Protein Alignment Ktch and adgrl2b.1

DIOPT Version :10

• Sequence 1: NP_651845.2
• Gene: Ktch / 43681
• FlyBaseID: FBgn0039821
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: XP_073767727.1
• Gene: adgrl2b.1 / 110437953
• ZFINID: ZDB-GENE-130116-4
• Length: 1467
• Species: Danio rerio
• Alignment Length: 792
• Identity: 167/792 - (21%)
• Similarity: 269/792 - (33%)
• Gaps: 226/792 - (28%)

  Fly    64 NRGFCKAEDFELEYETDEGKEKRINRVEKTRVGQKANLRDLCLNERGIPIRRRCQIRNGNR---- 124
            :|.||            |..|||.....||              .||:.:.|.|.  .|.|
Zfish   466 SRRFC------------EPTEKRGISWPKT--------------HRGLTVERPCP--RGTRGIAL 502

  Fly   125 -------VWQSLDHVTCRSAPELSSSIN------LLAVKSPPDMISQLSNLLTQTQEKLAAADVF 176
                   ||..       ..|:||:..:      ...::|..:..|..:.|...||..:.|.||.
Zfish   503 FLCLTGGVWNP-------KGPDLSNCTSHWVAQVAQKIRSGENAASLANELAHHTQGSVFAGDVS 560

  Fly   177 SISEIFDSLVK---------KPERNAAVVGDLMK------IC----QKVMSTDNETLRVSADANA 222
            |...:.:.||.         ||::..:......|      .|    :.::.|.:..||..|
Zfish   561 SSVRLMEQLVDILDAQLQELKPDQKDSPGRSFNKRQKRERTCRAYMKAIVDTVDNLLRPEA---- 621

  Fly   223 TNALLSNFEDYLDELSPTILKLNTTIFANSTEFTFHPLFDMGVIVLKTSELRVF-----FVDPEV 282
                |.::||                 .||||.|     ....::|.|.|...|     .::|.|
Zfish   622 ----LKSWED-----------------MNSTEQT-----HAATMLLDTLEEGAFVLADNLIEPAV 660

  Fly   283 RNVSG-------IVNFSGGNMSHFEMLHLSDNEEDIRAMKNLESAVFIPEKLWTQLKRK-GASYL 339
            ..:..       .|..:.|.:..|.....|.....|:...|:           .:|..| |.:.|
Zfish   661 VRMPAENIMLDVYVLSTDGQIQDFRFPQTSKRGATIQLSANM-----------VKLNSKNGVAKL 714

  Fly   340 VFKVYTRDSLFVETEEEIKR------------RPTSNVISITIPGLNDTKLPGKLPFFLRNAKAN 392
            ||.:|.....|:.||....|            ...|:::|.:|...:......:...|.......
Zfish   715 VFVLYKHLGHFLSTENATVRLMGDGGLRNHTLTVNSHILSASINKESSRVFVSEPVIFTLEHLDT 779

  Fly   393 ETQFEGGCGYWNYETWLSDGISTSGGGSLEASSHPVILCHADHLTQFTFLLGVSKMQAGLDTNED 457
            |..|...|.:|||......|..::.|..|.:::.....|...|||.|..|:          .:.|
Zfish   780 ENYFNPNCSFWNYSERSMSGYWSTQGCKLLSTNKTHTTCSCSHLTNFAILM----------VHRD 834

  Fly   458 DHS---------LDVITNVGLTLSLLGLLMIFITAAVFKSFRTLASTKILLNLCAALGLQLLFFL 513
            .|:         |.|||.:|:.:||:.|.:...|...|:..::..:| |..|||..|.:..|.||
Zfish   835 SHAGEGSVHELLLTVITRLGIAVSLVCLAISIFTFCFFRGLQSDRNT-IHKNLCINLFIAELLFL 898

  Fly   514 I---LSQSHLLEQLEQSESERCTLVGAVMQYLLLVVFSWMFIIGFLQYQRYVRVIGVNHPRH-YI 574
            :   :::..::          |:::..|:.:..|..||||.:.|...:...|.|......|. |.
Zfish   899 VGINMTEPPIV----------CSVIAGVLHFFFLAAFSWMCLEGVQLFLMLVEVFESEFSRRKYY 953

  Fly   575 LMSAVAAWTLPLIPTLLVVFLEPGSYRPNNSSMDYPILCYPSGYGLSLGVIL------------P 627
            ..|..      |.|.::|..         ::::||      ..||......|            |
Zfish   954 YASGY------LFPCVVVGI---------SAAIDY------KSYGTKKACWLRVDNHFIWSFIGP 997

  Fly   628 IGLITVANAILVGYISWSVYTALFKRDLIFKQ------------LGLFVLLFFLLGITWIFGLCT 680
            :..|.:.|.|   ::..::| .:.|..:..|.            .|.|.|| .||.:||.|||..
Zfish   998 VTFIILLNLI---FLVVTMY-KMVKHSMSMKPDSSRLESIRSWVFGAFALL-CLLCLTWSFGLLF 1057

  Fly   681 YFDFGRIFAYLFCLTATLQGFVLFLYFIVFNKENQRAW-----LGLCCNSSKKRNQQTIQMPTDS 740
            ..|...|.||||.:..||||..:|::..:..|:.::.:     ...||.:.......::...:.|
Zfish  1058 LNDSSVIMAYLFSIFNTLQGMFIFVFHCLLQKKVRKEYSKCFRQSQCCRTHPSEGPHSVNKSSAS 1122

  Fly   741 ILQGLSHSSTNS 752
            .......|:|.|
Zfish  1123 RSTARYSSATQS 1134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ktch	NP_651845.2	7tmB2_Adhesion	458..718	CDD:320168	71/296 (24%)
		TM helix 1	460..485	CDD:320168	9/33 (27%)
		TM helix 2	495..517	CDD:320168	9/24 (38%)
		TM helix 3	533..559	CDD:320168	7/25 (28%)
		TM helix 4	574..594	CDD:320168	4/19 (21%)
		TM helix 5	617..646	CDD:320168	7/40 (18%)
		TM helix 6	656..682	CDD:320168	12/37 (32%)
		TM helix 7	686..711	CDD:320168	10/24 (42%)
adgrl2b.1	XP_073767727.1	None