DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and ADGRF4

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001334784.1	Gene:	ADGRF4 / 221393	HGNCID:	19011	Length:	695	Species:	Homo sapiens

Alignment Length:	760	Identity:	163/760 - (21%)
Similarity:	294/760 - (38%)	Gaps:	184/760 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 KAEDFELEYETDEGKEKRINRVEKTRVG---QKANLRDLCLNERGIPIRRRCQIRNGNRVWQ-SL 129
            ||.|   :.::.|||.| ..|:::...|   ..:|....|..:....|...|    ..:.|| |.
Human    31 KAGD---KLQSPEGKPK-TGRIQEKCEGPCISSSNCSQPCAKDFHGEIGFTC----NQKKWQKSA 87

  Fly   130 DHVTCRSAPEL---SSSINLLAVKSPPDMISQLSNLLTQTQEKLAAA-------DVFSISEIFDS 184
            :..|..|..:|   |:..:.|:|.:|...:..|.....:|.|.:|..       |...|::
Human    88 ETCTSLSVEKLFKDSTGASRLSVAAPSIPLHILDFRAPETIESVAQGIRKNCPFDYACITD---- 148

  Fly   185 LVKKPER---NAAVVGDLMKICQKVMSTDNETL-RVSADANATN-----ALLSNFEDYLDELSPT 240
            :||..|.   |.|.:.:|:|.....:| ||.|. ::.:.:...|     |.:||:....::.:.:
Human   149 MVKSSETTSGNIAFIVELLKNISTDLS-DNVTREKMKSYSEVANHILDTAAISNWAFIPNKNASS 212

  Fly   241 ILKLNTTIFA------NSTEFTFHPLFDMGVIVLKTSELRVFFVDPEVRNVSGIVNFSGGNMSHF 299
            .|..:..:||      |::|...:.||         .:.:.|.::......|  :|||
Human   213 DLLQSVNLFARQLHIHNNSENIVNELF---------IQTKGFHINHNTSEKS--LNFS------- 259

  Fly   300 EMLHLSDNEEDIRAMKNLESAVFIP----EKLWTQLKRKGASYLVFKVYTRDSLFVETEEE---I 357
              :.:::..|||..|      |.||    .|||....:  |..:.|.  |..::..|...:   :
Human   260 --MSMNNTTEDILGM------VQIPRQELRKLWPNASQ--AISIAFP--TLGAILREAHLQNVSL 312

  Fly   358 KRRPTSNVISITIP-----------GLNDTKLPGKLPFFLRNAKANETQFEGGCGYWNYE--TWL 409
            .|:....|:|:.:|           .:|.|          |||:|.       |..|:.:  .|.
Human   313 PRQVNGLVLSVVLPERLQEIILTFEKINKT----------RNARAQ-------CVGWHSKKRRWD 360

  Fly   410 SDGISTSGGGSLEASSHPVILCHADH---LTQFTFLLGVSKMQAGLDTNEDDHSLDVITNVGLTL 471
            ......    .|:..:.  :.|..::   :..|:.|:....|        .|..||.||.:||::
Human   361 EKACQM----MLDIRNE--VKCRCNYTSVVMSFSILMSSKSM--------TDKVLDYITCIGLSV 411

  Fly   472 SLLGLLMIFITAAVFKSFRTLASTKI-------LLNLCAALGLQLLFFLILSQSHLLEQLEQSES 529
            |:|.|::..|..|...|  .:..|:|       ::|:..:|....::|:|.|..::..|    :.
Human   412 SILSLVLCLIIEATVWS--RVVVTEISYMRHVCIVNIAVSLLTANVWFIIGSHFNIKAQ----DY 470

  Fly   530 ERCTLVGAVMQYLLLVVFSWM------FIIGFLQ-YQRYVR----VIGVNHPRHYILMSAVAAWT 583
            ..|..|.....:..|.:|.||      .|.|.|. ::|.::    |||.           ...:.
Human   471 NMCVAVTFFSHFFYLSLFFWMLFKALLIIYGILVIFRRMMKSRMMVIGF-----------AIGYG 524

  Fly   584 LPLI---PTLLVVFLEPGSYRPNNSSMDYPILCYPSGYGLSLGVILPIGLITVANAILVGYISWS 645
            .|||   .|:.:...|.|..||....:::........:.:...||:.:.||.|. .:.|.....|
Human   525 CPLIIAVTTVAITEPEKGYMRPEACWLNWDNTKALLAFAIPAFVIVAVNLIVVL-VVAVNTQRPS 588

  Fly   646 VYTALFKRDLIFKQLGLFV-LLFFLLGITWIFGLCTYFDFGRI-FAYLFCLTATLQGFVLFLYFI 708
            :.::..:..:|..::...| :|..|||:||.||:.|..:...: |..:|.|....|||.:.|:..
Human   589 IGSSKSQDVVIIMRISKNVAILTPLLGLTWGFGIATLIEGTSLTFHIIFALLNAFQGFFILLFGT 653

  Fly   709 VFNKENQRAWLGLCCNSSKKRNQQTIQMPTDSILQGLSHSSTNST 753
            :.:              .|.|:...::|   |.|:|.|.::.|::
Human   654 IMD--------------HKIRDALRMRM---SSLKGKSRAAENAS 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	56/244 (23%)
ADGRF4	NP_001334784.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..695		2/8 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810