DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and ADGRE1

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	XP_011526096.1	Gene:	ADGRE1 / 2015	HGNCID:	3336	Length:	978	Species:	Homo sapiens

Alignment Length:	780	Identity:	167/780 - (21%)
Similarity:	308/780 - (39%)	Gaps:	186/780 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 NVARCLDYCHLKNLRFLLCVDADGQLSHNPYKDCNRGFCKAEDFELEYETDEGKEKR-IN--RVE 91
            ::..|.:.|.:.:    .|.:..|..    :..|:.||..:.. :|.: ||:|.|.| |:  |.:
Human   313 DIDECTEMCPINS----TCTNTPGSY----FCTCHPGFAPSNG-QLNF-TDQGVECRDIDECRQD 367

  Fly    92 KTRVGQKANLRDLCLNERGIPIRRRCQIRNGNRVWQSLDHVTC------RSAPELSS-----SIN 145
            .:..|..:    :|.|                    :|...:|      ...||.|.     |..
Human   368 PSTCGPNS----ICTN--------------------ALGSYSCGCIAGFHPNPEGSQKDGNFSCQ 408

  Fly   146 LLAVKSPPDMISQLSNLLTQTQEKLAAADVF-----SISEIFDSLVKKPERNAAVVGDLMKICQK 205
            .:..|...|:|.. :..:.|.||..|....:     .|:.||..              |.|:|
Human   409 RVLFKCKEDVIPD-NKQIQQCQEGTAVKPAYVSFCAQINNIFSV--------------LDKVC-- 456

  Fly   206 VMSTDNETLRVSADANATNALLSNFEDYLDELSPTILKLNTTIFANSTEFTFHPLFDMGVIVLKT 270
                :|:|..||. .|.|.:.:           |.:.:::|.     |:||......:..:.|::
Human   457 ----ENKTTVVSL-KNTTESFV-----------PVLKQISTW-----TKFTKEETSSLATVFLES 500

  Fly   271 SE---LRVFF-----VDPEVRN-----VSGIVN--FSGGNMSHFEMLHLSDNEEDIRAMKNLESA 320
            .|   |..|:     :.|.||.     .|.::|  .|..|:: .:::...|.      ||...|.
Human   501 VESMTLASFWKPSANITPAVRTEYLDIESKVINKECSEENVT-LDLVAKGDK------MKIGCST 558

  Fly   321 VFIPEKLWTQLKRKGASYLVF--------KVYTRDSLFVETEEEIKRRPTSNVISITIPGLNDTK 377
            :...|...|    .|.:::.|        :.:.:|.....|..|||.:..|.|:...:.|.....
Human   559 IEESESTET----TGVAFVSFVGMESVLNERFFKDHQAPLTTSEIKLKMNSRVVGGIMTGEKKDG 619

  Fly   378 LPGKLPFFLRNAKANETQFEGG-CGYWNYETWLSDGISTSGGGSLEASSHPVILCHADHLTQFTF 441
            ....:.:.|.|.:..: :||.. |..|:  |.:..|..||.|..:..:|....:|..:.:.....
Human   620 FSDPIIYTLENIQPKQ-KFERPICVSWS--TDVKGGRWTSFGCVILEASETYTICSCNQMANLAV 681

  Fly   442 LLGVSKMQAGLDTNEDDHSLDVITNVGLTLSLLGLLMIFITAAVFKSFRTLASTKILLNLCAALG 506
            ::...::..       |.||.:|::||:.:||:.|::...|..:.:|.|. .:|.:.|:||..
Human   682 IMASGELTM-------DFSLYIISHVGIIISLVCLVLAIATFLLCRSIRN-HNTYLHLHLCVC-- 736

  Fly   507 LQLLFFLILSQSHLLEQLEQSESER-CTLVGAVMQYLLLVVFSWMF---IIGFLQYQRYVRVIGV 567
                  |:|:::..|..:.:::::. |.::...:.||.|..|.||.   :|.||.. |.::|:..
Human   737 ------LLLAKTLFLAGIHKTDNKMGCAIIAGFLHYLFLACFFWMLVEAVILFLMV-RNLKVVNY 794

  Fly   568 NHPRHYILMSAVA-AWTLPLIPTLLVVFLEPGSYRPNNSSMDYPILCY---PSGYGLS-LGVILP 627
            ...|:..::...| .:.||::..::...::|..|..:|.       |:   .:|:..| ||   |
Human   795 FSSRNIKMLHICAFGYGLPMLVVVISASVQPQGYGMHNR-------CWLNTETGFIWSFLG---P 849

  Fly   628 IGLITVANAILVGYISW-----------SVYTALFKRDLIFKQLGLFVLLFFLLGITWIFGLCTY 681
            :..:.|.|::|:.:..|           .|.|....|.|.||   .|..| |:||.:|:.|:...
Human   850 VCTVIVINSLLLTWTLWILRQRLSSVNAEVSTLKDTRLLTFK---AFAQL-FILGCSWVLGIFQI 910

  Fly   682 FDFGRIFAYLFCLTATLQGFVLFLYFIVFN---KENQRAWL-GLCCNSSKKRNQQTI--QMPTDS 740
            .....:.||||.:..:|||..:||...:.|   :|..:.|: |....||:.:..:.:  .||:.|
Human   911 GPVAGVMAYLFTIINSLQGAFIFLIHCLLNGQVREEYKRWITGKTKPSSQSQTSRILLSSMPSAS 975

Fly 741 740
Human 976 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	59/241 (24%)
ADGRE1	XP_011526096.1	EGF_CA	33..62	CDD:238011
		EGF_CA	80..114	CDD:214542
		EGF_CA	132..171	CDD:214542
		EGF_CA	172..206	CDD:214542
		EGF_CA	224..260	CDD:214542
		EGF_CA	264..297	CDD:214542
		EGF_CA	313..>342	CDD:214542	5/36 (14%)
		EGF_CA	360..400	CDD:284955	9/63 (14%)
		GPS	638..687	CDD:197639	10/50 (20%)
		7tm_2	691..932	CDD:278432	68/264 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810