DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and adgrl2b.1

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001353776.1	Gene:	adgrl2b.1 / 110437953	ZFINID:	ZDB-GENE-130116-4	Length:	1454	Species:	Danio rerio

Alignment Length:	790	Identity:	168/790 - (21%)
Similarity:	267/790 - (33%)	Gaps:	235/790 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 NRGFCKAEDFELEYETDEGKEKRINRVEKTRVGQKANLRDLCLNERGIPIRRRCQIRNGNR---- 124
            :|.||            |..|||.....||              .||:.:.|.|.  .|.|
Zfish   466 SRRFC------------EPTEKRGISWPKT--------------HRGLTVERPCP--RGTRGIAL 502

  Fly   125 -------VWQSLDHVTCRSAPELSSSIN------LLAVKSPPDMISQLSNLLTQTQEKLAAADVF 176
                   ||..       ..|:||:..:      ...::|..:..|..:.|...||..:.|.||.
Zfish   503 FLCLTGGVWNP-------KGPDLSNCTSHWVAQVAQKIRSGENAASLANELAHHTQGSVFAGDVS 560

  Fly   177 SISEIFDSLVK---------KPER--------NAAVVGDLMKICQKVMSTDNETLRVSADANATN 224
            |...:.:.||.         ||::        |.|:|           .|.:..||..|
Zfish   561 SSVRLMEQLVDILDAQLQELKPDQKDSPGRSFNKAIV-----------DTVDNLLRPEA------ 608

  Fly   225 ALLSNFEDYLDELSPTILKLNTTIFANSTEFTFHPLFDMGVIVLKTSELRVF-----FVDPEVRN 284
              |.::||                 .||||.|     ....::|.|.|...|     .::|.|..
Zfish   609 --LKSWED-----------------MNSTEQT-----HAATMLLDTLEEGAFVLADNLIEPAVVR 649

  Fly   285 VSG-------IVNFSGGNMSHFEMLHLSDNEEDIRAMKNLESAVFIPEKLWTQLKRK-GASYLVF 341
            :..       .|..:.|.:..|.....|.....|:...|:           .:|..| |.:.|||
Zfish   650 MPAENIMLDVYVLSTDGQIQDFRFPQTSKRGATIQLSANM-----------VKLNSKNGVAKLVF 703

  Fly   342 KVYTRDSLFVETEEEIKR------------RPTSNVISITIPGLNDTKLPGKLPFFLRNAKANET 394
            .:|.....|:.||....|            ...|:::|.:|...:......:...|.......|.
Zfish   704 VLYKHLGHFLSTENATVRLMGDGGLRNHTLTVNSHILSASINKESSRVFVSEPVIFTLEHLDTEN 768

  Fly   395 QFEGGCGYWNYETWLSDGISTSGGGSLEASSHPVILCHADHLTQFTFLLGVSKMQAGLDTNEDDH 459
            .|...|.:|||......|..::.|..|.:::.....|...|||.|..|:          .:.|.|
Zfish   769 YFNPNCSFWNYSERSMSGYWSTQGCKLLSTNKTHTTCSCSHLTNFAILM----------VHRDSH 823

  Fly   460 S---------LDVITNVGLTLSLLGLLMIFITAAVFKSFRTLASTKILLNLCAALGLQLLFFLI- 514
            :         |.|||.:|:.:||:.|.:...|...|:..::..:| |..|||..|.:..|.||:
Zfish   824 AGEGSVHELLLTVITRLGIAVSLVCLAISIFTFCFFRGLQSDRNT-IHKNLCINLFIAELLFLVG 887

  Fly   515 --LSQSHLLEQLEQSESERCTLVGAVMQYLLLVVFSWMFIIGFLQYQRYVRVIGVNHPRH-YILM 576
              :::..::          |:::..|:.:..|..||||.:.|...:...|.|......|. |...
Zfish   888 INMTEPPIV----------CSVIAGVLHFFFLAAFSWMCLEGVQLFLMLVEVFESEFSRRKYYYA 942

  Fly   577 SAVAAWTLPLIPTLLVVFLEPGSYRPNNSSMDYPILCYPSGYGLSLGVIL------------PIG 629
            |..      |.|.::|..         ::::||      ..||......|            |:.
Zfish   943 SGY------LFPCVVVGI---------SAAIDY------KSYGTKKACWLRVDNHFIWSFIGPVT 986

  Fly   630 LITVANAILVGYISWSVYTALFKRDLIFKQ------------LGLFVLLFFLLGITWIFGLCTYF 682
            .|.:.|.|   ::..::| .:.|..:..|.            .|.|.|| .||.:||.|||....
Zfish   987 FIILLNLI---FLVVTMY-KMVKHSMSMKPDSSRLESIRSWVFGAFALL-CLLCLTWSFGLLFLN 1046

  Fly   683 DFGRIFAYLFCLTATLQGFVLFLYFIVFNKENQRAW-----LGLCCNSSKKRNQQTIQMPTDSIL 742
            |...|.||||.:..||||..:|::..:..|:.::.:     ...||.:.......::...:.|..
Zfish  1047 DSSVIMAYLFSIFNTLQGMFIFVFHCLLQKKVRKEYSKCFRQSQCCRTHPSEGPHSVNKSSASRS 1111

  Fly   743 QGLSHSSTNS 752
            .....|:|.|
Zfish  1112 TARYSSATQS 1121

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	60/249 (24%)
adgrl2b.1	NP_001353776.1	Gal_Lectin	50..130	CDD:307994
		OLF	139..395	CDD:321983
		HormR	468..528	CDD:214468	19/94 (20%)
		GAIN	538..746	CDD:318649	53/259 (20%)
		GPS	770..822	CDD:197639	14/61 (23%)
		7tm_GPCRs	831..1088	CDD:333717	70/293 (24%)
		TM helix 1	834..858	CDD:320672	9/23 (39%)
		TM helix 2	867..888	CDD:320672	9/21 (43%)
		TM helix 3	898..920	CDD:320672	6/21 (29%)
		TM helix 4	939..955	CDD:320672	5/30 (17%)
		TM helix 5	974..997	CDD:320672	4/25 (16%)
		TM helix 6	1021..1046	CDD:320672	11/25 (44%)
		TM helix 7	1050..1075	CDD:320672	10/24 (42%)
		Latrophilin	1087..1454	CDD:308136	6/35 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900