DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and adgrd2

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	XP_021334184.1	Gene:	adgrd2 / 571770	ZFINID:	ZDB-GENE-081104-190	Length:	1145	Species:	Danio rerio

Alignment Length:	768	Identity:	162/768 - (21%)
Similarity:	276/768 - (35%)	Gaps:	225/768 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 CTSMFCEPEEFQHDYITRNHDQTPHQNKWKRARIGERATLHDV--CLLRNGMPVTRECRVKDNRA 120
            ||..|        .:|.|  ..|.|..|.|..|...|:.....  .|::.||      ..:|..:
Zfish   442 CTHTF--------PFICR--ISTEHYLKMKELRESLRSNPSPFMQSLMQYGM------TAEDVLS 490

  Fly   121 NWESTEHWDPVVCLRRFREHTISGDLNSLHDDVLEGRRRTNDTQGRREMTGIMRNMFRQRG---- 181
            :....:.|..|..|....|..:..:...|.|               |:|..::..:.|...
Zfish   491 DAVDDQSWASVSRLLNVSEQVMLTEQKPLED---------------RDMVSLVHVLSRAADLPIT 540

  Fly   182 GNLLPADVHMTGQMF-----GALMQQDKDATVSVDLVSVCKEIMSCDSKVLRLSAQLNATNSLLS 241
            .|...||....||.|     ..|.|.|.:...|:.  .|.|..|:....|.|:...|   ||||:
Zfish   541 ANHSRADAETLGQSFITIADSLLSQDDHEKWQSIK--EVVKGPMAVIQTVERMGINL---NSLLT 600

  Fly   242 QFESYMDALPEQLVPKDRCGKVVAKPTSDEAETATTGVETYNFSDIGVQALIT--GNISVFF--- 301
            .                              :|.:..:.::|......|.|::  .::|.|.
Zfish   601 D------------------------------DTDSVQIHSHNIKLQVQQKLLSEDPHVSAFCGSD 635

  Fly   302 -ANPECDRITGLAIFSAP---------GDQRKTSASGFWYRFIR-FSEDLAKVKEESNLETAAFL 355
             .|.:|        .|.|         .|.||.:....|:..:: .||      :|.|:.....:
Zfish   636 GGNRDC--------ISVPAKNMKELRNNDFRKVTVLNTWFSSVKCLSE------KEENISLFPIV 686

  Fly   356 PENLWRQVKSRGATYLIFKVYAHDALFVETSLQRTRKPRSKVISISI-----PGLRSNYLSLPLP 415
            .:...|                    ||.|.|      .|.|||.::     |      :|:.:.
Zfish   687 TDGSQR--------------------FVGTVL------GSSVISSTVLADEQP------VSVAIH 719

  Fly   416 FLLRNENLRNPDSKAFSIGSGCGYWNYET------WSTEG---VSTESSSDLLKDAIIECHTNHL 471
            |.|:: .|:|...|...:   |.:|:::.      |||:|   :||:::|       ..|:.||.
Zfish   720 FTLQH-RLQNTSVKFIPV---CAFWDFDLMSDGGGWSTKGCVVISTQNNS-------TSCYCNHT 773

  Fly   472 TQFAFLVGGSYRANDLGEEILITPINEKVLDIISIVGCSLSLLGILGIFLTAALFKSWRSQASTK 536
            |.||.|: ..|       |:....:::..|.|:|::|.::||..::..|:   ||.:.....|.:
Zfish   774 TNFALLL-QIY-------EVQRDAVHDAGLQILSLIGSAVSLCALIFTFI---LFVAVGVPKSDR 827

  Fly   537 VLLHLCLAMCLQMMLFVFLNTDDVSEALVVNGNTVRCVALGAAMQYSILVLFSWMLIIAFLQFQR 601
            ..:|..|...|.:..|:.:.:|..:      |:...|..:.|.:....|..|.|||:...|.:.:
Zfish   828 TTVHKNLMAALIVAQFLLILSDWAA------GSQEACWLVTALLHLFFLSSFCWMLVEGLLLWSK 886

  Fly   602 YVTV-IGIERPPR--YILKAAIVAWLLPLVPTLLVALIDPDSYVPSAAQ---LSTDTGICYPSGY 660
            .|:| |..:|..:  |:|     .|.||:|...:..:...|.|  .|.|   |:..:.:
Zfish   887 VVSVNISEDRRMKMYYVL-----GWGLPVVIVAVTLVATLDQY--KAQQHCWLNLQSSV------ 938

  Fly   661 GLIFGVVLPVTLITVCN-LVIFVYVFYSISHSLSQSIHKNEKKMVVKQ--------------IRL 710
              |:....||..:...| :|:|..|..::|.:      :...||:...              .|.
Zfish   939 --IWAFAGPVLFVLAVNAVVLFRVVLVTVSSA------RRRAKMLTPSSDSKLHTLDLTWAATRP 995

  Fly   711 SIMLFFLLGLTWIFGIFAFMQAGVAFSYLFCITATMQGFVMFIYFVLLDSTNR 763
            .::|..:|||||:.|:...:...:|  |||......||..:|:.:.:.:|..|
Zfish   996 VLILLPVLGLTWLCGVLVHLSDVMA--YLFITLNAFQGLYIFLVYAVYNSEVR 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	13/46 (28%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	63/270 (23%)
adgrd2	XP_021334184.1	LamG	204..402	CDD:328935
		GPS	735..779	CDD:307782	15/53 (28%)
		7tmB2_GPR144	792..1054	CDD:320383	66/287 (23%)
		TM helix 1	794..819	CDD:320383	9/27 (33%)
		TM helix 2	828..850	CDD:320383	4/21 (19%)
		TM helix 3	859..886	CDD:320383	7/26 (27%)
		TM helix 4	898..918	CDD:320383	6/24 (25%)
		TM helix 5	935..964	CDD:320383	7/36 (19%)
		TM helix 6	988..1015	CDD:320383	8/26 (31%)
		TM helix 7	1017..1042	CDD:320383	7/26 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910