|.:|||......|..::.|..|..::.....|...|||.|..|:
Human   777 -----FTLPHIDP-DNYFNANCSFWNYSERTMMGYWSTQGCKLVDTNKTRTTCACSHLTNFAILM 835

  Fly   444 ---------GVSKMQAGLDTNEDDHSLDVITNVGLTLSLLGLLMIFITAAVFKSFRTLASTKILL 499
                     ||.::           .|.|||.||:.:||:.|.:...|...|:..::..:| |..
Human   836 AHREIAYKDGVHEL-----------LLTVITWVGIVISLVCLAICIFTFCFFRGLQSDRNT-IHK 888

  Fly   500 NLCAALGLQLLFFLILSQSHLLEQLEQSE-SERCTLVGAVMQYLLLVVFSWMFIIGFLQYQRYVR 563
            |||..|.:....|||        .::::: :..|.:...::.:..|..|:||.:.|...|...|.
Human   889 NLCINLFIAEFIFLI--------GIDKTKYAIACPIFAGLLHFFFLAAFAWMCLEGVQLYLMLVE 945

  Fly   564 VIGVNHPR--HYILMSAVAAWTLPLIPTLLVVFLEPGSYRPNNSSMDYPILCYPSGYGLSLGVIL 626
            |....:.|  :|.    ||.:..|  .|::.|          ::::||      ..||......|
Human   946 VFESEYSRKKYYY----VAGYLFP--ATVVGV----------SAAIDY------KSYGTEKACWL 988

  Fly   627 ------------PIGLITVANAILVGYISWSVYT--ALFKRDLIFKQ------------LGLFVL 665
                        |:..|.:.|.|.:      |.|  .:.|.....|.            ||.|.|
Human   989 HVDNYFIWSFIGPVTFIILLNIIFL------VITLCKMVKHSNTLKPDSSRLENIKSWVLGAFAL 1047

  Fly   666 LFFLLGITWIFGLCTYFDFGRIFAYLFCLTATLQGFVLFLYFIVFNKENQRAW-----LGLCCNS 725
            | .|||:||.|||....:...:.||||.:....||..:|::.....|:.::.:     ...||..
Human  1048 L-CLLGLTWSFGLLFINEETIVMAYLFTIFNAFQGVFIFIFHCALQKKVRKEYGKCFRHSYCCGG 1111

  Fly   726 SKKRNQQTIQMPTDSILQGLSHSSTNSTS 754
                      :||:|     .|||..:::
Human  1112 ----------LPTES-----PHSSVKAST 1125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	59/250 (24%)
ADGRL2	NP_001352934.1	Gal_Lectin	49..129	CDD:307994
		OLF	142..398	CDD:321983
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	426..460
		HormR	469..533	CDD:214468	11/54 (20%)
		GAIN	542..764	CDD:318649	54/247 (22%)
		GPS	788..840	CDD:197639	14/51 (27%)
		7tmB2_Latrophilin-2	848..1105	CDD:320672	70/305 (23%)
		TM helix 1	850..875	CDD:320672	10/24 (42%)
		TM helix 2	884..906	CDD:320672	9/30 (30%)
		TM helix 3	915..942	CDD:320672	6/26 (23%)
		TM helix 4	954..974	CDD:320672	6/35 (17%)
		TM helix 5	991..1020	CDD:320672	6/34 (18%)
		TM helix 6	1036..1063	CDD:320672	13/27 (48%)
		TM helix 7	1067..1092	CDD:320672	7/24 (29%)
		Latrophilin	1104..1469	CDD:308136	8/37 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1368..1410
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810