DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15556 and Adgre1

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001342651.1	Gene:	Adgre1 / 13733	MGIID:	106912	Length:	931	Species:	Mus musculus

Alignment Length:	809	Identity:	169/809 - (20%)
Similarity:	303/809 - (37%)	Gaps:	152/809 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LVSGGTNPPLYALDQ--PNVARCLDYCHLKNLRFLLCVDADGQLSHNPYKDCNRGFCKAEDFELE 76
            |.|.|..|....||:  .:|..|.....|....| :|::..|..|.:    |..|| ....|::.
Mouse   204 LESSGGGPMFQGLDESCEDVDECSRNSTLCGPTF-ICINTLGSYSCS----CPAGF-SLPTFQIL 262

  Fly    77 YETDEGKEKRINRVEKTRVGQKANLRDLCLNERGIPIRRRCQIR------NGNRVWQSLDHVTCR 135
            ....:|....|:..:.|     ..|...|.|..|...   |...      ||...::.|: |||.
Mouse   263 GHPADGNCTDIDECDDT-----CPLNSSCTNTIGSYF---CTCHPGFASSNGQLNFKDLE-VTCE 318

  Fly   136 SAPE-----LSSSINLLAVKSPPDMISQLSNLLTQTQEKLAAADVFSISEIF----DSLVKKPER 191
            ...|     |...:|.:....|...|...........|.......|:...|.    :.|:.:.|:
Mouse   319 DIDECTQDPLQCGLNSVCTNVPGSYICGCLPDFQMDPEGSQGYGNFNCKRILFKCKEDLILQSEQ 383

  Fly   192 NAAVVGDLMKICQKVMSTDNETLRVSADANATNALLSNFEDYLDELSPT-----------ILKLN 245
                    ::.||.|...|..........|||..:|.|..:  ::.:|.           :|:..
Mouse   384 --------IQQCQAVQGRDLGYASFCTLVNATFTILDNTCE--NKSAPVSLQSAATSVSLVLEQA 438

  Fly   246 TTIFANSTEFTFHPLFDMGVIVLKTSELRVFFVDPEVRNVSGIVNFSGGNMSHFEMLHLSDNE-- 308
            ||.|..|.|.|    ..:|.|:|:|.|          ..:...:....||.|........|.|
Mouse   439 TTWFELSKEET----STLGTILLETVE----------STMLAALLIPSGNASQMIQTEYLDIESK 489

  Fly   309 ---EDIRAMKNLESAV----------FIPEKLWTQLKRKGASYLVFKVYT------RDSLFVETE 354
               |:.:..:::..|.          .|.|.:.|     ||..:.|..:.      .:..|.:.:
Mouse   490 VINEECKENESINLAARGDKMNVGCFIIKESVST-----GAPGVAFVSFAHMESVLNERFFEDGQ 549

  Fly   355 EEIKRRPTSNVISITIPGLNDTKLPGKLPFFLRNAKANETQFEGGCGYWNYETWLSDGISTSGGG 419
            ...|.|..|.|:..|:.|.........:.:.|::.:..:......|..||  |.:.||..|..|.
Mouse   550 SFRKLRMNSRVVGGTVTGEKKEDFSKPIIYTLQHIQPKQKSERPICVSWN--TDVEDGRWTPSGC 612

  Fly   420 SLEASSHPVILCHADHLTQFTFLLGVSKMQAGLDTNEDDHSLDVITNVGLTLSLLGLLMIFITAA 484
            .:..:|....:|..:.:.....::...::..       :.||.:|::||..:||:.|.:...|..
Mouse   613 EIVEASETHTVCSCNRMANLAIIMASGELTM-------EFSLYIISHVGTVISLVCLALAIATFL 670

  Fly   485 VFKSFRTLASTKILLNLCAALGLQLLFFLILSQSHLLEQLEQSESE-RCTLVGAVMQYLLLVVFS 548
            :.::.:. .:|.:.|:||..|.|..:.|        |..::::::: .|.::...:.||.|..|.
Mouse   671 LCRAVQN-HNTYMHLHLCVCLFLAKILF--------LTGIDKTDNQTACAIIAGFLHYLFLACFF 726

  Fly   549 WMFIIGFLQY--QRYVRVIGVNHPRHYILMSAVA-AWTLPLIPTLLVVFLEPGSYRPNNSSMDYP 610
            ||.:...:.:  .|.::|:.....|:..::...| .:.||::..::...::|..|..:|.
Mouse   727 WMLVEAVMLFLMVRNLKVVNYFSSRNIKMLHLCAFGYGLPVLVVIISASVQPRGYGMHNR----- 786

  Fly   611 ILCY---PSGYGLS-LGVILPIGLITVANAILVGYISW-------SVYTALFK----RDLIFKQL 660
              |:   .:|:..| ||   |:.:|...|::|:.:..|       ||.:.:.|    |.|.||.
Mouse   787 --CWLNTETGFIWSFLG---PVCMIITINSVLLAWTLWVLRQKLCSVSSEVSKLKDTRLLTFKA- 845

  Fly   661 GLFVLLFFLLGITWIFGLCTYFDFGRIFAYLFCLTATLQGFVLFLYFIVFNKENQRAWLGLCCNS 725
               :...|:||.:|:.|:........|.||||.:..:|||..:||...:.|::.:        :.
Mouse   846 ---IAQIFILGCSWVLGIFQIGPLASIMAYLFTIINSLQGAFIFLIHCLLNRQVR--------DE 899

  Fly   726 SKKRNQQTIQMPTDSILQGLSHSSTNSTS 754
            .||...:...:.:.|...|:..||..|||
Mouse   900 YKKLLTRKTDLSSHSQTSGILLSSMPSTS 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	55/240 (23%)
Adgre1	NP_001342651.1	EGF_CA	33..63	CDD:238011
		EGF_CA	81..115	CDD:214542
		EGF_CA	133..172	CDD:214542
		EGF_CA	173..>203	CDD:214542
		EGF_CA	222..258	CDD:238011	10/41 (24%)
		EGF_CA	272..>301	CDD:214542	7/36 (19%)
		EGF_CA	319..352	CDD:214542	5/32 (16%)
		Cell attachment site. /evidence=ECO:0000255	506..508		0/1 (0%)
		GPS	591..640	CDD:197639	10/50 (20%)
		7tmB2_EMR	644..906	CDD:320555	68/292 (23%)
		TM helix 1	646..671	CDD:320555	9/24 (38%)
		TM helix 2	680..702	CDD:320555	8/29 (28%)
		TM helix 3	711..738	CDD:320555	6/26 (23%)
		TM helix 4	755..775	CDD:320555	3/19 (16%)
		TM helix 5	792..815	CDD:320555	8/25 (32%)
		TM helix 6	839..864	CDD:320555	9/28 (32%)
		TM helix 7	868..893	CDD:320555	10/24 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810