DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and LOC101735190

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	XP_031758868.1	Gene:	LOC101735190 / 101735190	-ID:	-	Length:	1023	Species:	Xenopus tropicalis

Alignment Length:	724	Identity:	146/724 - (20%)
Similarity:	250/724 - (34%)	Gaps:	183/724 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 TRVGQKANLRDLCLNERGIPIRRRCQIRNGNRVWQSLDHVTCRSAPELSSSINLLAVKSPPDMIS 157
            ||.|.:..:.  |.:|:.....|.|   :.|..|..::. .|.|          ||:|:..:...
Frog   401 TRAGLQTTVS--CASEKSGNQTRNC---SANGQWMEVED-NCIS----------LALKNALNDAQ 449

  Fly   158 QLSNLLTQTQEKL----------------------AAADVFSISEIFDSLVKKPERNAAVVGDLM 200
            .|.|.|...|||:                      |...:..|.....:.:..| .||:||.|.:
Frog   450 ALKNGLGNLQEKVPAILMAVSDPSAVSVTNSAGVTALVSILGIISTVSTNMNMP-FNASVVTDFL 513

  Fly   201 KICQKVMSTDNETLRVSADANATNALLSNFEDYLDELSPTILKLNTTIFANSTEFTFHPLFDMGV 265
            .:...:......:|..::.:.|.:.::.:.|.:     .|:||.:...|..|.:          .
Frog   514 AVASNLSDPSLSSLWKTSRSPAASDMMKSAEQF-----GTLLKADNNTFGISLQ----------N 563

  Fly   266 IVLKTSEL-RVFFVDPEVR---NVSGIVNFSGGNMSHFEMLHLSDNEEDIRAMKNLESAVFIPEK 326
            |.||.|.. ....:|...:   .::|:..|.              |:|.|.||...::..
Frog   564 IQLKGSSYGNKSIIDDYAKTFDGINGVTTFI--------------NKETIAAMLATDNIT----- 609

  Fly   327 LWTQLKRKGASYLVFKVYTRDSLFVETEEEIKRRPTSNVI-SITIPGLNDTKLPGKLPF-FLRNA 389
                     .:.|||.. ..|.|...|.........::|| |.:|.....|.|.|::.. |..|.
Frog   610 ---------VTSLVFNT-IGDLLANSTTGPFNGTQLNSVIQSTSIKSAGSTNLSGEISMNFTTNV 664

  Fly   390 KANETQFEGGCGYWNYET------WLSDGISTSGGGSLEASSHPVILCHADHLTQFTFLLGVSKM 448
            ..  :.::..|.:|::..      |...|.:|:...||..       |..:|||.|..|:.::
Frog   665 SG--SNYQQRCAFWDFSQPIAGGGWSDRGCTTNVEDSLTT-------CTCNHLTSFAVLMSIN-- 718

  Fly   449 QAGLDTNEDDHSLDVITNVGLTLSLLGLLMIFIT-AAVFKS--------FRTLASTKILLNLCAA 504
                  :|....:|.||..||..|:|.|.:..|| ..|:||        ||.::...|.::|..|
Frog   719 ------SEPLLFIDEITYAGLGASILSLCVCIITECLVWKSVVRNNISYFRHISLVNIAVSLLFA 777

  Fly   505 LGLQLLFFLILSQSHLLEQLEQSESERCTLVGAVMQYLLLVVFSWMFIIGFLQYQRYVRVIGVNH 569
               ..|||.....|      ..:....|..:..:..:..|.:|.|.|....:...:.:.|.  :|
Frog   778 ---DTLFFAATFPS------VTNYKFICLSITFLNHFFYLALFFWTFCQSVMLLHQLLFVF--HH 831

  Fly   570 PRHYILMSAVAAWTLPLIPTLLV--VFLEPGSYRPNNSSMDYPILCYPSGYGLSLGVILPIGLIT 632
            .|..|.:| ::.:....||.|:.  .||   .:.|.|:.:...:.......|......:|.|.|
Frog   832 LRKRIFLS-LSFFVGYFIPALIAAGTFL---YFYPKNTYLHQSVCWLNPESGAIYTFAIPAGSI- 891

  Fly   633 VANAILVGYISWSVYTALFKRDLIFKQ------------LGLFVLLFFLLGITWIFGLCTYFDFG 685
                |:..:::..|..:...|..:.:.            :...::|..:.|:||.||.....|..
Frog   892 ----IMFNFMTLMVVISKLSRPSVSEANRPEDRETAKSIMKAVLVLTPVFGLTWSFGFALLKDLD 952

  Fly   686 ----RIFAYLFCLTATLQGFVLFLYFIVFNKENQRAWLGLCCNSSKKRNQQTIQMPTDSILQGLS 746
                :||.|.|......|||.:.|               .|....|.|         |::...:|
Frog   953 SLTRQIFTYGFAGLNAFQGFFILL---------------TCLTEKKVR---------DALTNKVS 993

  Fly   747 HSSTNSTSI 755
            ..:|:||.:
Frog   994 SLNTSSTKL 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	52/248 (21%)
LOC101735190	XP_031758868.1	SEA	88..182	CDD:396113
		HRM	384..438	CDD:397086	10/42 (24%)
		GAIN	<509..646	CDD:406802	32/180 (18%)
		GPS	672..714	CDD:396408	12/48 (25%)
		7tmB2_GPR113	722..994	CDD:320381	65/315 (21%)
		TM helix 1	725..749	CDD:320381	10/23 (43%)
		TM helix 2	764..785	CDD:320381	6/23 (26%)
		TM helix 3	797..819	CDD:320381	4/21 (19%)
		TM helix 4	840..856	CDD:320381	3/15 (20%)
		TM helix 5	877..900	CDD:320381	5/27 (19%)
		TM helix 6	927..949	CDD:320381	6/21 (29%)
		TM helix 7	957..981	CDD:320381	9/38 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910