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Protein Alignment CG15556 and ADGRL1

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	XP_016881964.1	Gene:	ADGRL1 / 22859	HGNCID:	20973	Length:	1506	Species:	Homo sapiens

Alignment Length:	756	Identity:	159/756 - (21%)
Similarity:	260/756 - (34%)	Gaps:	222/756 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 ERGIPIRRRCQIRNGNRVWQSLDHVTCRSA--------PELSSS----INLLA--VKSPPDMISQ 158
            ::|:.:.|.|.  .|.|   .:....|..|        |:||:.    :|.:|  :||..:..:.
Human   502 QQGMLVERPCP--KGTR---GIASFQCLPALGLWNPRGPDLSNCTSPWVNQVAQKIKSGENAANI 561

  Fly   159 LSNLLTQTQEKLAAADVFSISEIFDSLVK---------KP-ERNAA------------VVGDLMK 201
            .|.|...|:..:.|.||.|..::.:.|:.         :| ||.:|            ...|.:|
Human   562 ASELARHTRGSIYAGDVSSSVKLMEQLLDILDAQLQALRPIERESAGKNYNKMHKRERTCKDYIK 626

  Fly   202 ICQKVMSTDN----ETLRVSADANATNAL--LSNFEDYLDELSPTILKLNTTIFANSTEFTFHPL 260
            ..  |.:.||    |.|....|.|||..:  .:...|.|:|        ...:.|::.......|
Human   627 AV--VETVDNLLRPEALESWKDMNATEQVHTATMLLDVLEE--------GAFLLADNVREPARFL 681

  Fly   261 FDMGVIVLKTSELRVFFVDPEVRNVSGIVNFSGGNMSHFEMLHLSDNEEDIRAMKNLESAVFIPE 325
            .....:||:.:          |.|..|.|.         |::.  ..||..|     ::::.:..
Human   682 AAKENVVLEVT----------VLNTEGQVQ---------ELVF--PQEEYPR-----KNSIQLSA 720

  Fly   326 KLWTQLKRKGASYLVFKVYTRDSLFVETE--------------------------------EEIK 358
            |...|..|.|...:||.:|....||:.||                                :|..
Human   721 KTIKQNSRNGVVKVVFILYNNLGLFLSTENATVKLAGEAGPGGPGGASLVVNSQVIAASINKESS 785

  Fly   359 RRPTSNVISITIPGLNDTKLPGKLPFFLRNAKANETQFEGGCGYWNYETWLSDGISTSGGGSLEA 423
            |....:.:..|:..|.|                 :..|...|.:|||......|..::.|..|..
Human   786 RVFLMDPVIFTVAHLED-----------------KNHFNANCSFWNYSERSMLGYWSTQGCRLVE 833

  Fly   424 SSHPVILCHADHLTQFTFLLGVSKMQAGLDTNEDDHSLDVITNVGLTLSLLGLLMIFITAAVFKS 488
            |:.....|...|||.|..|:...::..|   ..::..|.|||.||:.:||:.|.:...|....:.
Human   834 SNKTHTTCACSHLTNFAVLMAHREIYQG---RINELLLSVITWVGIVISLVCLAICISTFCFLRG 895

  Fly   489 FRTLASTKILLNLCAALGLQLLFFLILSQSHLLEQLEQSESE-RCTLVGAVMQYLLLVVFSWMFI 552
            .:|..:| |..|||..|.|..|.||:        .:::::.| .|.:...::.|..|..|||:.:
Human   896 LQTDRNT-IHKNLCINLFLAELLFLV--------GIDKTQYEIACPIFAGLLHYFFLAAFSWLCL 951

  Fly   553 IGFLQYQRYVRVIGVNHPR--HYILMSAVAAWTLPLIPTLLVVFLEPGSYRPNNSSM----DYPI 611
            .|...|...|.|....:.|  :|.|    ..:..|.:...:...::..||....:..    :|.|
Human   952 EGVHLYLLLVEVFESEYSRTKYYYL----GGYCFPALVVGIAAAIDYRSYGTEKACWLRVDNYFI 1012

  Fly   612 LCYPSGYGLSLGVILPIGLITVANAI----------------------LVGYISWSVYTALFKRD 654
            ..:          |.|:..:.|.|.:                      |....||:
Human  1013 WSF----------IGPVSFVIVVNLVFLMVTLHKMIRSSSVLKPDSSRLDNIKSWA--------- 1058

  Fly   655 LIFKQLGLFVLLFFLLGITWIFGLCTYFDFGRIFAYLFCLTATLQGFVLFLYFIVFNKENQRAWL 719
                 ||...|| ||||:||.|||........:.||||......||..:|::.....|:..:.:.
Human  1059 -----LGAIALL-FLLGLTWAFGLLFINKESVVMAYLFTTFNAFQGVFIFVFHCALQKKVHKEYS 1117

  Fly   720 -----GLCCNSSKKRNQQTIQMPTDSILQGLSHSSTNSTSI 755
                 ..||          |:.|     .|.:|.|..::::
Human  1118 KCLRHSYCC----------IRSP-----PGGTHGSLKTSAM 1143

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.