DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and celsr3

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	XP_009302289.1	Gene:	celsr3 / 100008568	ZFINID:	ZDB-GENE-070122-3	Length:	3666	Species:	Danio rerio

Alignment Length:	850	Identity:	178/850 - (20%)
Similarity:	288/850 - (33%)	Gaps:	212/850 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 YCHLKNLRFL-----LCVDAD----GQLSH--NPYK---DCNRGF----CKAEDFELEYETDEGK 83
            :||.|...:.     :|:..|    |..|.  :|..   .|..|.    |...|......|..|.
Zfish  2429 HCHCKEFHYRRRGSDICLPCDCYPVGSFSRSCDPESGQCQCRPGVIGRQCNMCDNPFAEVTQTGC 2493

  Fly    84 EKRINRVEKTRVG------QKANLRDLCLNERGIPIR--------RRCQIRNGNRVWQSLDHVTC 134
            |...:...||...      .|.||      ...:|..        |.|   :|.|.|...|...|
Zfish  2494 EVIYDGCPKTITSAIWWPRTKFNL------PAAVPCPKGSVGTAIRHC---DGERGWLDPDLYNC 2549

  Fly   135 RSAP--ELSSSINLLAVKSPPDMISQLSNLLTQTQEKLAAADVFSISEIFDSLVKKPERNAAVVG 197
            .|.|  ||::::..|....        :.|.|..::|||           ..|....|..:.:.|
Zfish  2550 TSPPFVELNTALESLERNE--------TELNTIIEKKLA-----------HQLRDVTEATSRLYG 2595

  Fly   198 DLMKICQKVMS--------TDNETLRVSADANATNALLSNFEDYLDELSPTILKLNTTIFANSTE 254
            :.::|.::::|        .....|..:.||:....:|......|...|.::.:..::  ..|..
Zfish  2596 NDLQIAERLLSRLLTFESLQSGFGLTATQDAHFNENVLRGCSVLLGPASASLWRAQSS--GQSGA 2658

  Fly   255 FTFHPLFDMGVIVLKTSELRVFFVDPEVRNVSGIVNFSGGNMSHFEMLHLSDNEEDI-RAMKNLE 318
            .....|.:....:| ...::..:::|.......||          ..|...||...: |......
Zfish  2659 AGLADLLEQYTRIL-AQNMKQTYLNPVALVAPNIV----------MTLDRVDNHTHVRRRFPRYH 2712

  Fly   319 SAVFIPEKLW---TQLKRKGASYL----VFKV------------YTRDSLFVETEEEIKRRPTSN 364
            |.:|..:.||   |.:....|:.:    ||..            .|.::........::..|.|.
Zfish  2713 SPLFRGQALWDAHTHVVLPPAALVPQRNVFSAPSPAGPVNLLANQTLEATAARRSLSLQEAPVSI 2777

  Fly   365 VISITIPGLNDTKLPGKL-----------------PFFLRNAKANETQFEGG------------- 399
            ||.:....|. ..||.|.                 |....:...|:|..||.
Zfish  2778 VIILIYRSLG-AALPPKYHTDRRGVRLPRHPVLNSPVVSISVYNNQTFVEGFLESPVLLEFRLLE 2841

  Fly   400 --------CGYWNYETWLSDGISTSGGGS---------LEASSHPVILCHADHLTQFTFLLGVS- 446
                    |..||:.:      ..||||.         ...:||  :.|....|..|..|:..|
Zfish  2842 TSNRSKPLCVQWNHSS------IVSGGGCWTVRDCSVLYRNTSH--VRCQCHRLGTFGVLMDSSQ 2898

  Fly   447 --KMQAGLDTNEDDHSLDVITNVGLTLSLLGLLMIFITAAVFKSFRTLAST--KILLNLCAALGL 507
              :::..|:|      |.::|...|::|:..||   :|..|....|.|.|.  .|..|:.||..|
Zfish  2899 REQLEGDLET------LAIVTYSSLSVSMAALL---LTVLVLSCLRGLKSNTRSIHSNMAAATLL 2954

  Fly   508 QLLFFLILSQSHLLEQLEQSESE-RCTLVGAVMQYLLLVVFSWMFIIGFLQYQRYVRVIGVNH-- 569
            ..|.:|:        .:.|:|.: .||:|..::.|..:..|:|:|:.....|:.......:|:
Zfish  2955 SHLTYLL--------GINQTEQQFLCTVVAILLHYFFMSAFAWLFVEALHIYRMQTEARNINYGA 3011

  Fly   570 PRHYILMSAVAAWTLPLIPTLLVVFLEPGSYRPNNSSMDYPILCYPSGYG-LSLGVILPIGLITV 633
            .|.|..:    .|.:|.|.|.|.|.|:|..|       ..|..|:.|.|. |......|:.::.:
Zfish  3012 MRFYYAI----GWGVPAIITGLAVGLDPEGY-------GNPDFCWISMYDKLMWSFAGPVSVVIL 3065

  Fly   634 ANA---ILVGYISWSVYTALFKRDLIFKQLGLFVLLFFLLGITWIFGLCTYFDFGRIFAYLFCLT 695
            .|.   ::|..::.:......|:..:...:.....|..|....|:|||....:....|.|||.:.
Zfish  3066 MNGGMFLMVLRMTCNPTQKEIKKLPVISTIRSAFFLLLLSTCVWLFGLMAVNNSVLAFHYLFIIL 3130

  Fly   696 ATLQGFVLFLYFIVFNKENQRAWLGLCCNSSKKRNQQTIQMP---------TDSILQ--GLSHSS 749
            ..:||..:.|.|.|.|.|.|.|| .|.|...|...::..:.|         :.|:|:  || |..
Zfish  3131 CCIQGLAVLLVFTVLNSEVQEAW-KLACLGKKSPGEEPPRPPQITGQNPYNSASLLEQSGL-HRI 3193

  Fly   750 TNSTS 754
            |..||
Zfish  3194 TLGTS 3198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	55/230 (24%)
celsr3	XP_009302289.1	Cadherin_repeat	715..814	CDD:206637
		Cadherin_repeat	822..924	CDD:206637
		Cadherin_repeat	933..1030	CDD:206637
		Cadherin_repeat	1038..1135	CDD:206637
		Cadherin_repeat	1143..1237	CDD:206637
		Cadherin_repeat	1245..1340	CDD:206637
		Cadherin_repeat	1349..1446	CDD:206637
		Cadherin_repeat	1455..1548	CDD:206637
		Cadherin_repeat	1568..1649	CDD:206637
		EGF_CA	1811..1846	CDD:238011
		EGF_CA	<1857..1887	CDD:238011
		LamG	1891..2074	CDD:238058
		EGF	2100..2130	CDD:278437
		LamG	2138..2293	CDD:238058
		EGF_CA	2319..2352	CDD:238011
		EGF_Lam	2448..2493	CDD:214543	9/44 (20%)
		HormR	2497..2558	CDD:214468	16/69 (23%)
		GAIN	2577..2818	CDD:293098	42/265 (16%)
		GPS	2846..2897	CDD:197639	13/58 (22%)
		7tm_4	2906..3138	CDD:304433	63/259 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910