DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and ADGRE5

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_510966.1	Gene:	ADGRE5 / 976	HGNCID:	1711	Length:	835	Species:	Homo sapiens

Alignment Length:	683	Identity:	165/683 - (24%)
Similarity:	252/683 - (36%)	Gaps:	197/683 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 PADVH--MTGQMFGALMQQDKDATVS---VDLVSVCK---EIMSCDSKVLRLS---AQLNATNSL 239
            |..||  ...:.|..:....:|:..|   |.:.:|.|   |:|.....|..|:   ..|.|| .|
Human   267 PPGVHSQTLSRFFDKVQDLGRDSKTSSAEVTIQNVIKLVDELMEAPGDVEALAPPVRHLIAT-QL 330

  Fly   240 LSQFESYMDALPEQLVPKDRCGKVVAKPTSDEAETATTGVETYNFSDIGVQALITGNISVFFANP 304
            ||..|..|..|.:.| ||                    |..||                   .:|
Human   331 LSNLEDIMRILAKSL-PK--------------------GPFTY-------------------ISP 355

  Fly   305 ECDRITGLAIFSAPGDQRKTSASGFWYRFIRFSEDLAKVK---------EESNLETAAFLPENLW 360
            ....:|  .:....||:..|           ..:..|::|         |:.....|..|.....
Human   356 SNTELT--LMIQERGDKNVT-----------MGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNM 407

  Fly   361 RQVKSRGATYLIFKVYAHDALFVETSLQRTRKPR-SKVISISIPGLRSNYLSLPLPFLLRN---- 420
            ..:.:..:..|..|..|......|:|::..:..| |.|.||.:....:..|:.|:.|...:
Human   408 TTLLANASLNLHSKKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESS 472

  Fly   421 --ENLRNPDSKAFSIGSG----CGYWNYET-----WSTEGVSTESSSDLLKDAIIECHTNHLTQF 474
              |..|:|.:|....|..    |.:|..::     |:|||.....|    |:....|..:||:.|
Human   473 DGEAGRDPPAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGS----KNGSTTCQCSHLSSF 533

  Fly   475 AFLVGGSYRANDLGEEILITPINEKVLDIISIVGCSLSLLGILGIFLTAALFKSWRSQASTKVLL 539
            |.|: ..|...|.            .|.:|:.||.:|||..:|...||..|.:..:...:| :.|
Human   534 AILM-AHYDVEDW------------KLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTT-IHL 584

  Fly   540 HLCLAMCLQMMLFVFLNTDDVSEALVVN-GNTV--RCVALGAAMQYSILVLFSWM---------L 592
            |||:  ||.:...:||       |.:.| |..|  ||..:...:.|..|..|.||         |
Human   585 HLCI--CLFVGSTIFL-------AGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFL 640

  Fly   593 IIAFLQFQ----RYVTVIGIERPPRYILKAAIVAWLLPLVPTLLVALIDPDSYVPSAAQLSTDTG 653
            ::...|.|    |::.:||..                  ||.|:|.:        |||
Human   641 VVRVFQGQGLSTRWLCLIGYG------------------VPLLIVGV--------SAA------- 672

  Fly   654 ICYPSGY------------GLIFGVVLPVTLITVCNLVIFVYVFYSISHSLSQSIHKNEKKMVVK 706
             .|..||            |.::..:.|||.|.:||.||||...:.::...|: |:.:.||:  |
Human   673 -IYSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQKFSE-INPDMKKL--K 733

  Fly   707 QIR----LSIMLFFLLGLTWIFGIFAFMQAGVAFSYLFCITATMQGFVMFIYFVLLDSTNR---R 764
            :.|    .:|...||||.||:||:|.|....:..:|:|.|...:||..:::...||:...|   |
Human   734 KARALTITAIAQLFLLGCTWVFGLFIFDDRSLVLTYVFTILNCLQGAFLYLLHCLLNKKVREEYR 798

  Fly   765 LWVGLICPTKMELDVQKRTTELQSMTTSSTNYN 797
            .|..|:..       ..:.:|..| |||.|.:|
Human   799 KWACLVAG-------GSKYSEFTS-TTSGTGHN 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	11/42 (26%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	80/281 (28%)
ADGRE5	NP_510966.1	EGF_CA	64..99	CDD:284955
		EGF_CA	116..>148	CDD:214542
		EGF_CA	160..207	CDD:284955
		EGF_CA	209..243	CDD:284955
		GPS	493..536	CDD:280071	13/46 (28%)
		7tm_2	544..782	CDD:278432	81/296 (27%)
		ProP	608..>785	CDD:223553	57/213 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	814..835		6/11 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810