DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and ADGRA3

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_660333.2	Gene:	ADGRA3 / 166647	HGNCID:	13839	Length:	1321	Species:	Homo sapiens

Alignment Length:	789	Identity:	161/789 - (20%)
Similarity:	281/789 - (35%)	Gaps:	241/789 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 RRCQIRNGNRVWQSLDHVTCRSAPELSSSINLLAVKSPPDMISQLSNLLTQTQEKLA----AA-- 173
            |||. |.|  .|...|:..|:.|.:::..:.:.     ..|...|:|.:...::.||    ||
Human   398 RRCD-RGG--FWADDDYSRCQYANDVTRVLYMF-----NQMPLNLTNAVATARQLLAYTVEAANF 454

  Fly   174 ----DVFSISEIFDSLVK-KPERNAAVVGDLM-KICQKVMSTDNETLRVS-ADANATNALLSNFE 231
                ||..::|:.:...: ..|..:..:||:| .|...:|..|...|.:: .:|.|.:.::
Human   455 SDKMDVIFVAEMIEKFGRFTKEEKSKELGDVMVDIASNIMLADERVLWLAQREAKACSRIV---- 515

  Fly   232 DYLDELSPTILKLNTTIFANSTEFTFHPLFDMGVIVLKTSELRVFFVDPEVRNVSGIVNFSGGNM 296
            ..|..::...|.....:::     |:.|...:...|:|::                  .|:|...
Human   516 QCLQRIATYRLAGGAHVYS-----TYSPNIALEAYVIKST------------------GFTGMTC 557

  Fly   297 SHFEMLHLSD---------------------------NEEDIRAMKN--LESAVFIPEKLWTQLK 332
            :.|:.:..||                           |.....|:||  :|:::.:|..|::..:
Human   558 TVFQKVAASDRTGLSDYGRRDPEGNLDKQLSFKCNVSNTFSSLALKNTIVEASIQLPPSLFSPKQ 622

  Fly   333 RK------GASY-LVFKVYTRDSLFVET------EEEIKRRPTSNVISIT-IPGLN-DT-KLPGK 381
            ::      .:.| |....:....||..|      .::.|||.....:.:| |.|:| || .:|..
Human   623 KRELRPTDDSLYKLQLIAFRNGKLFPATGNSTNLADDGKRRTVVTPVILTKIDGVNVDTHHIPVN 687

  Fly   382 LPFFLR------NAKANETQF-----EGGCGYWNYETWLSDG---------ISTSGGGSLEASSH 426
            :.  ||      :|.|....|     :||        |.|||         |:|....||  |::
Human   688 VT--LRRIAHGADAVAARWDFDLLNGQGG--------WKSDGCHILYSDENITTIQCYSL--SNY 740

  Fly   427 PVI--LCHADHLTQFTFLLGVSKMQAGLDTNEDDHSLDVITNVGLTLSLLGLLMIFITAAVFKSF 489
            .|:  |..::..||...||               |.:...|.:.|.|.||.:::.:|........
Human   741 AVLMDLTGSELYTQAASLL---------------HPVVYTTAIILLLCLLAVIVSYIYHHSLIRI 790

  Fly   490 RTLASTKILLNLCAALGLQLLFFL-ILSQSHLLEQLEQSESERCTLVGAVMQYLLLVVFSWMFII 553
             :|.|..:|:|||..:.|..:.|: .::|:.        .:..|..||.::.|..|....|:.:.
Human   791 -SLKSWHMLVNLCFHIFLTCVVFVGGITQTR--------NASICQAVGIILHYSTLATVLWVGVT 846

  Fly   554 GFLQYQRYV----RVIGVNHP--------RHYILMSAVAAWTLPLIPTLLVVFLEPGSY--RPNN 604
            ....|::..    |....:.|        |.|::...:     |:|...:.......:|  |||
Human   847 ARNIYKQVTKKAKRCQDPDEPPPPPRPMLRFYLIGGGI-----PIIVCGITAAANIKNYGSRPN- 905

  Fly   605 SSMDYPILCYPSGYGLSLGVILPIGLITVAN---------------------------------- 635
              ..|..:.:....|...|   |...||..|
Human   906 --APYCWMAWEPSLGAFYG---PASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAAN 965

  Fly   636 ---------AILVGYISWSVYTALFKRDLIFKQL---GLFVLLFFLLGITWIFG---LCTYFDFG 685
                     ::.:..||.|   ||........||   .|.:||:..|   |:||   :..|:...
Human   966 ENGEINHQDSMSLSLISTS---ALENEHTFHSQLLGASLTLLLYVAL---WMFGALAVSLYYPLD 1024

  Fly   686 RIFAYLFCLTATLQGFVLFLYFIV---FNKENQR-AWLGLCC-NSSKKRNQQTIQMPTDSILQGL 745
            .:|:::|  .||...|..|  |:|   .|:|:.| ||:..|| ..|....|..:|.|..:...|.
Human  1025 LVFSFVF--GATSLSFSAF--FVVHHCVNREDVRLAWIMTCCPGRSSYSVQVNVQPPNSNGTNGE 1085

  Fly   746 SHSSTNSTS 754
            :....||::
Human  1086 APKCPNSSA 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	54/285 (19%)
ADGRA3	NP_660333.2	LRR_RI	<70..>182	CDD:238064
		LRR 1	82..103
		leucine-rich repeat	83..106	CDD:275378
		LRR_8	85..141	CDD:290566
		LRR 2	106..127
		LRR_4	107..146	CDD:289563
		leucine-rich repeat	107..130	CDD:275378
		LRR_8	129..182	CDD:290566
		LRR 3	130..151
		leucine-rich repeat	131..154	CDD:275378
		LRR 4	154..175
		leucine-rich repeat	155..178	CDD:275378
		LRRCT	189..>223	CDD:214507
		IG_like	249..341	CDD:214653
		Ig	262..337	CDD:143165
		HRM	<363..416	CDD:280888	8/20 (40%)
		LRR 5	594..620		7/25 (28%)
		GPS	704..743	CDD:280071	12/48 (25%)
		7tm_4	796..>945	CDD:304433	31/167 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1073..1094		5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1198..1219
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1231..1265
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1294..1321
		PDZ-binding. /evidence=ECO:0000255	1319..1321
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910