DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and ADGRG5

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001291305.1	Gene:	ADGRG5 / 221188	HGNCID:	19010	Length:	528	Species:	Homo sapiens

Alignment Length:	459	Identity:	111/459 - (24%)
Similarity:	181/459 - (39%)	Gaps:	117/459 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   343 VYTRDSLFVETEEEIKRRPTSNVISITIPG-------LNDTKLPGKLPFFLRNAKANETQFEG-- 398
            :|..::.|.:.|.      .|::::..:.|       :|:.:.|..:.|:      :....||
Human   134 IYFSNTHFFKDEN------NSSLLNNYVLGAQLSHGHVNNLRDPVNISFW------HNQSLEGYT 186

  Fly   399 -GCGYWN-------YETWLSDGISTSGGGSLEASSHPVILCHADHLTQFTFLLGVSKMQAGLDTN 455
             .|.:|.       :..|..:|..|      |..||..:||..:|||.|..|:   ::...|...
Human   187 LTCVFWKEGARKQPWGGWSPEGCRT------EQPSHSQVLCRCNHLTYFAVLM---QLSPALVPA 242

  Fly   456 EDDHSLDVITNVGLTLSLLGLLMIFITAAVFKSFRTLAS--TKILLNLCAALGLQLLFFLILSQS 518
            |....|..|:.||.::|::..|   ||..:...||..:.  |:|.:||.|::.|..:.|| ||.:
Human   243 ELLAPLTYISLVGCSISIVASL---ITVLLHFHFRKQSDSLTRIHMNLHASVLLLNIAFL-LSPA 303

  Fly   519 HLLEQLEQSESERCTLVGAVMQYLLLVVFSWMFIIGFLQYQRYVRVIGVNHPRHYILMSAVAAWT 583
            ..:..:..|   .||.:.|.:.|.||...:||.|.||..|....||..: :.|.|:....|..|.
Human   304 FAMSPVPGS---ACTALAAALHYALLSCLTWMAIEGFNLYLLLGRVYNI-YIRRYVFKLGVLGWG 364

  Fly   584 LPLIPTLLVVFLEPGSYRP----------NNSSMDYPILCY----------PSGYGLSLGVILPI 628
            .|.:..||.:.::...|.|          |.:......:|:          ..|||
Human   365 APALLVLLSLSVKSSVYGPCTIPVFDSWENGTGFQNMSICWVRSPVVHSVLVMGYG--------- 420

  Fly   629 GLITVANAILVGYISWSVYTALFKRDL--------IFKQLGLFVLLFFLLGITWIFGLCTYFDFG 685
            ||.::.|.:::.:..|::.....:.|.        ....|||.|    |||.||..   .:|.||
Human   421 GLTSLFNLVVLAWALWTLRRLRERADAPSVRACHDTVTVLGLTV----LLGTTWAL---AFFSFG 478

  Fly   686 RIF----AYLFCLTATLQGFVLFLYFIVFNKENQRAWLGLCCNSSKKRNQQTIQMPTDSILQGLS 746
             :|    .:||.:..:|.||.|||:|.     :||      |.|..:...|         ::..|
Human   479 -VFLLPQLFLFTILNSLYGFFLFLWFC-----SQR------CRSEAEAKAQ---------IEAFS 522

  Fly   747 HSST 750
            .|.|
Human   523 SSQT 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	66/255 (26%)
ADGRG5	NP_001291305.1	GPS	187..232	CDD:307782	14/50 (28%)
		7tmB2_GPR114	245..518	CDD:320559	81/317 (26%)
		TM helix 1	247..272	CDD:320559	8/27 (30%)
		TM helix 2	281..303	CDD:320559	10/22 (45%)
		TM helix 3	315..342	CDD:320559	11/26 (42%)
		TM helix 4	355..375	CDD:320559	5/19 (26%)
		TM helix 5	409..438	CDD:320559	7/37 (19%)
		TM helix 6	451..478	CDD:320559	10/33 (30%)
		TM helix 7	482..507	CDD:320559	9/29 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6566
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910