DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15556 and adgra3

DIOPT Version :9

Sequence 1:	NP_001247379.1	Gene:	CG15556 / 43681	FlyBaseID:	FBgn0039821	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001289153.1	Gene:	adgra3 / 100003592	ZFINID:	ZDB-GENE-131003-2	Length:	1346	Species:	Danio rerio

Alignment Length:	819	Identity:	161/819 - (19%)
Similarity:	282/819 - (34%)	Gaps:	203/819 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 DFELEYETDEGKEKRINRVEKTRVGQKANLRDLCLNERG--------------IPIR-------- 114
            ::|....|..|...|...:.......|..|.|...|.:|              :|.:
Zfish   308 NWECRVRTSRGNNTRTVHIVVLESSAKYCLPDRVSNNKGEYRWPRTLAGITAYLPCKRQVTGAGI 372

  Fly   115 ------------RRCQIRNGNRVWQSLDHVTCRSAPELSSSINLLAVKSPPDMISQLSNLLTQTQ 167
                        |||. |.|.  |...|:..|....:::..:.::     ..|...|:|::...|
Zfish   373 YSGSSAEDRRAWRRCD-RGGQ--WAEDDYSRCEYMKDVTRVLYII-----NQMPLNLTNVVQTAQ 429

  Fly   168 EKLA----------AADVFSISEIFDSLVKKPERNAAVVGDLM-KICQKVMSTDNETL-RVSADA 220
            :.||          ..||..::|:.:.:.|..|:... :||:| .|...::..|...| ....:|
Zfish   430 QLLAYTAEAPNFSDKVDVIFVAEMIEKIGKFAEKYKE-LGDVMVDISSNLLLADERVLWMAQREA 493

  Fly   221 NATNALLSNFEDYLDELSPTILKLNTTIFANSTEFTFHPLFDMGVIVLKTSELR----VFF--VD 279
            .|.:.::.:.:..      .:|:::....|.||.   .|...:....:|.|...    ..|  :.
Zfish   494 RACSRMVESLQRI------ALLRVSNGALAYSTN---SPNIALEAHAIKASSFNGMTCTLFQKLS 549

  Fly   280 PEVRNVSGIVNFSGGNMSHFEMLHLSDN---EEDIRAMKN--LESAVFIPEKLWTQLKRKG-ASY 338
            || |.|..    ..|.:|....|....|   .....|:||  :|:::.:|..|::.|...| |..
Zfish   550 PE-RTVMA----HHGEISPERQLSFKCNVTSNLSALALKNTIVEASLQLPPTLFSSLGSSGQAEE 609

  Fly   339 LVFKV----YTRDSLFVET------EEEIKRRPTSNVISIT-IPG--LNDTKLPGKLPF--FLRN 388
            .|:|:    :....||..|      .:..|||.....:.|| |.|  |.|...|..:..  ||:.
Zfish   610 AVYKLHLLAFRNGKLFPPTGNSSILSDGSKRRSVVTPVMITKIEGFPLRDLLSPVNVTLRRFLQG 674

  Fly   389 AKANETQFEGGCGYWNYET------WLSDGISTSGGGSLEASSHPVILCHADHLTQFTFLLGVSK 447
            :.|..       .:||:..      |.|||.....    :..:...:.||:  |..:..|:.:::
Zfish   675 SDAVP-------AFWNFSLQGGQGGWQSDGCRILH----QDDNFTTVSCHS--LNSYAVLMDLNR 726

  Fly   448 MQAGLDTNEDDHSLDVITNVGLTLSLLGLLMIFITAAVFKSFRTLASTK---ILLNLCAALGLQL 509
            ....:......|.:...|.:.|.|.||.:::.:|..  .||.|  .|.|   :|:|||..:.|..
Zfish   727 TGYNVFIFRPLHPVIYSTALVLVLCLLSVIVSYIYH--HKSVR--ISKKCWHMLVNLCLHILLTC 787

  Fly   510 LFFL-ILSQSHLLEQLEQSESERCTLVGAVMQYLLLVVFSWMFIIGFLQYQRYVRVI----GVNH 569
            ..|: .::|::        .:..|..:|.|:.|..|....|..:.....|::..|..    .::.
Zfish   788 AVFVGGINQTY--------NASVCQAMGIVLHYSTLATALWSGVTARNIYKQVTRKAKRYEELDE 844

  Fly   570 P--------RHYILMSAVAAWTLPLIPTLLVVFLEPGSYRPNNSSMDYPILCY----PS---GYG 619
            |        |.|::...        ||.::.......:.:...|.::.| .|:    ||   .||
Zfish   845 PPPPPRPMLRFYLIGGG--------IPIIVCGITAAANIKNYGSQVNAP-YCWMAWEPSLGAFYG 900

  Fly   620 LS-----------LGVILPIG-------------------LITVANAILVGYISWS------VYT 648
            .:           |.:::.:.                   .:|.|..|...::..|      ..:
Zfish   901 PAAFIVFVDCMYFLSILIQLRRHPERRFELKEQSEEQQHLSVTEATEITPVHLESSPTAQPVPMS 965

  Fly   649 ALFKRDLIFKQLGLFVLLFFLLGITWIFG---LCTYFDFGRIFAYLFCLTATLQGFVLFLYFIVF 710
            ||........||........|....|:||   :........:||.||...|...|..|..:..|.
Zfish   966 ALENEHTFVSQLMGVAGSLTLYAALWVFGALAISQEHPADLVFACLFGALALGLGAFLVAHHCVN 1030

  Fly   711 NKENQRAWLGLCCNSSKKRNQQTIQMPTDSILQGLSHSS 749
            .::.:|.|...||   ..|....:|:  ||:|..::.||
Zfish  1031 RQDMRRHWSQACC---LIRRNYAVQV--DSLLLPIAGSS 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15556	NP_001247379.1	7tm_4	481..703	CDD:304433	52/283 (18%)
adgra3	NP_001289153.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..45
		LRR 1. /evidence=ECO:0000255	66..90
		leucine-rich repeat	70..93	CDD:275378
		LRR_RI	<73..162	CDD:238064
		LRR 2. /evidence=ECO:0000255	91..114
		LRR_8	92..152	CDD:290566
		leucine-rich repeat	94..117	CDD:275378
		LRR 3. /evidence=ECO:0000255	116..138
		leucine-rich repeat	118..141	CDD:275378
		LRR 4. /evidence=ECO:0000255	139..162
		leucine-rich repeat	142..165	CDD:275378
		LRRCT	176..223	CDD:214507
		IG_like	236..328	CDD:214653	4/19 (21%)
		Ig	241..324	CDD:299845	4/15 (27%)
		HRM	<350..403	CDD:280888	9/55 (16%)
		GAIN	424..648	CDD:293098	49/238 (21%)
		LRR 5. /evidence=ECO:0000255	503..529		5/34 (15%)
		LRR 6. /evidence=ECO:0000255	574..600		6/25 (24%)
		LRR 7. /evidence=ECO:0000255	611..632		5/20 (25%)
		GPS	680..721	CDD:280071	9/46 (20%)
		7tm_4	774..>923	CDD:304433	28/165 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1157..1188
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1202..1284
		PDZ-binding. /evidence=ECO:0000255	1344..1346
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910