Protein Alignment Mayo and ADGRE3

DIOPT Version :10

• Sequence 1: NP_651842.3
• Gene: Mayo / 43678
• FlyBaseID: FBgn0039818
• Length: 802
• Species: Drosophila melanogaster
• Sequence 2: NP_115960.2
• Gene: ADGRE3 / 84658
• HGNCID: 23647
• Length: 652
• Species: Homo sapiens
• Alignment Length: 691
• Identity: 155/691 - (22%)
• Similarity: 266/691 - (38%)
• Gaps: 186/691 - (26%)

  Fly   133 CLRRFREHTISGDLNSLHDDVLEGRRRTNDTQGRREMTGIMRNMFRQRGGNLLPADVHMTGQMFG 197
            |:..:|.|:.:...::.:::..:....:..|:||:|:..|:...           :..:|.|
Human    96 CVPGYRLHSGNEQFSNSNENTCQDTTSSKTTEGRKELQKIVDKF-----------ESLLTNQ--- 146

  Fly   198 ALMQQDKDATVSVDLVSVCKEIMSCDSKVLRLSAQLNATNSLLSQFESYMDALPEQLVPKDRCGK 262
            .|.:.:....:|....::.:::   :||||..:.:......|..|.:|.  |:..|.: .|.|
Human   147 TLWRTEGRQEISSTATTILRDV---ESKVLETALKDPEQKVLKIQNDSV--AIETQAI-TDNC-- 203

  Fly   263 VVAKPTSDEAETATTGVETYNFSDIGVQALITGNISVFFANPECDRITGLAIFSAPGDQRKTSAS 327
                  |:|.:|....|: .|..||....:|                        .||.:..||
Human   204 ------SEERKTFNLNVQ-MNSMDIRCSDII------------------------QGDTQGPSA- 236

  Fly   328 GFWYRFIRFSEDLAKVKEESNLETAAFLPENLWRQVKSRGATYLIFKVYAHDALFVETSLQRTRK 392
               ..||.:|       ...|:..|.|..|     :..:...||
Human   237 ---IAFISYS-------SLGNIINATFFEE-----MDKKDQVYL--------------------- 265

  Fly   393 PRSKVISISIPGLRSNYLSLPLPFLLRNENLRNPDSKAFSIGSGCGYWNY----ETWSTEG---V 450
             .|:|:|.:|...|:..||..:....::..:.....|.|     |.||..    ..||.:|   :
Human   266 -NSQVVSAAIGPKRNVSLSKSVTLTFQHVKMTPSTKKVF-----CVYWKSTGQGSQWSRDGCFLI 324

  Fly   451 STESSSDLLKDAIIECHTNHLTQFAFLVGGSYRANDLGEEILITPINEKVLDIISIVGCSLSLLG 515
            ....|..:       |:.:||:.||.|:.            |.:...:.||.:|:.||.|:|||.
Human   325 HVNKSHTM-------CNCSHLSSFAVLMA------------LTSQEEDPVLTVITYVGLSVSLLC 370

  Fly   516 ILGIFLTAALFKSWRSQASTKVLLHLCLAMCLQMMLFVFLNTDDVSEALVVNGNTVRCVALGAAM 580
            :|...||..|.|:.|   :|...|||.|::||.:...:||...|.:|..|:      |..:..|:
Human   371 LLLAALTFLLCKAIR---NTSTSLHLQLSLCLFLAHLLFLVGIDRTEPKVL------CSIIAGAL 426

  Fly   581 QYSILVLFSWMLI--IAFLQFQRYVTVIGIERPPRYILKAAIVAWLL-PL---VPTLLVALIDPD 639
            .|..|..|:|||:  :......|.:||:......|      ::.|:: |:   ||.:.||:
Human   427 HYLYLAAFTWMLLEGVHLFLTARNLTVVNYSSINR------LMKWIMFPVGYGVPAVTVAI---- 481

  Fly   640 SYVPSAAQLSTDTGICYPSGY------------GLIFGVVLPVTLITVCNLVIFVYVFYSISHSL 692
                |||.        :|..|            |.::..:.||..|...|||:|:.||:.:...|
Human   482 ----SAAS--------WPHLYGTADRCWLHLDQGFMWSFLGPVCAIFSANLVLFILVFWILKRKL 534

  Fly   693 SQ-----SIHKNEKKMVVKQIRLSIMLFFLLGLTWIFGIFAFMQAGVAFSYLFCITATMQGFVMF 752
            |.     |..:|.:.:..|    :....|:||.||..|:.....|....:|||.|..::|||.:|
Human   535 SSLNSEVSTIQNTRMLAFK----ATAQLFILGCTWCLGLLQVGPAAQVMAYLFTIINSLQGFFIF 595

  Fly   753 IYFVLLDSTNRRLWVGLICPTKMELDVQKRTTELQSMTTSS 793
            :.:.||....::.:      .|...::.|..:|.::.|.||
Human   596 LVYCLLSQQVQKQY------QKWFREIVKSKSESETYTLSS 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mayo	NP_651842.3	7tmB2_Adhesion	498..766	CDD:320168	82/290 (28%)
		TM helix 1	500..525	CDD:320168	12/24 (50%)
		TM helix 2	535..557	CDD:320168	9/21 (43%)
		TM helix 3	574..600	CDD:320168	7/27 (26%)
		TM helix 4	615..635	CDD:320168	5/23 (22%)
		TM helix 5	659..688	CDD:320168	11/40 (28%)
		TM helix 6	704..730	CDD:320168	7/25 (28%)
		TM helix 7	734..759	CDD:320168	9/24 (38%)
ADGRE3	NP_115960.2	EGF_CA	67..104	CDD:238011	2/7 (29%)
		GPS	304..344	CDD:460350	12/46 (26%)
		7tm_GPCRs	353..614	CDD:475119	83/301 (28%)
		TM helix 1	356..380	CDD:410628	11/23 (48%)
		TM helix 2	389..410	CDD:410628	8/20 (40%)
		TM helix 3	420..442	CDD:410628	7/21 (33%)
		TM helix 4	466..482	CDD:410628	5/23 (22%)
		TM helix 5	501..524	CDD:410628	7/22 (32%)
		TM helix 6	551..573	CDD:410628	7/25 (28%)
		TM helix 7	577..602	CDD:410628	9/24 (38%)