DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15556 and dnai2

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	XP_031750209.1	Gene:	dnai2 / 100495747	XenbaseID:	XB-GENE-854694	Length:	593	Species:	Xenopus tropicalis

Alignment Length:	489	Identity:	98/489 - (20%)
Similarity:	156/489 - (31%)	Gaps:	171/489 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 QLSHNPYKDCNRGFCKAEDFELE----YETDEGKEKRIN------------RVEK-----TRVGQ 97
            |.||    :.:......|.:|:|    ...:.|..|.||            :|||     ..:.|
Frog    58 QCSH----EMSEHEVNTERYEMEARGINHVEGGWPKDINPQEMEQTIRFRKKVEKDDHYIATISQ 118

  Fly    98 KANLRDLCLNERGIPIRRRCQIRNGNRVWQSLDHVTCRSAPEL-----SSSINLLAVKSPPDMIS 157
            ..::.:.|:.:           .|...:::.....|    .||     :.|.|.:.|...|:.|.
Frog   119 LGSVMEHCIKQ-----------NNAINIYEEYFEDT----EELEGMDETPSANTVNVFRDPNEIK 168

  Fly   158 QLSNLLT---QTQEKLAAA-----------DVFSISEIFD-SLVKKPERNAAVVGDLMKICQKVM 207
            :.:..|:   ....|||.|           |:...|.|:| .:..|||.....|..|  :|.:..
Frog   169 RTATHLSWHPDGSRKLAVAYSCLDFQRAPKDMSYESYIWDIEIPNKPELTLKPVSPL--VCLEYN 231

  Fly   208 STDNETLRVSADANATNALLSNFEDYLDEL---SPTILKLNTTIFANSTEFTFHPLFDMGVIVLK 269
            ..|:..| |....|...|       |.|..   :|    :.:|:..:|..   .|::.  ||.|:
Frog   232 PKDSHVL-VGGCYNGQIA-------YWDTRKGGNP----MESTVIEHSHR---DPVYK--VIWLQ 279

  Fly   270 TSELRVFFVDPEVRNVSGIVNFSG---GNMSHFEMLHLSDNEE----DIRAMKNLESAV------ 321
            :.              :|...||.   |.:..:::..||:..|    ||...:||::|:
Frog   280 SK--------------TGTECFSASTDGQILWWDIRKLSEPTEKLILDISKKENLDNALGAVSLE 330

  Fly   322 ---FIPEKLWTQLKRKGASYLVFKVYTRDSLFVETEEEIKRRPTSNVISITIPGLNDTKLPGKL- 382
               .:|.|              |.|.|...:.|....:.|..|..  |..|..|.:     |.:
Frog   331 FEPTLPTK--------------FMVGTEQGMIVSCNRKAKTPPEK--IVCTYGGHH-----GPIY 374

  Fly   383 -----PFFLRNAKANETQFEGGCGYWNYETWLSDGISTSGGGSLEASSHPVILCHADHLTQ---- 438
                 ||:.:|...        .|.|....|..|         ...||......|..:||.
Frog   375 SIQRNPFYPKNFLT--------VGDWTARIWSED---------CRESSIMWTKYHMSYLTDACWS 422

  Fly   439 ----FTFLLGVSKMQAGLDT-----NEDDHSLDV 463
                ..||  .:||...||.     .:::.||.|
Frog   423 PTRPTVFL--TTKMDGTLDVWDYMYKQNNPSLSV 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433
dnai2	XP_031750209.1	WD40 repeat	105..141	CDD:293791	6/46 (13%)
		WD40	<172..495	CDD:225201	74/356 (21%)
		WD40 repeat	172..221	CDD:293791	12/48 (25%)
		WD40 repeat	226..265	CDD:293791	10/50 (20%)
		WD40 repeat	273..314	CDD:293791	10/56 (18%)
		WD40 repeat	326..367	CDD:293791	10/56 (18%)
		WD40 repeat	373..409	CDD:293791	9/52 (17%)
		WD40 repeat	416..441	CDD:293791	8/26 (31%)
		tolA_full	<509..>593	CDD:274303
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900