DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15556 and mthl11

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_731479.3	Gene:	mthl11 / 117467	FlyBaseID:	FBgn0045443	Length:	532	Species:	Drosophila melanogaster

Alignment Length:	274	Identity:	45/274 - (16%)
Similarity:	106/274 - (38%)	Gaps:	43/274 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   464 ITNVGLTLSLLGLLMIFITAAVF---KSFRTLASTKILLNLCAALGLQLLFFLILSQSHLLEQLE 525
            ::|..:.:....:..:.||.|.:   ..||:|...      |..     |:|:.|:.:.||..:.
  Fly   225 LSNASIPVKFSSVFFMVITIAAYLWLPKFRSLHGK------CCN-----LYFICLAITFLLNVIS 278

  Fly   526 -----QSESERCTLVGAVMQYLLLVVFSWMFIIGFLQYQRY-VRVIGVNHPR------HYILMSA 578
                 :.::..|.|.|....:.::..|.|:.:|.|..::|: :|...|.:..      :|.::..
  Fly   279 LFGIFELKTPICYLTGYAGYFTVMATFLWLSVISFDVWRRFAMRKFQVFYKNKRSSFFNYNIIVW 343

  Fly   579 VAAWTLPLIPTLLVVFLEPGSYRPNNSSMD-YPILCYPSGYGLSLGVILPIGLITVANAILVGYI 642
            .:|..|..|..|:..|:|.....|.|.::. :....:.:|:..:.....|:.::.:.|.......
  Fly   344 SSAGLLTCIIFLVDQFVETNLDNPYNPAVGVFSCWIFTNGWSATFYFYAPLAILIILNCASFFLT 408

  Fly   643 SWSVYTALFKRDLIFK------------QLGLFVLLFFLLGITWIFGLCTYF-DFGRIFAYLFCL 694
            :..:|....:...:..            ...::..||.::|.:|...:..:. :...::..|..|
  Fly   409 TRYIYVENKQNQKVLNNSEPQKLSRNHANYRIYFRLFIIMGGSWFLEIIAFICEMENMWKPLIIL 473

  Fly   695 TATL---QGFVLFL 705
            ...:   ||.::|:
  Fly   474 NDYINCSQGIIIFV 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	43/253 (17%)
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:310923
		7tmB3_Methuselah-like	236..504	CDD:320167	44/263 (17%)
		TM helix 2	258..280	CDD:320167	6/32 (19%)
		TM helix 3	291..318	CDD:320167	6/26 (23%)
		TM helix 4	335..355	CDD:320167	4/19 (21%)
		TM helix 5	383..412	CDD:320167	3/28 (11%)
		TM helix 6	433..460	CDD:320167	4/26 (15%)
		TM helix 7	468..493	CDD:320167	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900