DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15556 and Adgrl3

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	XP_008768190.1	Gene:	Adgrl3 / 170641	RGDID:	620836	Length:	1585	Species:	Rattus norvegicus

Alignment Length:	734	Identity:	172/734 - (23%)
Similarity:	273/734 - (37%)	Gaps:	167/734 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 ETDEGKEKRINRVEKTRVGQKAN----------LRDLCLNERGIPIRRRCQIRNGNRVWQSLDHV 132
            |:.|..|.|.....|||.||.|.          ...|||...||...:...:.|.:..|  ::|:
  Rat   563 ESCEAVEAREIMWFKTRQGQVAKQPCPAGTIGVSTYLCLAPDGIWDPQGPDLSNCSSPW--VNHI 625

  Fly   133 TCRSAPELSSSINLLAVKSPPDMISQLSNLLTQTQEKLAAADVFSISEIFDSLV----------- 186
            |.:             :||.....:....|..||:..|.|.|:.......|.||
  Rat   626 TQK-------------LKSGETAANIARELAEQTRNHLNAGDITYSVRAMDQLVGLLDVQLRNLT 677

  Fly   187 --------------KKPERNAAVVGDLMKICQKVMSTDNETLRVSADANATNALLSNFEDYLDEL 237
                          :|.||:...      ..|.::.|.|..|:..| .||...|.::     |:|
  Rat   678 PGGKDSAARSLNKLQKRERSCRA------YVQAMVETVNNLLQPQA-LNAWRDLTTS-----DQL 730

  Fly   238 SPTILKLNTTIFANSTEFTFHPLFDMGVIVLKTSELRVFFVDPEVRNVSGIVNFSGGNMSHFEML 302
            ....:.|:|.              :....||..:.|:...|.....|:            ..|:.
  Rat   731 RAATMLLDTV--------------EESAFVLADNLLKTDIVRENTDNI------------QLEVA 769

  Fly   303 HLS--DNEEDIRAMKNL--ESAVFIPEKLWTQLKRKGASYLVFKVYTRDSLFVETEEE-----IK 358
            .||  .|.||::..:|.  .|.:.:......|..|.|...:.|.:|.....::.||..     .:
  Rat   770 RLSTEGNLEDLKFPENTGHGSTIQLSANTLKQNGRNGEIRVAFVLYNNLGPYLSTENASMKLGTE 834

  Fly   359 RRPTSNVISITIPGL---------NDTKLPGKLPFFLRNAKANETQFEGGCGYWNYETWLSDGIS 414
            ...|::.:.:..|.:         |...|...:.|.:::.|.:|..|...|.:|:|......|..
  Rat   835 AMSTNHSVIVNSPVITAAINKEFSNKVYLADPVVFTVKHIKQSEENFNPNCSFWSYSKRTMTGYW 899

  Fly   415 TSGGGSLEASSHPVILCHADHLTQFTFLLGVSKMQAGLDTNEDD--HS--LDVITNVGLTLSLLG 475
            ::.|..|..::.....|..:|||.|..|:      |.::....|  |.  |||||.||:.|||:.
  Rat   900 STQGCRLLTTNKTHTTCSCNHLTNFAVLM------AHVEVKHSDAVHDLLLDVITWVGILLSLVC 958

  Fly   476 LLMIFITAAVFKSFRTLASTKILLNLCAALGLQLLFFLILSQSHLLEQLEQSESERCTLVGAVMQ 540
            ||:...|...|:..::..:| |..|||.:|.:..|.|||     .:.:.:|..:  |.:..|::.
  Rat   959 LLICIFTFCFFRGLQSDRNT-IHKNLCISLFVAELLFLI-----GINRTDQPIA--CAVFAALLH 1015

  Fly   541 YLLLVVFSWMFIIGFLQYQRYVRVIGVNHPRH-YILMSAVAAWTLPLIPTLLVVFLEPGSYRPNN 604
            :..|..|:|||:.|...|...|.|....|.|. |..:....      :|.|:|.......||...
  Rat  1016 FFFLAAFTWMFLEGVQLYIMLVEVFESEHSRRKYFYLVGYG------MPALIVAVSAAVDYRSYG 1074

  Fly   605 SSMDYPILCYPSGYGLSL------GVILPIGLITVANAILVGYISWSVY--TALFK--------- 652
            :..    :|:     |.|      ..|.|..||.:.|.|.:|...:.::  ||:.|
  Rat  1075 TDK----VCW-----LRLDTYFIWSFIGPATLIIMLNVIFLGIALYKMFHHTAILKPESGCLDNI 1130

  Fly   653 -----RDLIFKQLGLFVLLFFLLGITWIFGLCTYFDFGRIFAYLFCLTATLQGFVLFLYFIVFNK 712
                 |..|...:...:.|..|||:||.|||....:...|.||||.:..:|||..:|::..|..|
  Rat  1131 NYEDNRPFIKSWVIGAIALLCLLGLTWAFGLMYINESTVIMAYLFTIFNSLQGMFIFIFHCVLQK 1195

  Fly   713 ENQRAWLGLC----CNSSK 727
            :.::.: |.|    |.|.|
  Rat  1196 KVRKEY-GKCLRTHCCSGK 1213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	64/244 (26%)
Adgrl3	XP_008768190.1	Gal_Lectin	111..191	CDD:396628
		OLF	205..461	CDD:128580
		HormR	562..626	CDD:214468	18/64 (28%)
		GAIN	634..855	CDD:406802	46/258 (18%)
		GPS	881..933	CDD:197639	14/57 (25%)
		7tmB2_Latrophilin-3	941..1207	CDD:320671	81/289 (28%)
		TM helix 1	944..968	CDD:320671	13/23 (57%)
		TM helix 2	977..998	CDD:320671	10/26 (38%)
		TM helix 3	1008..1030	CDD:320671	6/21 (29%)
		TM helix 4	1049..1065	CDD:320671	4/21 (19%)
		TM helix 5	1084..1107	CDD:320671	6/22 (27%)
		TM helix 6	1143..1165	CDD:320671	9/21 (43%)
		TM helix 7	1169..1194	CDD:320671	10/24 (42%)
		Latrophilin	1207..1585	CDD:396778	3/7 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910