DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and adgrf8

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	XP_021324214.1	Gene:	adgrf8 / 100537224	ZFINID:	ZDB-GENE-130531-41	Length:	1719	Species:	Danio rerio

Alignment Length:	809	Identity:	164/809 - (20%)
Similarity:	280/809 - (34%)	Gaps:	198/809 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WIAGYIILVSGGTNPPLYALDQPNVARCLD----YCHLKNLRFLLCV----------DADGQLSH 57
            |:.|..:.||......:.......:..|..    .|.||.|..||..          :.|.|..
Zfish  1010 WVQGETVQVSESAADGITLNYASQIGNCTQEQTFTCRLKGLPALLIYGYSQSSVIVKNTDQQYD- 1073

  Fly    58 NPYKDCNRGFCKAEDFELEYETDEGKEKRINRVEKTRVGQKANLRDLCLNERGIPIRRRCQIRNG 122
                      |:.|:..|..:.::.     |.:..|  |.|..:...|.::...||:..|.:
Zfish  1074 ----------CQNEELGLGNQNEQR-----NGICPT--GTKGIITYECDSKAWRPIKENCIL--- 1118

  Fly   123 NRVWQSLDHVTCRSAPELSSSINLLAVKSPPDMISQLS-----NLLTQTQEKLAAADVFSISEIF 182
                        ....:|.:.|.:|.|...|..:|.||     |.:..||   :||.|.:|.:|.
Zfish  1119 ------------GVISDLLTQIPVLQVGQIPSFLSNLSFATEQNNINITQ---SAATVKAIVDIL 1168

  Fly   183 DSLVKKPERNAAVVGDLMKICQKVMSTDNETLRVSADANATNALLSNFEDYLDELSPTILKLNTT 247
            ..:....:  .|::|      ..||::..:||.:....|:|..                  .||.
Zfish  1169 SQIANLAQ--TALIG------PPVMNSFLKTLDIIVSTNSTET------------------WNTL 1207

  Fly   248 IFANSTEFTFHPLFDMGVIVLKTSE-LRVFFVDPEVRNVSGI------VNFSGGNMSHFEMLHLS 305
            ...|:||.|       .:.:||.:| :....:|....|::.|      ||.|....|
Zfish  1208 NNDNTTENT-------NIKLLKATETISDRLIDQFTVNLTSIQLSRTTVNSSLSVTS-------- 1257

  Fly   306 DNEEDIRAMKNLESAVFIPEKLWTQLKRKGASYLVFKVYTRDSLFVETEEEIKRRPTSNVISITI 370
                   .:.|..:.:.||:              ||...|...:...|.:.|  .||.|:.:...
Zfish  1258 -------TLSNSTTEIVIPQ--------------VFGPTTATIIIFTTLDNI--LPTRNISNNNS 1299

  Fly   371 PGLNDTKLPG--------------KLPFFLRNAKANETQFEGGCGYWNY--ETWLSDGISTSGGG 419
            ..::|.::.|              ...|.:.|......|    |.:||:  ..|.|.|......|
Zfish  1300 SDISDQRINGDVVVVKVDKTVNNISFAFDITNQSLGNPQ----CVFWNFNLSAWDSTGCEVKQVG 1360

  Fly   420 SLEASSHPVILCHADHLTQFTFLLGVSKMQAGLDTNEDDHSLDVITNVGLTLSLLGL-LMIFITA 483
                :...:|.|..:|.|.|:.|:....:        |...|..||.:|:|:|::.| |.:.|.|
Zfish  1361 ----NDSGIITCECNHTTSFSILMSPFIL--------DSLILAYITYIGVTISMISLVLCLIIEA 1413

  Fly   484 AVFKSFRTLASTKI---------LLNLCAALGLQLLFFLILSQSHLLEQLEQ-SESERCTLVGAV 538
            .|::|..:.....:         |:|:..:|.:..:.|:|   ...:..||: :...||:.|...
Zfish  1414 IVWRSVTSARGVTVVSSYMRHISLVNIALSLLIANVCFII---GAAISDLEKPTPVGRCSPVVFF 1475

  Fly   539 MQYLLLVVFSWMFIIGFLQYQRYVRVIGVNHPRHYILMSAVAAWTLPLIPTLLVVFLEPGSYRPN 603
            :.:..|.||.||.|.|.|.....|.|.|.......|.:|....:..||:...:.|....|   |.
Zfish  1476 IHFFYLAVFFWMLISGMLLLYMTVMVFGQMSRIKMIAISFPVGYGAPLLIASITVASTAG---PQ 1537

  Fly   604 N-SSMDYPILCYPSGYGLSLGVILPIGLITVANAILVGYISWSVY-------TALFKRDLIFKQL 660
            | .|.....|.:.....| |..::|...|...|.:::..:.:.:.       |...:::..|..:
Zfish  1538 NYVSKQACWLNWNESRAL-LAFVIPALTIVAINLVVLVVVLYKMLGTGVGAATQPSEKNTFFVVV 1601

  Fly   661 GLFVLLFFLLGITWIFGLCTYFDFGRIFAYLFCLTATLQGFVLFLYFIVFNKENQRAWLGLCCNS 725
            .....|..|.|:||.||:.|..........||.|....|||.:.|:..:.:.:.:.|..|
Zfish  1602 RCVAFLTPLFGLTWGFGIGTMLSSALGVHVLFTLLNAFQGFFILLFGTILDAKVREALRG----- 1661

  Fly   726 SKKRNQQTIQMPTDSILQGLSHSSTNSTS 754
                     ::..|.:...::.|::...|
Zfish  1662 ---------KLQIDKLASRITQSTSGGAS 1681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	56/239 (23%)
adgrf8	XP_021324214.1	EGF_CA	156..189	CDD:214542
		EGF_CA	324..357	CDD:214542
		EGF_CA	508..>540	CDD:214542
		EGF_CA	673..706	CDD:214542
		Ig	899..968	CDD:325142
		GPS	1337..1379	CDD:307782	13/49 (27%)
		7tm_GPCRs	1387..1660	CDD:333717	66/279 (24%)
		TM helix 1	1390..1414	CDD:320095	9/23 (39%)
		TM helix 2	1434..1455	CDD:320095	5/23 (22%)
		TM helix 3	1470..1492	CDD:320095	7/21 (33%)
		TM helix 4	1513..1529	CDD:320095	3/15 (20%)
		TM helix 5	1551..1574	CDD:320095	5/23 (22%)
		TM helix 6	1598..1623	CDD:320095	9/24 (38%)
		TM helix 7	1627..1652	CDD:320095	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900