DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and lat-1

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001366731.1	Gene:	lat-1 / 174419	WormBaseID:	WBGene00002251	Length:	1014	Species:	Caenorhabditis elegans

Alignment Length:	792	Identity:	162/792 - (20%)
Similarity:	285/792 - (35%)	Gaps:	225/792 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 ETDEGKEKRINRVEKTRVGQKANLRDLCLNERGIPIRRRCQIRNGNRVWQSLDHVTCRSA--PEL 140
            |.:|.::..:|......|.:|.::.....|.||:.             ||:....|..||  ||.
Worm   159 EEEEAQKDALNSDVIKPVKKKEDVFCSATNRRGVN-------------WQNTKSGTTSSAPCPEG 210

  Fly   141 SSSINLLAVKSPPDMISQL-------SNLLTQTQEKL----AAADVFSISEIFDSLVKKPERNAA 194
            ||...|.|.......:::.       ||.::.....|    ::.||..:.|...:|..: .|...
Worm   211 SSGKQLWACTEEGQWLTEFPNSAGCESNWISSRNSVLSGVISSEDVSGLPEFLRNLGSE-TRRPM 274

  Fly   195 VVGDLMKICQKVMSTDNETLRVSADANATNALLSNFEDYLDELSPTILKLNTTIFANSTEFTFHP 259
            |.|||.|:...:..|.|                                   .|...|..:...|
Worm   275 VGGDLPKVLHLLEKTVN-----------------------------------VIAEESWAYQHLP 304

  Fly   260 LFDMGVI-----------------VLKTSELRVFFV----DPEVRNVSGIVNFSGGN-------- 295
            |.:.|.:                 |.|..|....|:    ...|.:..|::..:..|
Worm   305 LSNKGAVEVMNYMLRNQEIWGSWDVTKRKEFASRFILAAEKAMVASAKGMMTSAESNVIVQPAIT 369

  Fly   296 --MSHFEMLHLSDNEEDIRAMKNLESAVFIPEKLW-------TQLKRKGASYLVFKVYTRDS-LF 350
              :||  .:.:|....|.        .:|....||       ..:.|..    :.|:...:: :|
Worm   370 VEISH--KIKMSSQPTDY--------ILFPSAALWNGQNVDNVNIPRDA----ILKINKDETQVF 420

  Fly   351 VETEEEIKRRPTSNVISITIPGLNDTKL----------------------------PGKLPFFLR 387
            ..:.:.:..:.|.:.:::.|.|.:.|::                            |.::.|:.:
Worm   421 FSSFDNLGAQMTPSDVTVAIAGTDQTEVRKRRVVSRIVGASLIENGKERRVENLTQPVRITFYHK 485

  Fly   388 NAK----ANETQFEGGCGYWNYE--TWLSDGISTSGGGSLEASSHPVILCHADHLTQFTFLLGVS 446
            .:.    :|.|     |.:||:.  .|...|...|.......|      |...|||.|..|:.|
Worm   486 ESSVRHLSNPT-----CVWWNHHELKWKPSGCKLSYHNKTMTS------CDCTHLTHFAVLMDV- 538

  Fly   447 KMQAGLDTNEDDHS-LDVITNVGLTLSLLGLLMIFITAAVFKSFRTLASTKILL--NLCAALGLQ 508
               .|.|.||.|.: |.::|.||..:|::.||:.|....:|.   .....::.:  |||.:|.:.
Worm   539 ---RGHDLNEIDQTLLTLLTYVGCIISIICLLLTFFAYLIFS---RNGGDRVFIHENLCLSLAIA 597

  Fly   509 LLFFLI-LSQSHLLEQLEQSESERCTLVGAVMQYLLLVVFSWMFIIGFLQYQRYVRVIGVNHPRH 572
            .:.||. ::::        .:|.:|.::...:.|:.|...:||.:.|: ...|.:..:..:.||.
Worm   598 EITFLAGITRT--------EDSLQCGIIAVALMYMFLSALTWMLLEGY-HIHRMLTEVFPSDPRR 653

  Fly   573 --YILMSAVAAWTLPLIPTLLVVFLEPGSYRPNNSSMDYPILCYPSGYGLSLGVIL-PIGLITVA 634
              |:|:..:.    |.|.||:       :|..|:.....|..|:.|.....:.... |...|..|
Worm   654 FTYLLVGYIP----PAIITLV-------AYLYNSDGFGTPDHCWLSTQNNFIWFFAGPACFIFCA 707

  Fly   635 NAILV-------------GYI--SWSVYTALFKRDLIFKQLGLFVLLFFLLGITWIFGLCTYFDF 684
            |::::             ||:  ...|.:....|:.:...|.    |..|||:||||||....|.
Worm   708 NSLVLVKTLCTVYQHTSGGYLPCRHDVDSGRSIRNWVKGSLA----LASLLGVTWIFGLFWVEDS 768

  Fly   685 GRI-FAYLFCLTATLQGFVLFLYFIVFNKENQR---AWL-----GLCCNSSKKRNQQTIQMPTDS 740
            ..| .||:|.::.:|||..:||:.:||.::.::   .|:     |...|||....:..:|  .|.
Worm   769 RSIVMAYVFTISNSLQGLFIFLFHVVFAEKMRKDVGHWMYRRGCGGSSNSSPNHKRHNVQ--RDL 831

  Fly   741 ILQGLSHSSTNS 752
            :..|: :|||.|
Worm   832 MSPGV-NSSTGS 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	55/243 (23%)
lat-1	NP_001366731.1	Gal_Lectin	51..133	CDD:396628
		HormR	180..244	CDD:214468	16/76 (21%)
		GAIN	258..462	CDD:406802	36/253 (14%)
		GPS	493..541	CDD:197639	16/62 (26%)
		7tmB2_latrophilin-like_invertebrate	548..808	CDD:320556	68/286 (24%)
		TM helix 1	551..575	CDD:320556	8/23 (35%)
		TM helix 2	584..605	CDD:320556	6/20 (30%)
		TM helix 3	615..637	CDD:320556	4/21 (19%)
		TM helix 4	655..671	CDD:320556	6/26 (23%)
		TM helix 5	690..713	CDD:320556	4/22 (18%)
		TM helix 6	744..766	CDD:320556	11/25 (44%)
		TM helix 7	771..796	CDD:320556	10/24 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910