DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and Adgrg6

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	XP_006512741.1	Gene:	Adgrg6 / 215798	MGIID:	1916151	Length:	1258	Species:	Mus musculus

Alignment Length:	738	Identity:	179/738 - (24%)
Similarity:	294/738 - (39%)	Gaps:	152/738 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 RINRVEKTRVGQKANLRD----------------LCLNERGIPIRRRCQIRNGNRVWQSLDHVTC 134
            |:..|:..::|..:.|.|                .|.|:.|..:.|.|.....:..|..:|...|
Mouse   524 RLCEVDVNQLGMCSALEDPDGFSWPATLPSVYKQPCPNKPGFFMTRACLSNGTSTFWGPVDTSNC 588

  Fly   135 -RSAPELSSSINLLAVKSPPDMISQLSNLLTQT--QEKLAAADVFSISEIFDSLVKKPERNAAVV 196
             |.:.|:::.|                  |.||  .:.|.:|::.||.|....:|.|.|.....:
Mouse   589 SRQSNEVANEI------------------LNQTGDGQNLTSANINSIVEKVKRIVNKEENIDITL 635

  Fly   197 GD-LMKICQKVM-STDNETLRVSADANATNALLSNFEDYLDELSPTILKLNTTIFANSTEFTFHP 259
            |. ||.|...:: |:|::.|..|.:|..|          :|||:..| .||:|...|
Mouse   636 GSTLMNIFSNILSSSDSDLLESSTEALKT----------IDELAFKI-DLNSTPHVN-------- 681

  Fly   260 LFDMGVIVLKTSELRVFFVDPEVRNVSGIV-------NFSGG----NMSHFEMLHLSDNEEDIRA 313
                    ::|..|.:        .||.::       |||.|    |.|:|:| ...:.:.|..|
Mouse   682 --------IETQNLAL--------GVSSLIPGTNAPSNFSIGLPSNNESYFQM-DFGNGQTDPLA 729

  Fly   314 MKNLESAVFIPEKLWTQLKRKGASYLV----FKVYTRDSLFVETEEEIKRRPTSNVISITIPGLN 374
                  :|.:|..|...|..:. |.||    |..:.:..||.:...: ::...|.|::.:|..:.
Mouse   730 ------SVILPPNLLENLSPED-SVLVRRAQFTFFNKTGLFQDVGSQ-RKVLVSYVMACSIGNIT 786

  Fly   375 DTKLPGKLPFFLRNAKANETQFEGGCGYWNYETWLS-DGISTSG---GGSLEASSHPVILCHADH 435
            ...|...:...:::.:..|.. ...|.:|:.....| .|.:|||   ...|:|..   .:|...|
Mouse   787 IQNLKDPVQIKIKHTRTQEVH-HPICAFWDMNKNKSFGGWNTSGCVAHSDLDAGE---TICLCSH 847

  Fly   436 LTQFTFLLGVSKMQAGLDTNEDDHSLDVITNVGLTLSLLGLLMIFITAAVFKSFRTLASTKILLN 500
            .|.|..|:.:.:..:.:| ..:...|..||.:|..:|.:......:|...|:..|....:|||:|
Mouse   848 FTHFGVLMDLPRSASQID-GRNTKVLTFITYIGCGISAIFSAATLLTYVAFEKLRRDYPSKILMN 911

  Fly   501 LCAALGLQLLFFLILSQSHLLEQLEQS--ESERCTLVGAVMQYLLLVVFSWMFIIGFLQYQRYVR 563
            |.:||       |.|:...||:....|  .:..||.|.|::.:.||..|:||.:.....|...|:
Mouse   912 LSSAL-------LFLNLIFLLDGWVTSFGVAGLCTAVAALLHFFLLATFTWMGLEAIHMYIALVK 969

  Fly   564 VIGVNHPRHYILMSAVAAWTLP--LIPTLLVVFLEPGSYRPNNSSMDY---------PILCYPS- 616
            |.. .:...|||...:..|.||  ::..:||...:...|...:...|.         |::.|.|
Mouse   970 VFN-TYIHRYILKFCIIGWGLPALVVSIILVSRRQNEVYGKESYGKDQDDEFCWIQDPVVFYVSC 1033

  Fly   617 -GYGLSLGVI--LPIGLITVANAILVGYISWSVYTALFKRDLIFKQLGLFVLLFFLLGITWIFGL 678
             ||   .||:  |.:.:..|....:.|.........|  |:.:.:.|...|.|.||||:||.|
Mouse  1034 AGY---FGVMFFLNVAMFIVVMVQICGRNGKRSNRTL--REEVLRNLRSVVSLTFLLGMTWGF-- 1091

  Fly   679 CTYFDFGRI---FAYLFCLTATLQGFVLFLYFIVFNKENQRAW-LGLCC-------NSS-KKRNQ 731
             .:|.:|.:   |.|||.:..:|||..:|::.....:..|:.| ..|||       ||. .|...
Mouse  1092 -AFFAWGPLNIPFMYLFSIFNSLQGLFIFIFHCAMKENVQKQWRRHLCCGRFRLADNSDWSKTAT 1155

  Fly   732 QTIQMPTDSILQGLSHSSTNSTS 754
            ..|:..:|::.:.||.||..|.|
Mouse  1156 NIIKKSSDNLGKSLSSSSIGSNS 1178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	68/241 (28%)
Adgrg6	XP_006512741.1	CUB	48..156	CDD:238001
		LamG	188..347	CDD:389952
		HRM	543..588	CDD:382965	7/44 (16%)
		GPS	809..854	CDD:366827	13/47 (28%)
		7tm_GPCRs	869..1137	CDD:391938	76/283 (27%)
		TM helix 1	871..896	CDD:341315	6/24 (25%)
		TM helix 2	906..928	CDD:341315	11/28 (39%)
		TM helix 3	939..966	CDD:341315	9/26 (35%)
		TM helix 4	981..997	CDD:341315	3/15 (20%)
		TM helix 5	1026..1049	CDD:341315	8/25 (32%)
		TM helix 6	1072..1097	CDD:341315	11/27 (41%)
		TM helix 7	1101..1126	CDD:341315	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6570
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	109	1.000	Inparanoid score	I4879
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.960