Protein Alignment Ktch and adgrd1

DIOPT Version :10

• Sequence 1: NP_651845.2
• Gene: Ktch / 43681
• FlyBaseID: FBgn0039821
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: XP_002931944.3
• Gene: adgrd1 / 100494370
• XenbaseID: XB-GENE-980829
• Length: 983
• Species: Xenopus tropicalis
• Alignment Length: 915
• Identity: 180/915 - (19%)
• Similarity: 317/915 - (34%)
• Gaps: 287/915 - (31%)

  Fly    14 LVSGGTNPPLYA---LDQPNVARCLDYCHLKNLRFLLCVDADGQLSHNPYKDCNRG------FCK 69
            :|.|..|..:|.   |::||....|.:...||    .|:.       || ..|...      |.|
 Frog   165 IVEGTVNQGIYLNEHLNEPNGFSLLYFGSYKN----SCIS-------NP-SICGPSGVTFSFFWK 217

  Fly    70 AEDFELEYETDEGKEKRINRVEKTRVGQKANLR--DLCLNER-GIPIRRRCQIRNGNR--VWQSL 129
            .||     :.:..::.:.|:.:....|:|....  ::..||: |..:     :.|.|:  :|:
 Frog   218 IED-----QKENNQDHQQNKKQAHASGKKVTSSGFEVFSNEKEGYVV-----VYNHNKSLIWK-- 270

  Fly   130 DHVTCRSAPELSSSINLLAVKSPPDM--------ISQLSNLLTQTQEKLAAADVF-----SISEI 181
                        :.||      ||.:        .:.|..|........:|:|.:     |..:.
 Frog   271 ------------AKIN------PPGLHWTHVLFTWTSLDGLKIYVNGTFSASDSYGQEFHSYGDA 317

  Fly   182 FDSLV-------KKPERNAAVVGDLMKICQKVM-----------STDNETLRVSADANATN---- 224
            ..|||       .|...|.|.  |...|.::.:           :|..|....|..:|...
 Frog   318 KGSLVVGTSTDSSKHYINCAF--DEFVIWERALNPSDIHFYFLAATGKEAFITSTTSNIPGTSLP 380

  Fly   225 --------ALLSNFE-------------DYLDELSPTILK--LNTTIFANSTEFTFHPLFDMGVI 266
                    ::|.|..             |.|..::..:.|  |:.....|.|: .|  |..:|.:
 Frog   381 TVSTDVYYSILFNLNQEGRRFHHSKPALDLLQNVTQALPKKSLSKDTAGNLTQ-AF--LKTVGEV 442

  Fly   267 VLKTSELRVFFVDPEVRNVSGIVNFSGGNMSHFE------MLHLSDNEEDIRAMKNLESA----- 320
            :..||           .:||...:::||.:...:      .::|.:|..||..::...|.
 Frog   443 MTATS-----------TDVSPSQDYAGGLIEMVDKVTGQTAVNLQENLTDIVTLEGKSSVADYSM 496

  Fly   321 VFIPEKLWTQLKR---KGASYL-----VFKVYTRDSLF-----------------------VETE 354
            |.:|:.|.....|   :|.||:     .|:..:|.::.                       .|..
 Frog   497 VKVPQALSLSHYRFPSQGQSYISVPGEAFQNKSRTTIVGLLYHTMHYLYKWIKPSDTRISGAEKY 561

  Fly   355 EE----------IKRRPTSNVIS-------ITI------------PGLNDTKLPGKLPFFLRNAK 390
            |:          :|..|..|:.:       |||            ..:||:........||..:.
 Frog   562 EDHLIAASYIISLKVEPPPNLSANLSGSPLITIQLTHILTPKLYAEAVNDSNKVYMYCAFLNFSS 626

  Fly   391 ANETQFEGGC----GYWNYETWLSDGISTSGGGSLEASSHPVILCHADHLTQFTFLLGVSKMQAG 451
            .:......||    |.|||.                       :|..:|||.|..|:.|...:.
 Frog   627 GSGIWSNEGCVRVEGNWNYS-----------------------VCRCNHLTNFAILMQVVPFKV- 667

  Fly   452 LDTNEDDH--SLDVITNVGLTLSLLGLLMIFITAAVFKSFRTLASTKILLNLCAALGLQLLFFLI 514
                .:.|  :|..||.:|.:||:..|.:..:|.|:..|..|:.:.:..::      ..|.|.::
 Frog   668 ----PESHKVALSSITYIGCSLSIFCLAITLVTFAILSSVSTIRNQRYHIH------ANLSFAIL 722

  Fly   515 LSQSHLLEQLE-QSESERCTLVGAVMQYLLLVVFSWMFIIGFLQYQRYVRVIGVNHPRHYILMSA 578
            ::|..||.... .|.:..|.::..::.:..|..|:||.:.|...|...::|.|....:|:....
 Frog   723 VAQILLLISFRFVSGTLPCKIIAILLHFFFLSAFAWMLVEGLHLYSMVIKVFGSEESKHFYYYG- 786

  Fly   579 VAAWTLPLIPTLLVVFLEPGSY--RPNNSSMDYPILCYPSGYGLSLG------------VILPIG 629
             ..|...|:..::.|.....||  |.|         |:.|   |..|            :::.||
 Frog   787 -IGWGSSLVICIVSVTSALDSYGERAN---------CWLS---LEKGAIWAFVAPALFVIVVNIG 838

  Fly   630 LITVANAILVGYISWSVYTALFKRDL-IFKQLGLFV-LLFFLLGITWIFGLCTYFDFGRIFAYLF 692
            :: :|...::..||...|..  .||. .||.....| :|..:||.:|:||:....:...:|.|:|
 Frog   839 IL-IAVTRIISRISADNYKV--HRDANAFKLTAKAVAVLLPILGSSWVFGVLAVNEQAIVFQYMF 900

  Fly   693 CLTATLQGFVLFLYFIVFN-------KENQRAWLGLCCNSSKKRNQQTIQMPTDSILQGLSHSST 750
            .:..:||||.:||:..:.|       |...:.|   ...||..||...  .|.:|.:...:.::|
 Frog   901 AIFNSLQGFFIFLFHCLLNSEVRAAFKHKTKVW---SLTSSSIRNINV--KPFNSDIMNGNRANT 960

  Fly   751 NSTSI 755
            :.|.:
 Frog   961 SPTKM 965

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ktch	NP_651845.2	7tmB2_Adhesion	458..718	CDD:320168	67/285 (24%)
		TM helix 1	460..485	CDD:320168	8/24 (33%)
		TM helix 2	495..517	CDD:320168	2/21 (10%)
		TM helix 3	533..559	CDD:320168	5/25 (20%)
		TM helix 4	574..594	CDD:320168	2/19 (11%)
		TM helix 5	617..646	CDD:320168	7/40 (18%)
		TM helix 6	656..682	CDD:320168	9/26 (35%)
		TM helix 7	686..711	CDD:320168	9/24 (38%)
adgrd1	XP_002931944.3	Laminin_G_3	<280..353	CDD:463865	13/74 (18%)
		GPS	619..659	CDD:460350	13/62 (21%)
		7tmB2_GPR133	672..931	CDD:320384	66/281 (23%)
		TM helix 1	674..699	CDD:320384	8/24 (33%)
		TM helix 2	711..733	CDD:320384	5/27 (19%)
		TM helix 3	742..769	CDD:320384	6/26 (23%)
		TM helix 4	781..799	CDD:320384	3/19 (16%)
		TM helix 5	818..847	CDD:320384	4/29 (14%)
		TM helix 6	863..890	CDD:320384	9/26 (35%)
		TM helix 7	894..919	CDD:320384	9/24 (38%)