DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and Adgrg1

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	XP_006530743.1	Gene:	Adgrg1 / 14766	MGIID:	1340051	Length:	718	Species:	Mus musculus

Alignment Length:	731	Identity:	149/731 - (20%)
Similarity:	253/731 - (34%)	Gaps:	238/731 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 RDLCLN------ERGIPIRRRCQIRNGNRVWQSLDHVTCRSAPEL-------------SSSINLL 147
            |.||..      ::|.|:     |......||...:.:...||..             ::|:::.
Mouse   149 RLLCFQKQEQSLKQGAPL-----IATSVSSWQIPQNTSLPGAPSFIFSFHNAPHKVSHNASVDMC 208

  Fly   148 AVKSPPDMISQLSNLLTQTQEKLAAADVFSISEIFDSLVKKPERNAAVVGDLMKICQKVMSTDNE 212
            .:|..   :.|||..|...|:.........||:...||..| ..:.:.:||.:
Mouse   209 DLKKE---LQQLSRYLQHPQKAAKRPTAAFISQQLQSLESK-LTSVSFLGDTL------------ 257

  Fly   213 TLRVSADANATNALLSNFEDYLDELSPTILKLNTTIFANSTEFTFHPLFDMGVIVLKTSELRVFF 277
                            :||:  |.::.|:.||..|
Mouse   258 ----------------SFEE--DRVNATVWKLPPT------------------------------ 274

  Fly   278 VDPEVRNVSGIVNFSGGNMSHFEMLHLSDNEEDIRAMKNLESAVFIPEKLWTQL---KRKGASYL 339
                    :|:           |.||:...:|:.::.....| :.:|..::.|.   :|..|..|
Mouse   275 --------AGL-----------EDLHIHSQKEEEQSEVQAYS-LLLPRAVFQQTRGRRRDDAKRL 319

  Fly   340 VFKVYTRDSLFVETEEEIKRRPTSNVISITIPGL--NDTKL-----PGKLPFFLRNAKANETQFE 397
            :...::..:||.:       :.:|.|:...:.|:  .:||:     |..|.|..:....|.|.
Mouse   320 LVVDFSSQALFQD-------KNSSQVLGEKVLGIVVQNTKVTNLSDPVVLTFQHQPQPKNVTL-- 375

  Fly   398 GGCGYWNYETWLSDGISTSGGGSLEASSHPVILCHADHLTQFTFLLGVSKMQAGLDTNEDDHSLD 462
             .|.:|..:...|...|.|..|....|......|..:|||.|..|: ||..:... |::  |.|.
Mouse   376 -QCVFWVEDPASSSTGSWSSAGCETVSRDTQTSCLCNHLTYFAVLM-VSSTEVEA-THK--HYLT 435

  Fly   463 VITNVGLTLSLLGLLMIFITAAVFKSFRTLA--STKILLNLCAALGLQLLFFLILSQSHLLEQ-- 523
            :::.||..:|  .|..:|..||...|.|...  :.|:.:||.:|:       .:|..|.||.:
Mouse   436 LLSYVGCVIS--ALACVFTIAAYLCSRRKSRDYTIKVHMNLLSAV-------FLLDVSFLLSEPV 491

  Fly   524 -LEQSESERCTLVGAVMQYLLLVVFSWMFIIGFLQYQRYVRVIGVNHPRHYILMSAVAAWTLPLI 587
             |..||: .|......:.:.||...|||.:.|:..|:..|.|.|...| .|:|..::..|..|:.
Mouse   492 ALTGSEA-ACRTSAMFLHFSLLACLSWMGLEGYNLYRLVVEVFGTYVP-GYLLKLSIVGWGFPVF 554

  Fly   588 PTLLVVFLEPGSYRP-------NNSSMDYPILCYPSGYGLSLGVILPIGLITVANAILVGYISWS 645
            ...||..::..:|.|       ....:.||.:|:                   ....||.|::
Mouse   555 LVTLVALVDVNNYGPIILAVRRTPERVTYPSMCW-------------------IRDSLVSYVT-- 598

  Fly   646 VYTALFKRDLIFKQLGLFVLLFF----------------------------LLGITWIFGL---C 679
                         .||||.|:|.                            |||::.:.||   .
Mouse   599 -------------NLGLFSLVFLFNLAMLATMVVQILRLRPHSQNWPHVLTLLGLSLVLGLPWAL 650

  Fly   680 TYFDFGR-----IFAYLFCLTATLQGFVLFLYFIVFNKENQRAWLGLCCNSSKKRNQQTIQMPTD 739
            .:|.|..     :..|||.:..:.|||::||::.....:.|..      .|..|.|..:.::|
Mouse   651 VFFSFASGTFQLVILYLFSIITSFQGFLIFLWYWSMRFQAQGG------PSPLKNNSDSAKLP-- 707

  Fly   740 SILQGLSHSSTNSTSI 755
                 :|..||:|:.|
Mouse   708 -----ISSGSTSSSRI 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	60/269 (22%)
Adgrg1	XP_006530743.1	PLL	60..193	CDD:376013	10/48 (21%)
		GAIN_A	204..251	CDD:376045	12/50 (24%)
		GPS	376..419	CDD:366827	12/42 (29%)
		7tm_GPCRs	431..698	CDD:391938	71/319 (22%)
		TM helix 1	433..458	CDD:341315	8/26 (31%)
		TM helix 2	468..490	CDD:341315	8/28 (29%)
		TM helix 3	501..528	CDD:341315	7/26 (27%)
		TM helix 4	541..561	CDD:341315	5/19 (26%)
		TM helix 5	592..621	CDD:341315	9/43 (21%)
		TM helix 6	629..656	CDD:341315	6/26 (23%)
		TM helix 7	662..687	CDD:341315	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6570
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910