DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and Adgrl2

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	XP_036019331.1	Gene:	Adgrl2 / 99633	MGIID:	2139714	Length:	1494	Species:	Mus musculus

Alignment Length:	834	Identity:	181/834 - (21%)
Similarity:	287/834 - (34%)	Gaps:	232/834 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 TSMFCEPEEFQH--DYITRNHDQTPHQNKWKR-ARIGERATLHDVCLLRNGM-----PVTRECRV 115
            |::|..||.|..  |:......||......:| ...|.|.|...:|:...|.     |....|
Mouse   464 TNIFPLPERFCEALDWKGIKWPQTQRGMMVERPCPKGTRGTASYLCMASTGTWNPKGPDLSNC-- 526

  Fly   116 KDNRANWESTEHW-----------DPVVCL-----RRFREHTISGDLNSLHDDVLEGRRRTNDTQ 164
                     |.||           :....|     :..:.|..:||::|             ..:
Mouse   527 ---------TSHWVNQLAQKIRSGENAASLANELAKHTKGHVFAGDVSS-------------SVR 569

  Fly   165 GRREMTGIMRNMFRQRGGNLLPADVHMTGQMFGALMQQDKDA----TVSVDLVSVCKEIMSCDS- 224
            ...::..|:....::    |.|::....|:.:..|.:::|..    ...||.|.......:.:|
Mouse   570 LMEQLVDILDAQLQE----LKPSEKDSAGRSYNKLQKREKTCRAYLKAIVDTVDNLLRAEALESW 630

  Fly   225 KVLRLSAQLNATNSLLSQFESYMDALPEQLVPKDRCGKVVAKPTS----DEAETATTG-VETYNF 284
            |.:..|.|.:....||...|.....|.:.|:...|    |:.||.    :.|..:|.| |:.:.|
Mouse   631 KHMNSSEQAHTATMLLDTLEEGAFVLADNLLEPTR----VSMPTENIVLEVAVLSTEGQVQDFKF 691

  Fly   285 SDIGVQALITGNISVFFANPECDRITGLAIFSAPGDQRKTSASGFWYRFIRFSEDLAKVKEESNL 349
             .:|::.|                          |...:.||:              .||:.|.
Mouse   692 -PLGLKGL--------------------------GSSIQLSAN--------------TVKQNSR- 714

  Fly   350 ETAAFLPENLWRQVKSRGATYLIFKVYAHDALFVET------------SLQRTRKPRSKVISISI 402
                            .|...|:|.:|.....|:.|            ....|....|.|||:||
Mouse   715 ----------------NGLAKLVFIIYRSLGQFLSTENATIKLGADLMGRNSTIAVNSPVISVSI 763

  Fly   403 PGLRSN-YLSLPLPFLLRNENLRNPDSKAFSIGSGCGYWNYET------WSTEG---VSTESSSD 457
            ....|. ||:.|:.|.|.:   .:||:   ...:.|.:|||..      |||:|   |.|..:.
Mouse   764 NKESSRVYLTDPVLFTLPH---IDPDN---YFNANCSFWNYSERTMMGYWSTQGCKLVDTNKTR- 821

  Fly   458 LLKDAIIECHTNHLTQFAFLVGGSYRANDLGEEILITPINEKVLDIISIVGCSLSLLGILGIFLT 522
                  ..|..:|||.||.|:.....|...|       ::..:|.:|:.||..:||:.:.....|
Mouse   822 ------TTCACSHLTNFAILMAHREIAYKDG-------VHHLLLTVITWVGIVVSLVCLAICIFT 873

  Fly   523 AALFKSWRSQASTKVLLHLCLAMCLQMMLFVFLNTDDVSEALVVNGNTVRCVALGAAMQYSILVL 587
            ...|:..:|..:|   :|..|.:.|.:..|:||...|.::      .|:.|......:.:..|..
Mouse   874 FCFFRGLQSDRNT---IHKNLCINLFIAEFIFLIGIDKTK------YTIACPVFAGLLHFFFLAA 929

  Fly   588 FSWMLIIAFLQFQRYVTVIGIE--RPPRYILKAAIVAWLLPLVPTLLVALIDPDSY-VPSAAQLS 649
            ||||.:.....:...|.|...|  |...|.    :..:|.|.....:.|.||..|| ...|..|.
Mouse   930 FSWMCLEGVQLYLMLVEVFESEYSRKKYYY----VAGYLFPATVVGVSAAIDYKSYGTVQACWLH 990

  Fly   650 TDTGICYPSGYGLIFGVVLPVTLITVCNLVIFVYVFYS-ISHSLS--------QSI--------- 696
            .|       .| .|:..:.|||.|.:.|::..|..... :.||.:        ::|
Mouse   991 VD-------NY-FIWSFIGPVTFIILLNIIFLVITLCKMVKHSNTLKPDSSRLENINNYRVCDGY 1047

  Fly   697 -------HKNEKKMVVKQIRLSIMLFFLLGLTWIFGIFAFMQAGVAFSYLFCITATMQGFVMFIY 754
                   :::.|..:...:..:..|..||||||.||:....:..|..:|||......||..:||:
Mouse  1048 YNTDLPGYEDNKPFIKSWVLGAFALLCLLGLTWSFGLLFVNEETVVMAYLFTAFNAFQGLFIFIF 1112

  Fly   755 FVLLDSTNR-------RLWV---GLICPTKMELDVQKRTTELQSMTTSSTNYNS 798
            ...|....|       |.|.   ||  ||:......|.:|     |.:|..|:|
Mouse  1113 HCALQKKVRKEYGKCFRHWYCCGGL--PTESPHSSVKAST-----TRTSARYSS 1159

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	14/46 (30%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	66/277 (24%)
Adgrl2	XP_036019331.1	Gal_Lectin	49..129	CDD:396628
		OLF	143..399	CDD:413369
		HormR	470..534	CDD:214468	17/74 (23%)
		GAIN	543..765	CDD:406802	53/300 (18%)
		GPS	789..841	CDD:197639	17/58 (29%)
		7tm_GPCRs	850..1130	CDD:421689	70/300 (23%)
		TM helix 1	851..876	CDD:410628	7/24 (29%)
		TM helix 2	885..907	CDD:410628	7/24 (29%)
		TM helix 3	916..943	CDD:410628	5/26 (19%)
		TM helix 4	955..975	CDD:410628	3/23 (13%)
		TM helix 5	992..1021	CDD:410628	9/36 (25%)
		TM helix 6	1037..1088	CDD:410628	11/50 (22%)
		TM helix 7	1092..1117	CDD:410628	8/24 (33%)
		Latrophilin	1129..1494	CDD:396778	12/38 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910